MUC16 and MSLN

Number of citations of the paper that reports this interaction (PubMedID 14676194)
0

Data Source:
HPRD (in vitro)

		MUC16	MSLN
Description		mucin 16, cell surface associated	mesothelin
Image
GO Annotations	Cellular Component	Extracellular Region Golgi Lumen Plasma Membrane External Side Of Plasma Membrane Membrane Vesicle Extracellular Exosome	Extracellular Region Endoplasmic Reticulum Lumen Golgi Apparatus Plasma Membrane Cell Surface Membrane Side Of Membrane
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Cell Adhesion	Cell Adhesion Cell-matrix Adhesion
Pathways		Defective GALNT3 causes HFTC Defective C1GALT1C1 causes TNPS Defective GALNT12 causes CRCS1 Dectin-2 family O-linked glycosylation of mucins Termination of O-glycan biosynthesis	Post-translational modification: synthesis of GPI-anchored proteins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Dimethyl sulfoxide Oregovomab	Amatuximab
Diseases
GWAS		Asthma ( 30929738 32296059) Hepcidin/transferrin saturation ratio ( 27846281) Serum cancer antigen 125 (CA 125) levels ( 31666285) Tourette syndrome ( 30818990)	Body mass index ( 26426971) Serum cancer antigen 125 (CA 125) levels ( 31666285)
Interacting Genes		3 interacting genes: LGALS1 MSLN UBC	3 interacting genes: APPBP2 CPLANE2 MUC16
Entrez ID		94025	10232
HPRD ID		07548	03030
Ensembl ID		ENSG00000181143	ENSG00000102854
Uniprot IDs		A0AAG2UXK0 B3KY81 Q8WXI7	Q13421
PDB IDs		7SA9 8GKL 8VM1 8VRS	4F3F 7U8C 7U9J 7UED 8CX3 8CXC 8CYH 8CZ8 8FSL 8VM1
Enriched GO Terms of Interacting Partners?		Lactose Binding Positive Regulation Of Dendritic Cell Differentiation Galectin Complex Negative Regulation Of T-helper 17 Cell Lineage Commitment Plasma Cell Differentiation Nuclear Migration Along Microfilament Microtubule-based Transport Nuclear Migration Along Microtubule Nuclear Matrix Organization Nucleokinesis Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Cytoskeleton-nuclear Membrane Anchor Activity Nuclear Matrix Anchoring At Nuclear Membrane Determination Of Heart Left/right Asymmetry Outer Dynein Arm Docking Complex
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