ARLN and SLCO3A1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		ARLN	SLCO3A1
Name		allregulin	solute carrier organic anion transporter family member 3A1
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane
	Molecular Function	Protein Binding	Protein Binding Organic Anion Transmembrane Transporter Activity Prostaglandin Transmembrane Transporter Activity Sodium-independent Organic Anion Transmembrane Transporter Activity
	Biological Process	None	Monoatomic Ion Transport Prostaglandin Transport Positive Regulation Of Canonical NF-kappaB Signal Transduction Sodium-independent Organic Anion Transport Positive Regulation Of MAPK Cascade Transmembrane Transport Transport Across Blood-brain Barrier
GWAS		No GWAS studies recorded	Acute lymphoblastic leukemia (childhood) ( 22076464 ) Adult body size ( 32376654 ) Dementia and core Alzheimer's disease neuropathologic changes ( 25188341 ) Diastolic blood pressure ( 30224653 ) DNA methylation (variation) ( 23725790 ) Estimated glomerular filtration rate reduction (30%) ( 30955190 ) Gastroesophageal reflux disease ( 27485664 ) Inattentive symptoms ( 18821565 ) Neuritic plaque ( 25188341 ) Obesity-related traits ( 23251661 ) Orofacial cleft x maternal periconceptional alcohol use interaction (1df) ( 33937227 ) Post bronchodilator FEV1/FVC ratio ( 26634245 ) Primary sclerosing cholangitis ( 27992413 ) Refractive error ( 32231278 ) Response to iloperidone treatment (QT prolongation) ( 18521091 ) Smoking initiation ( 24665060 )
Novel Interactors		None recorded	1 novel interactors: ACAN
Interacting Genes		73 interacting genes: ADGRG3 AQP2 AQP6 ARL13B ATP2A2 BCL2L13 BIK C5AR2 CALM1 CCRL2 CD79A CISD2 CLDN9 CREB3L1 CXCR2 CYBC1 EBP ELN ELOVL4 ERGIC3 FAM174A FAM209A FFAR2 GJA5 GJB4 GJB5 GLP1R GPR61 GPX8 HHATL HTR2C JAGN1 LAPTM5 LMNA LY6G6C MILR1 MMD MMGT1 MRM3 MS4A3 NCAPH2 PLEKHO1 PLN PTGES REEP4 RETREG3 RHBDL1 RHCG SCN3B SERINC2 SHISAL1 SLC10A6 SLC14A2 SLC19A3 SLC35E3 SLC35H1 SLC39A2 SLC41A3 SLC71A2 SLCO3A1 SMO SSMEM1 STX1A SYNPR TIMMDC1 TM4SF19 TMEM101 TMEM237 TMEM248 TMEM45A TMEM45B TMEM51 YIF1A	7 interacting genes: AQP6 ARLN GOLM1 NHERF1 NHERF2 NHERF4 TRARG1
Entrez ID		401152	28232
HPRD ID		14223	07502
Ensembl ID		ENSG00000164096	ENSG00000176463
Uniprot IDs		Q8WVX3	Q9UIG8
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Membrane Transmembrane Transport Protein Binding Plasma Membrane Calcium Ion-transporting ATPase Complex Endoplasmic Reticulum Membrane G Protein-coupled Receptor Activity Connexin Complex Regulation Of Heart Rate Gap Junction Channel Activity Carbon Dioxide Transmembrane Transporter Activity One-carbon Compound Transport Carbon Dioxide Transmembrane Transport Gap Junction Regulation Of Heart Contraction Regulation Of Cardiac Muscle Cell Action Potential Transporter Inhibitor Activity SA Node Cell Action Potential Transmembrane Transporter Binding Mitochondrion-endoplasmic Reticulum Membrane Tethering Regulation Of Cardiac Muscle Cell Membrane Potential Autophagosome Membrane Docking Regulation Of Cardiac Muscle Contraction Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization G Protein-coupled Receptor Signaling Pathway Renal Water Transport Regulation Of System Process Ammonium Channel Activity Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Ammonium Transmembrane Transport Regulation Of Blood Circulation Calcium-mediated Signaling Metal Ion Transport Regulation Of Striated Muscle Contraction	Type 3 Metabotropic Glutamate Receptor Binding Protein-membrane Adaptor Activity Type 2 Metabotropic Glutamate Receptor Binding Protein Localization To Plasma Membrane Protein Localization To Cell Periphery Protein Localization To Membrane Water Transport Localization Within Membrane Fluid Transport Endomembrane System Phosphatase Binding Nitrate Transmembrane Transporter Activity Renal Phosphate Ion Absorption Guanylate Cyclase Inhibitor Activity Apical Plasma Membrane Signaling Receptor Binding Apical Part Of Cell PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Beta-catenin Binding Renal System Process Carbon Dioxide Transmembrane Transporter Activity Cytoplasmic Vesicle Membrane Carbon Dioxide Transmembrane Transport Cellular Localization Molecular Adaptor Activity Maintenance Of Epithelial Cell Apical/basal Polarity Bile Acid Secretion Microvillus Assembly Channel Activator Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity Beta-2 Adrenergic Receptor Binding Chloride Channel Regulator Activity Gamma-aminobutyric Acid Import Growth Factor Receptor Binding Negative Regulation Of CGMP-mediated Signaling Glucose Import In Response To Insulin Stimulus Monoatomic Anion Channel Activity Renal Water Transport Microvillus Organization Establishment Of Golgi Localization Phospholipase C-activating Dopamine Receptor Signaling Pathway Ammonium Channel Activity Intracellular Phosphate Ion Homeostasis Extracellular Matrix Structural Constituent Conferring Compression Resistance Perineuronal Net Ammonium Transmembrane Transport Water Channel Activity