SLC35E1 and MCOLN1

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		SLC35E1	MCOLN1
Name		solute carrier family 35 member E1	mucolipin TRP cation channel 1
Structure		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Membrane	Phagocytic Cup Nucleoplasm Lysosome Lysosomal Membrane Endosome Late Endosome Golgi Apparatus Plasma Membrane Endosome Membrane Membrane Cytoplasmic Vesicle Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Late Endosome Membrane Cell Projection Receptor Complex
	Molecular Function	Protein Binding Antiporter Activity	Monoatomic Anion Channel Activity Monoatomic Cation Channel Activity Calcium Channel Activity Potassium Channel Activity Sodium Channel Activity Iron Ion Transmembrane Transporter Activity Protein Binding Lipid Binding Identical Protein Binding NAADP-sensitive Calcium-release Channel Activity Intracellularly Phosphatidylinositol-3,5-bisphosphate-gated Monatomic Cation Channel Activity Ligand-gated Calcium Channel Activity
	Biological Process	Transmembrane Transport	Adaptive Immune Response Immune System Process Monoatomic Ion Transport Monoatomic Cation Transport Calcium Ion Transport Lysosome Organization Calcium-mediated Signaling Transferrin Transport Monoatomic Ion Transmembrane Transport Iron Ion Transmembrane Transport Sodium Ion Transmembrane Transport Negative Regulation Of Innate Immune Response Release Of Sequestered Calcium Ion Into Cytosol Protein Homotetramerization Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Cellular Response To PH Potassium Ion Transmembrane Transport Phagosome Maturation Autophagosome Maturation Monoatomic Cation Transmembrane Transport Monoatomic Anion Transmembrane Transport Antibacterial Innate Immune Response Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Localization To Nucleus Calcium Ion Export Positive Regulation Of Lysosome Organization
Pathways		None	TRP channels Transferrin endocytosis and recycling
Diseases		None	Mucolipidosis IV
GWAS		No GWAS studies recorded	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Mean platelet volume ( 32888494 ) Opioid overdose severity score ( 31362332 )
Novel Interactors		1 novel interactors: COLGALT1	None recorded
Interacting Genes		6 interacting genes: ABCF3 FTHL17 FXYD6 LAMA3 MCOLN1 MPP1	5 interacting genes: APPBP2 GPR35 SEC22A SLC35E1 TRIM27
Entrez ID		79939	57192
HPRD ID		15373	05582
Ensembl ID		ENSG00000127526	ENSG00000090674
Uniprot IDs		Q96K37	Q9GZU1
PDB IDs		Not available	5TJA 5TJB 5TJC 5WJ5 5WJ9 6E7P 6E7Y 6E7Z 7MGL
GO Terms Enriched among Interactors		Laminin-5 Complex Hemidesmosome Assembly Hemidesmosome Laminin-3 Complex Monoatomic Cation Transport Positive Regulation Of Sodium Ion Export Across Plasma Membrane Potassium Ion Transport Metal Ion Transport Sodium Ion Transport Ion Channel Regulator Activity Iron Ion Transport Ferric Iron Binding Positive Regulation Of Lysosome Organization Monoatomic Anion Channel Activity Intracellularly Phosphatidylinositol-3,5-bisphosphate-gated Monatomic Cation Channel Activity Calcium Ion Export Ligand-gated Calcium Channel Activity NAADP-sensitive Calcium-release Channel Activity Iron Ion Transmembrane Transporter Activity Procollagen Galactosyltransferase Activity Positive Regulation Of Collagen Fibril Organization GMP Kinase Activity Regulation Of Collagen Fibril Organization GDP Metabolic Process Monoatomic Ion Transport Transferrin Transport Phagosome Maturation	None