DTL and CUL4B

Number of citations of the paper that reports this interaction (PMID 23555860)
2

Data Source:
BioGRID (affinity chromatography technology, pull down)

		DTL	CUL4B
Gene Name		denticleless E3 ubiquitin protein ligase homolog (Drosophila)	cullin 4B
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Centrosome Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Nuclear Membrane Intracellular Membrane-bounded Organelle	Nucleoplasm Cytoplasm Plasma Membrane Cul4B-RING E3 Ubiquitin Ligase Complex Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding	Damaged DNA Binding Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Protein Polyubiquitination DNA Replication Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Response To UV Translesion Synthesis G2 DNA Damage Checkpoint Regulation Of Cell Cycle	Ubiquitin-dependent Protein Catabolic Process Cell Cycle Histone H2A Monoubiquitination Positive Regulation Of Protein Catabolic Process UV-damage Excision Repair Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Drugs
Diseases
GWAS		Height ( 20881960)
Protein-Protein Interactions		11 interactors: ATR CDT1 CHEK1 CUL4B DDB1 KAT2A PCNA SETD8 TDG TOB1 UBE2D1	22 interactors: AHR APP AR CAND1 COMMD1 DCUN1D1 DCUN1D3 DCUN1D4 DCUN1D5 DDB1 DDB2 DTL ESR1 KPNA2 KPNA4 KPNB1 NEDD8 RBX1 RNF7 SALL2 SIN3A UBC
Entrez ID		51514	8450
HPRD ID		17952	02251
Ensembl ID		ENSG00000143476	ENSG00000158290
Uniprot IDs		F5GZ90 Q9NZJ0	Q13620
PDB IDs			2DO7 4A0C 4A0L 4A64
Enriched GO Terms of Interacting Partners?		Cellular Response To UV Cellular Response To Light Stimulus Chromosome Organization DNA Metabolic Process DNA Repair Chromatin Modification Response To UV Chromatin Organization Cellular Response To Radiation Histone Modification Cell Cycle Nucleobase-containing Compound Metabolic Process Cellular Response To DNA Damage Stimulus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Stress Regulation Of Cell Cycle Process Cellular Nitrogen Compound Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Cell Cycle Process UV-damage Excision Repair Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process DNA Replication Mitotic Cell Cycle Process Organelle Organization Negative Regulation Of Biosynthetic Process Response To Light Stimulus Mitotic Cell Cycle Histone H2A Monoubiquitination Histone H2A Ubiquitination Regulation Of DNA Replication Regulation Of Response To DNA Damage Stimulus Regulation Of Mitotic Cell Cycle Replicative Senescence Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Cell Cycle Macromolecule Biosynthetic Process Response To Radiation Histone Monoubiquitination Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Abiotic Stimulus Regulation Of Metabolic Process Histone Ubiquitination Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process	Protein Modification By Small Protein Conjugation Protein Monoubiquitination Protein Neddylation Protein Ubiquitination Intracellular Receptor Signaling Pathway NLS-bearing Protein Import Into Nucleus Regulation Of Transcription From RNA Polymerase II Promoter DNA Metabolic Process Positive Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Response To UV Cellular Macromolecule Catabolic Process Response To Light Stimulus Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly UV-damage Excision Repair Positive Regulation Of Transcription From RNA Polymerase II Promoter Prostate Gland Development Response To Abiotic Stimulus Nucleobase-containing Compound Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Response To Radiation Regulation Of Cell Cycle Phase Transition Histone H2A Monoubiquitination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Modification-dependent Protein Catabolic Process Cellular Response To Stimulus Histone H2A Ubiquitination Cellular Nitrogen Compound Metabolic Process Positive Regulation Of DNA-templated Transcription, Initiation Viral Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Cellular Protein Catabolic Process Nucleotide-excision Repair, DNA Damage Removal Cellular Response To Organic Substance Rhythmic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Import Into Nucleus Histone Monoubiquitination DNA Repair Nuclear Import Regulation Of DNA-templated Transcription, Initiation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Catabolic Process Copper Ion Homeostasis Regulation Of Apoptotic Process
Tagcloud ?		59f5 arm chaperone close closely cluster consisting describe dm dnaj drosophila encodes evolution homolog homology hs hsp90 interspaced isolation kb lethal locus melanogaster nested putative shock spanning temporal tid	absent alleviate assemble augmented blunted dampening depleted downregulated drives driving e3 ectopic exacerbate feedback greatly h2o2 ligases loop mildly negatively nhfs oxidative proteosomal replicative ros senescence senescent stressed ubiquitination
Tagcloud (Difference) ?		59f5 arm chaperone close closely cluster consisting describe dm dnaj drosophila encodes evolution homolog homology hs hsp90 interspaced isolation kb lethal locus melanogaster nested putative shock spanning temporal tid	absent alleviate assemble augmented blunted dampening depleted downregulated drives driving e3 ectopic exacerbate feedback greatly h2o2 ligases loop mildly negatively nhfs oxidative proteosomal replicative ros senescence senescent stressed ubiquitination
Tagcloud (Intersection) ?