SMIM1 and BCL2L13

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SMIM1	BCL2L13
Description		small integral membrane protein 1 (Vel blood group)	BCL2 like 13
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane	Nucleus Mitochondrion Membrane Mitochondrial Membrane
	Molecular Function	Protein Binding Protein Homodimerization Activity	Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process
	Biological Process		Mitophagy Oxidative Phosphorylation Apoptotic Process Mitochondrion Organization Regulation Of Apoptotic Process Fat Cell Differentiation Canonical Glycolysis
Pathways
Drugs
Diseases
GWAS		Glycated hemoglobin levels ( 34059833) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 27863252 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494 27863252) Red cell distribution width ( 28957414 27863252 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)	Baseline cortisol levels in response to low dose short synacthen test in corticosteroid treated asthma ( 29551627) Eosinophil count ( 32888494) Granulocyte count ( 27863252) Hemoglobin levels ( 32327693) Interleukin-10 levels ( 22205395) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Neutrophil percentage of white cells ( 32888494) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494)
Interacting Genes		58 interacting genes: ANKS6 AQP6 ASZ1 BCL2L13 BIK CD74 CISD2 COMT CPLX4 CREB3L1 CYB561 EBP ELOVL4 ERGIC3 FAM174A FAM209A FAM210B FCER1G FFAR2 FNDC9 GJA8 GJB5 HACD2 HSD17B13 ICAM3 JAGN1 KIR2DL3 LHFPL5 LRP10 LRRC4C MFF MFSD6 MUC1 NAALAD2 NDUFAF2 PVR REEP4 RELL2 RETREG3 SAR1A SCN3B SDC3 SIGLEC7 SLC10A6 SLC18A1 SLC26A11 STING1 STX1A TM4SF19 TMEM154 TMEM31 TMEM45B TMEM51 TMEM52B TMEM86B TMPRSS2 TMX2 ZDHHC15	84 interacting genes: ACP5 ADIPOQ AGTRAP AIG1 APOD APP AQP1 ARL6IP1 ARLN BAZ2B BCL9 BET1 CAMLG CD53 CDC42 CDK5R1 CERS6 CLDN19 CRB3 DEFB127 ERG28 ERMP1 ETNK2 FAM210B FUS FXYD3 FZD7 GABARAPL2 GALNT2 GAST GTF2F1 HMOX2 HNRNPK IDI1 JAGN1 JPH4 LAT LAYN LPAR3 MAL MGMT MTNR1B NDRG4 NETO2 NINJ2 NR2C2AP NRBP1 PCBP1 PLLP PLN PLP1 PLPP4 PPT2 RPN2 SH3RF3 SLC30A8 SLC35A1 SLC35G5 SMARCD3 SMIM1 SPOCK1 SQLE SRSF3 STX12 STX8 TM6SF2 TMEM128 TMEM14C TMEM242 TMEM254 TMEM51 TMEM72 TMEM86A TMEM86B TMEM97 TMUB2 TNF TNMD TRARG1 TUBB UBC UPK1B VAMP3 VAMP4
Entrez ID		388588	23786
HPRD ID			09822
Ensembl ID		ENSG00000235169	ENSG00000099968
Uniprot IDs		B2RUZ4 M4WDD3	A0A087WTL4 A0A087WW80 A0A087WX97 A0A0A0MR90 A8K5Y4 B2RB43 B7Z238 B7Z737 E9PDD6 F2Z2C3 F6VJB4 Q9BXK5
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Endoplasmic Reticulum Membrane Endoplasmic Reticulum Negative Regulation Of Peptide Secretion Monoamine Transport	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Localization Within Membrane SNARE Complex Cellular Localization Response To Type II Interferon Structural Constituent Of Myelin Sheath Protein Binding Regulation Of Transport Alkenylglycerophosphocholine Hydrolase Activity Cellular Response To Type II Interferon SNAP Receptor Activity Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Organelle Fusion Regulation Of Cellular Localization Phagocytic Vesicle Membrane Raft Regulation Of Chemokine Production Protein Localization To Membrane Protein Localization To Cell Periphery Vesicle Fusion Vesicle Organization Organelle Membrane Fusion Negative Regulation Of Blood Circulation Vesicle Docking Regulation Of Establishment Of Protein Localization Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Protein Transport Response To Cytokine Protein Localization To Plasma Membrane Response To Peptide Positive Regulation Of Chemokine Production G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Membrane Raft Distribution Establishment Of Protein Localization To Membrane Recycling Endosome Organelle Localization By Membrane Tethering Membrane Raft Localization
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