MUC16 and MSLN

Number of citations of the paper that reports this interaction (PMID 14676194)
84

Data Source:
HPRD (in vitro)

		MUC16	MSLN
Gene Name		mucin 16, cell surface associated	mesothelin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Golgi Lumen Plasma Membrane Integral Component Of Membrane Extrinsic Component Of Membrane Vesicle Extracellular Vesicular Exosome	Extracellular Space Golgi Apparatus Plasma Membrane Cell Surface Membrane Anchored Component Of Membrane
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Protein O-linked Glycosylation Cell Adhesion O-glycan Processing Post-translational Protein Modification Cellular Protein Metabolic Process	Cell Adhesion Pancreas Development
Pathways		Post-translational protein modification Termination of O-glycan biosynthesis O-linked glycosylation of mucins O-linked glycosylation
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: LGALS1 MSLN UBC	2 interactors: MUC16 RSG1
Entrez ID		94025	10232
HPRD ID		07548	03030
Ensembl ID		ENSG00000181143	ENSG00000102854
Uniprot IDs		B3KY81 B5ME49 Q8WXI7	Q13421
PDB IDs			4F3F
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Erythrocyte Aggregation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of I-kappaB Kinase/NF-kappaB Signaling Plasma Cell Differentiation Viral Protein Processing Mature B Cell Differentiation Involved In Immune Response Mature B Cell Differentiation Notch Receptor Processing Virion Assembly Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Glycogen Biosynthetic Process Intracellular Transport Of Virus Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Immune System Process Apoptotic Process Cellular Polysaccharide Biosynthetic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Programmed Cell Death Polysaccharide Biosynthetic Process Negative Regulation Of Type I Interferon Production Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Myoblast Differentiation Cell Death Death Negative Regulation Of ERBB Signaling Pathway B Cell Activation Involved In Immune Response Negative Regulation Of Cell-substrate Adhesion Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of DNA-templated Transcription In Response To Stress DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Toll-like Receptor 2 Signaling Pathway Signal Transduction Involved In DNA Damage Checkpoint Toll-like Receptor 9 Signaling Pathway Signal Transduction Involved In Cell Cycle Checkpoint Cellular Response To Glucose Stimulus Glycogen Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway
Tagcloud ?		altering arhi atlas belong brca1 ca125 clarified cnvs consequences copy diras3 dysregulated emphasis he4 imprinted messenger micrornas mirna mirnas mirs ovarian profiling projects remarkable rnas summarizes tcga variations wfdc2	aml arrays bfm blinded ccl23 cytological cytology day15 day28 dismal gaged2 lab monitoring mrd multicenter normalized prame prognostic prospectively relapse rfs se spag6 st18 standardized stratified survived taqman wt1
Tagcloud (Difference) ?		altering arhi atlas belong brca1 ca125 clarified cnvs consequences copy diras3 dysregulated emphasis he4 imprinted messenger micrornas mirna mirnas mirs ovarian profiling projects remarkable rnas summarizes tcga variations wfdc2	aml arrays bfm blinded ccl23 cytological cytology day15 day28 dismal gaged2 lab monitoring mrd multicenter normalized prame prognostic prospectively relapse rfs se spag6 st18 standardized stratified survived taqman wt1
Tagcloud (Intersection) ?