REP15 and GNG11

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		REP15	GNG11
Description		RAB15 effector protein	G protein subunit gamma 11
Image			No pdb structure
GO Annotations	Cellular Component	Endosome Endosome Membrane Membrane Early Endosome Membrane Perinuclear Region Of Cytoplasm Recycling Endosome	Heterotrimeric G-protein Complex Plasma Membrane Membrane
	Molecular Function	Protein Binding	GTPase Activity Protein Binding G-protein Beta-subunit Binding
	Biological Process	Receptor Recycling Transferrin Transport	Signal Transduction G Protein-coupled Receptor Signaling Pathway
Pathways			Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs
Diseases
GWAS			Heart rate ( 23583979) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Heart rate variability traits (pvRSA/HF) ( 28613276) Heart rate variability traits (RMSSD) ( 28613276) Heart rate variability traits (SDNN) ( 28613276) Mosquito bite size ( 28199695) Resting heart rate ( 27798624)
Interacting Genes		9 interacting genes: ARID3A GNG11 RAB15 RAB34 RAB3A RAB3C RAB3D ZRSR2 ZRSR2P1	9 interacting genes: AMOTL2 CEP44 FOS GNB1 GNB4 MEOX2 REP15 SMURF1 ZHX1
Entrez ID		387849	2791
HPRD ID		18804	11979
Ensembl ID		ENSG00000174236	ENSG00000127920
Uniprot IDs		Q6BDI9	P61952 Q53Y01
PDB IDs		8A4A 8A4B 8A4C
Enriched GO Terms of Interacting Partners?		GTP-dependent Protein Binding GTPase Activity Myosin V Binding GTP Binding Regulation Of Exocytosis Positive Regulation Of Regulated Secretory Pathway Exocytosis Pre-mRNA 3'-splice Site Binding U2AF Complex Positive Regulation Of Exocytosis Secretion By Cell Regulation Of Regulated Secretory Pathway Synaptic Vesicle Secretion Vesicle Protein Transport Regulation Of Vesicle-mediated Transport Regulation Of Secretion By Cell Vesicle-mediated Transport Regulation Of Secretion Establishment Of Protein Localization Perinuclear Region Of Cytoplasm Lysosome Localization Positive Regulation Of Secretion By Cell Metal Ion Binding Regulation Of Presynaptic Dense Core Granule Exocytosis Positive Regulation Of Secretion Evoked Neurotransmitter Secretion Hydrolase Activity Nucleotide Binding Intracellular Protein Localization Sensory Perception Of Touch Antigen Processing And Presentation Clathrin-sculpted Acetylcholine Transport Vesicle Membrane Regulation Of Dense Core Granule Exocytosis Zymogen Granule Clathrin-sculpted Glutamate Transport Vesicle Membrane Acrosomal Vesicle Exocytosis Clathrin-sculpted Monoamine Transport Vesicle Membrane Constitutive Secretory Pathway Cytosolic Ciliogenesis Regulation Of Plasma Membrane Repair Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Macropinocytosis Spliceosomal Complex Synaptic Vesicle Maturation Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Maintenance Of Presynaptic Active Zone Structure MRNA Splicing, Via Spliceosome Secretory Vesicle	R-SMAD Binding Signaling Receptor Complex Adaptor Activity Heterotrimeric G-protein Complex Receptor Metabolic Process Medium-term Memory Cellular Response To Prolactin Engulfment Of Target By Autophagosome Protein-containing Complex Binding
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