SMIM1 and MUC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SMIM1	MUC1
Description		small integral membrane protein 1 (Vel blood group)	mucin 1, cell surface associated
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane	Chromatin Extracellular Region Extracellular Space Nucleus Cytoplasm Golgi Lumen Plasma Membrane Membrane Apical Plasma Membrane Vesicle Extracellular Exosome
	Molecular Function	Protein Binding Protein Homodimerization Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding P53 Binding Transcription Coregulator Activity Protein Binding
	Biological Process		Negative Regulation Of Transcription By Competitive Promoter Binding DNA Damage Response, Signal Transduction By P53 Class Mediator Mitotic G1 DNA Damage Checkpoint Signaling Negative Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Pathways			Defective GALNT3 causes HFTC Defective C1GALT1C1 causes TNPS Defective GALNT12 causes CRCS1 Dectin-2 family Interleukin-4 and Interleukin-13 signaling O-linked glycosylation of mucins Termination of O-glycan biosynthesis Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Alveolar Cells
Drugs			TG4010
Diseases
GWAS		Glycated hemoglobin levels ( 34059833) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 27863252 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494 27863252) Red cell distribution width ( 28957414 27863252 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 21102463 28067908) Estimated glomerular filtration rate ( 31015462) Gastric adenocarcinoma (histologically verified) ( 26098866) Gastric cancer ( 26098866 26129866 31383772) Gout ( 31578528) Inflammatory bowel disease ( 28067908) Magnesium levels ( 26058915 25886283 20700443) Non-cardia gastric cancer ( 26701879) Serum magnesium levels ( 29093028) Serum uric acid levels ( 30993211 29403010) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urinary albumin-to-creatinine ratio ( 26631737) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737)
Interacting Genes		58 interacting genes: ANKS6 AQP6 ASZ1 BCL2L13 BIK CD74 CISD2 COMT CPLX4 CREB3L1 CYB561 EBP ELOVL4 ERGIC3 FAM174A FAM209A FAM210B FCER1G FFAR2 FNDC9 GJA8 GJB5 HACD2 HSD17B13 ICAM3 JAGN1 KIR2DL3 LHFPL5 LRP10 LRRC4C MFF MFSD6 MUC1 NAALAD2 NDUFAF2 PVR REEP4 RELL2 RETREG3 SAR1A SCN3B SDC3 SIGLEC7 SLC10A6 SLC18A1 SLC26A11 STING1 STX1A TM4SF19 TMEM154 TMEM31 TMEM45B TMEM51 TMEM52B TMEM86B TMPRSS2 TMX2 ZDHHC15	143 interacting genes: ABL1 ADAM33 ADGRB3 ADIPOQ ANKRD46 APC APOA2 APP AQP1 AQP2 AQP3 ARV1 ATM BCL2L2 BMI1 BRICD5 BTN2A2 C14orf180 C1GALT1 C2 C2CD2L C3orf52 CACNG1 CCDC167 CD47 CD53 CD68 CLDN19 CLDN6 CLDND2 CMTM7 COL8A2 CSGALNACT2 CTNNB1 CTNND1 CTSA CXCL16 CXCL9 CYB5B CYP4F2 EDDM3B EGFR EMC6 EMP3 ENTPD3 ERBB2 ERBB3 ERBB4 ERG28 ESR1 EZH2 GALNT1 GALNT10 GALNT12 GALNT15 GALNT2 GALNT4 GAST GDNF GOLT1B GPR108 GRB2 GSK3B H2AX HHATL HSP90AA1 HSPA4 ICMT INSIG2 ITGAM JUP LCK LPAR3 LYN MAL2 MALL MARCHF2 MIP MYADM NDUFA3 NEU1 NINJ1 NINJ2 NKG7 NUP62 OR10AG1 OSGEP PAQR6 PLN PLP1 PLP2 PLPP6 PNLIPRP1 PPARG PPIF PRKCD RFT1 RHD RTP2 SCAMP5 SEC22B SELENOK SERP2 SFTPC SIGLEC1 SLC22A1 SLC30A8 SLC35B4 SLC35E4 SLC38A7 SLC61A1 SMCO4 SMIM1 SOS1 SRC TECR THBD TM6SF2 TMEM11 TMEM120B TMEM121 TMEM128 TMEM147 TMEM14A TMEM14C TMEM187 TMEM218 TMEM229B TMEM243 TMEM86A TMEM86B TMEM97 TMEM98 TNFRSF10B TP53 TRAM1L1 TWIST1 UNC50 VAMP5 VKORC1 YIPF6 ZAP70 ZDHHC21
Entrez ID		388588	4582
HPRD ID			01152
Ensembl ID		ENSG00000235169	ENSG00000185499
Uniprot IDs		B2RUZ4 M4WDD3	A0A087X0L2 A0A0A0MRB3 A0A0C4DGW3 A0A384NPK6 A5YRU5 A5YRU7 A5YRV0 A5YRV2 A6ZID6 A6ZID7 A6ZIE4 A6ZIE6 B6ECB3 P15941 Q7Z538 Q7Z551
PDB IDs			1SM3 2ACM 2FO4 5T6P 5T78 6FZQ 6FZR 6KX1 6TGG 7Q4I 7V4W 7V64 7V7K 7V8Q 7VAC 7VAZ 8AXH 8P6I
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Endoplasmic Reticulum Membrane Endoplasmic Reticulum Negative Regulation Of Peptide Secretion Monoamine Transport	Membrane Polypeptide N-acetylgalactosaminyltransferase Activity Epidermal Growth Factor Receptor Signaling Pathway Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane ERBB Signaling Pathway Ephrin Receptor Binding Protein Tyrosine Kinase Activity Regulation Of Transport Positive Regulation Of Protein Localization Protein O-linked Glycosylation Via N-acetyl-galactosamine Leukocyte Activation Cellular Response To Oxygen-containing Compound Golgi Membrane Positive Regulation Of Transport ERBB2 Signaling Pathway Glial Cell Development Non-membrane Spanning Protein Tyrosine Kinase Activity Cell-cell Junction Response To Lipid Protein Binding Regulation Of Immune System Process Positive Regulation Of Multicellular Organismal Process Cell Migration Water Channel Activity Peptidyl-tyrosine Phosphorylation Cell Activation Apoptotic Signaling Pathway Regulation Of Protein Localization Protein O-linked Glycosylation Protein Tyrosine Kinase Activator Activity Fc Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Fc-gamma Receptor Signaling Pathway Basolateral Plasma Membrane Regulation Of Cell-cell Adhesion Immune Response-activating Cell Surface Receptor Signaling Pathway Perinuclear Region Of Cytoplasm Regulation Of Fibroblast Proliferation Lymphocyte Activation Regulation Of Multicellular Organismal Process Golgi Apparatus Regulation Of Cell Activation Renal Water Homeostasis Schwann Cell Development Positive Regulation Of Protein Localization To Centrosome Glycerol Transmembrane Transport Protein Phosphatase Binding Myelination
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