TNFAIP8L3 and CBY1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TNFAIP8L3	CBY1
Description		TNF alpha induced protein 8 like 3	chibby 1, beta catenin antagonist
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Trans-Golgi Network Centrosome Centriole Cytosol Cytoskeleton Cilium Nuclear Speck Motile Cilium Ciliary Basal Body Sperm Flagellum Cell Projection
	Molecular Function	Protein Binding Phosphatidylinositol Transfer Activity Phosphatidylinositol Binding	Protein Binding Beta-catenin Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Phospholipid Metabolic Process Lipid Transport Phospholipid Transport Regulation Of Apoptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Intermembrane Lipid Transfer 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Metabolic Process	Intracellular Protein Localization Cell Projection Organization Cell Differentiation Negative Regulation Of Wnt Signaling Pathway Floor Plate Development Fat Cell Differentiation Negative Regulation Of DNA-templated Transcription Protein Homotetramerization Cardiac Muscle Cell Differentiation Canonical Wnt Signaling Pathway Cilium Assembly Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		PI Metabolism	Deactivation of the beta-catenin transactivating complex
Drugs
Diseases
GWAS		Airway wall thickness ( 25517131) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 33547301) Cognitive performance ( 20125193) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Keratoconus ( 33649486) Response to fenofibrate (HDL cholesterol levels) ( 27002377)	Resting heart rate ( 27798624) Sleep duration ( 30846698)
Interacting Genes		2 interacting genes: CBY1 SDCBP	18 interacting genes: AGTPBP1 CDK6 CFAP53 CIBAR1 CLU CTNNB1 DDIAS DZIP1L ENKD1 FAM161B GORASP2 LNX1 NBPF11 RALBP1 RASSF10 TNFAIP8L3 TSG101 TTC23L
Entrez ID		388121	25776
HPRD ID		13452	09676
Ensembl ID		ENSG00000183578	ENSG00000100211
Uniprot IDs		A0A1B0GTK8 Q5GJ75	Q9Y3M2
PDB IDs		4Q9V	4WRQ
Enriched GO Terms of Interacting Partners?		Cell Projection Assembly Interleukin-5 Receptor Binding Interleukin-5 Receptor Complex Positive Regulation Of Extracellular Exosome Assembly Plasma Membrane Bounded Cell Projection Assembly Syndecan Binding Regulation Of Extracellular Exosome Assembly Floor Plate Development Substrate-dependent Cell Migration, Cell Extension Negative Regulation Of Receptor Internalization Positive Regulation Of Exosomal Secretion Cytoskeletal Anchor Activity Regulation Of Exosomal Secretion Plasma Membrane Bounded Cell Projection Organization Frizzled Binding Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Projection Organization Negative Regulation Of Receptor-mediated Endocytosis Cardiac Muscle Cell Differentiation	Cytoskeleton Spindle Pole Ciliary Basal Body Cilium Cilium Organization Centriole Cytoplasm Centrosome Organelle Assembly Microtubule Cytoskeleton Cilium Assembly Establishment Of Organelle Localization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Organelle Organization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Plasma Membrane Bounded Cell Projection Assembly Cell Projection Assembly Ciliary Transition Zone Cell Projection Cyclin D3-CDK6 Complex T Cell Differentiation In Thymus Cyclin D1-CDK6 Complex Cyclin D2-CDK6 Complex Negative Regulation Of Myeloid Leukocyte Differentiation FBXO Family Protein Binding Establishment Of Protein Localization To Vacuole Perinuclear Endoplasmic Reticulum Lumen Positive Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Neuronal Signal Transduction Cellular Component Assembly Mesenchymal Stem Cell Differentiation Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Beta-catenin-ICAT Complex Positive Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Glial Cell Fate Determination Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Organelle Localization Renal Outer Medulla Development Renal Vesicle Formation Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Positive Regulation Of Branching Involved In Lung Morphogenesis Neural Plate Development Extracellular Transport Positive Regulation Of Ubiquitin-dependent Endocytosis Doxorubicin Transport
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