SMIM1 and SLC26A11

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SMIM1	SLC26A11
Description		small integral membrane protein 1 (Vel blood group)	solute carrier family 26 member 11
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane	Nucleoplasm Lysosome Lysosomal Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Binding Protein Homodimerization Activity	Chloride Channel Activity Protein Binding Secondary Active Sulfate Transmembrane Transporter Activity Monoatomic Anion Transmembrane Transporter Activity Sulfate Transmembrane Transporter Activity Antiporter Activity Chloride:bicarbonate Antiporter Activity
	Biological Process		Monoatomic Ion Transport Oxalate Transport Transmembrane Transport Inorganic Anion Transmembrane Transport Sulfate Transmembrane Transport Chloride Transmembrane Transport
Pathways			Transport and metabolism of PAPS Inorganic anion exchange by SLC26 transporters
Drugs
Diseases
GWAS		Glycated hemoglobin levels ( 34059833) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 27863252 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494 27863252) Red cell distribution width ( 28957414 27863252 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)	Interleukin-1-receptor antagonist levels ( 22205395) Ischemic stroke ( 26732560)
Interacting Genes		58 interacting genes: ANKS6 AQP6 ASZ1 BCL2L13 BIK CD74 CISD2 COMT CPLX4 CREB3L1 CYB561 EBP ELOVL4 ERGIC3 FAM174A FAM209A FAM210B FCER1G FFAR2 FNDC9 GJA8 GJB5 HACD2 HSD17B13 ICAM3 JAGN1 KIR2DL3 LHFPL5 LRP10 LRRC4C MFF MFSD6 MUC1 NAALAD2 NDUFAF2 PVR REEP4 RELL2 RETREG3 SAR1A SCN3B SDC3 SIGLEC7 SLC10A6 SLC18A1 SLC26A11 STING1 STX1A TM4SF19 TMEM154 TMEM31 TMEM45B TMEM51 TMEM52B TMEM86B TMPRSS2 TMX2 ZDHHC15	3 interacting genes: C5AR2 CFTR SMIM1
Entrez ID		388588	284129
HPRD ID			11569
Ensembl ID		ENSG00000235169	ENSG00000181045
Uniprot IDs		B2RUZ4 M4WDD3	Q86WA9
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Endoplasmic Reticulum Membrane Endoplasmic Reticulum Negative Regulation Of Peptide Secretion Monoamine Transport	Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Complement Component C5a Receptor Activity Positive Regulation Of Enamel Mineralization Complement Component C5a Signaling Pathway Transepithelial Water Transport Negative Regulation Of Neutrophil Chemotaxis Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Negative Regulation Of Neutrophil Migration Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Complement Receptor Activity Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Golgi-associated Vesicle Membrane Complement Receptor Mediated Signaling Pathway Cellular Response To Forskolin Response To Forskolin Chloride Transmembrane Transporter Activity Sperm Capacitation Negative Regulation Of Leukocyte Chemotaxis Cell Surface Bicarbonate Transport Water Transport Multicellular Organismal-level Water Homeostasis Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Ion Transmembrane Transporter Activity Cholesterol Biosynthetic Process 14-3-3 Protein Binding Fluid Transport Transepithelial Transport Regulation Of Neutrophil Chemotaxis Vesicle Docking Involved In Exocytosis Positive Regulation Of Transporter Activity ABC-type Transporter Activity Sterol Biosynthetic Process Regulation Of Neutrophil Migration Chloride Channel Complex Positive Regulation Of Biomineral Tissue Development Negative Regulation Of Chemotaxis Negative Regulation Of Interleukin-6 Production
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