BCL2L13 and CERS6

Number of citations of the paper that reports this interaction (PubMedID 24706805)
34

Data Source:
BioGRID (affinity chromatography technology, pull down)

		BCL2L13	CERS6
Description		BCL2 like 13	ceramide synthase 6
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Membrane Mitochondrial Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process	DNA Binding Protein Binding Transferase Activity Sphingosine N-acyltransferase Activity
	Biological Process	Mitophagy Oxidative Phosphorylation Apoptotic Process Mitochondrion Organization Regulation Of Apoptotic Process Fat Cell Differentiation Canonical Glycolysis	Lipid Metabolic Process Sphingolipid Metabolic Process Inflammatory Response Oligodendrocyte Development Sphingolipid Biosynthetic Process Ceramide Biosynthetic Process Positive Regulation Of Oligodendrocyte Apoptotic Process
Pathways			Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Baseline cortisol levels in response to low dose short synacthen test in corticosteroid treated asthma ( 29551627) Eosinophil count ( 32888494) Granulocyte count ( 27863252) Hemoglobin levels ( 32327693) Interleukin-10 levels ( 22205395) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Neutrophil percentage of white cells ( 32888494) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494)	Bipolar disorder ( 31043756 34002096) Parkinson's disease ( 27182965) Recurrent major depressive disorder ( 34099189) Recurrent major depressive disorder x sex interaction ( 34099189) Red cell distribution width ( 27863252 28957414 32888494) Skin aging (microtopography measurement) ( 28502801) Thyroid stimulating hormone levels ( 32769997) Triglyceride levels ( 32203549)
Interacting Genes		84 interacting genes: ACP5 ADIPOQ AGTRAP AIG1 APOD APP AQP1 ARL6IP1 ARLN BAZ2B BCL9 BET1 CAMLG CD53 CDC42 CDK5R1 CERS6 CLDN19 CRB3 DEFB127 ERG28 ERMP1 ETNK2 FAM210B FUS FXYD3 FZD7 GABARAPL2 GALNT2 GAST GTF2F1 HMOX2 HNRNPK IDI1 JAGN1 JPH4 LAT LAYN LPAR3 MAL MGMT MTNR1B NDRG4 NETO2 NINJ2 NR2C2AP NRBP1 PCBP1 PLLP PLN PLP1 PLPP4 PPT2 RPN2 SH3RF3 SLC30A8 SLC35A1 SLC35G5 SMARCD3 SMIM1 SPOCK1 SQLE SRSF3 STX12 STX8 TM6SF2 TMEM128 TMEM14C TMEM242 TMEM254 TMEM51 TMEM72 TMEM86A TMEM86B TMEM97 TMUB2 TNF TNMD TRARG1 TUBB UBC UPK1B VAMP3 VAMP4	5 interacting genes: AGTR1 BCL2L13 CERS2 OPRL1 SEC22B
Entrez ID		23786	253782
HPRD ID		09822	17258
Ensembl ID		ENSG00000099968	ENSG00000172292
Uniprot IDs		A0A087WTL4 A0A087WW80 A0A087WX97 A0A0A0MR90 A8K5Y4 B2RB43 B7Z238 B7Z737 E9PDD6 F2Z2C3 F6VJB4 Q9BXK5	Q6ZMG9
PDB IDs			8QZ6 8QZ7 9EOT
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Localization Within Membrane SNARE Complex Cellular Localization Response To Type II Interferon Structural Constituent Of Myelin Sheath Protein Binding Regulation Of Transport Alkenylglycerophosphocholine Hydrolase Activity Cellular Response To Type II Interferon SNAP Receptor Activity Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Organelle Fusion Regulation Of Cellular Localization Phagocytic Vesicle Membrane Raft Regulation Of Chemokine Production Protein Localization To Membrane Protein Localization To Cell Periphery Vesicle Fusion Vesicle Organization Organelle Membrane Fusion Negative Regulation Of Blood Circulation Vesicle Docking Regulation Of Establishment Of Protein Localization Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Protein Transport Response To Cytokine Protein Localization To Plasma Membrane Response To Peptide Positive Regulation Of Chemokine Production G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Membrane Raft Distribution Establishment Of Protein Localization To Membrane Recycling Endosome Organelle Localization By Membrane Tethering Membrane Raft Localization	Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Calcium-mediated Signaling Angiotensin Type I Receptor Activity Phospholipase C-activating Angiotensin-activated Signaling Pathway Bradykinin Receptor Binding Renin-angiotensin Regulation Of Aldosterone Production Nociceptin Receptor Activity Negative Regulation Of Schwann Cell Proliferation Involved In Axon Regeneration Negative Regulation Of Schwann Cell Migration Angiotensin Type II Receptor Activity Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin G Protein-coupled Opioid Receptor Activity Negative Regulation Of Glial Cell Migration Sphingosine N-acyltransferase Activity Regulation Of Lipid Metabolic Process Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Regulation Of Renal Sodium Excretion Neuron-neuron Synaptic Transmission G Protein-coupled Opioid Receptor Signaling Pathway Negative Regulation Of Autophagosome Assembly Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Negative Regulation Of Axon Regeneration Negative Regulation Of Schwann Cell Proliferation N-acyltransferase Activity Negative Regulation Of Neuron Projection Regeneration G Protein-coupled Receptor Activity Low-density Lipoprotein Particle Remodeling Positive Regulation Of Macrophage Derived Foam Cell Differentiation Angiotensin-activated Signaling Pathway Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Glycolytic Process Through Glucose-6-phosphate Oxidative Phosphorylation Glycolytic Process Through Fructose-6-phosphate Canonical Glycolysis Negative Regulation Of Glial Cell Proliferation Regulation Of Glial Cell Migration
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