NPSR1 and TMED10

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		NPSR1	TMED10
Description		neuropeptide S receptor 1	transmembrane p24 trafficking protein 10
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cis-Golgi Network Plasma Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle COPII-coated ER To Golgi Transport Vesicle COPI-coated Vesicle Trans-Golgi Network Transport Vesicle Transport Vesicle Membrane Secretory Granule Membrane Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Melanosome Zymogen Granule Membrane Gamma-secretase Complex
	Molecular Function	G Protein-coupled Receptor Activity Vasopressin Receptor Activity Neuropeptide Receptor Activity	Protein Binding Protein Transmembrane Transporter Activity Syntaxin Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Eating Behavior Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Righting Reflex Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Eating Behavior Negative Regulation Of Defecation	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Golgi Organization Protein Transport Vesicle-mediated Transport Positive Regulation Of Interleukin-1 Production Vesicle Cargo Loading COPI-coated Vesicle Budding Regulated Exocytosis Vesicle Targeting, To, From Or Within Golgi COPI Coating Of Golgi Vesicle COPII Vesicle Coating Positive Regulation Of Protein Secretion Protein Transmembrane Transport Protein Localization To ERGIC Cytosol To ERGIC Protein Transport Regulation Of Amyloid-beta Formation
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events G alpha (s) signalling events	COPII-mediated vesicle transport Cargo concentration in the ER COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs		Halothane
Diseases
GWAS		Anti-chlamydia trachomatis IgG seropositivity ( 29967566) Asthma ( 29273806) Leisure-time exercise behaviour ( 30102679) Plasma anti-thyroglobulin levels ( 29678681) Uterine fibroid number (single vs multiple) ( 30196971)	Coronary artery disease ( 32469254) Heel bone mineral density ( 30598549) Height ( 19343178) Refractive error ( 32231278)
Interacting Genes		16 interacting genes: ATP5F1A CCT2 ENTPD6 GABARAPL2 HLA-C IPO13 PGM2L1 PMPCB PRR36 RABGGTB SLC3A2 SLC41A3 SLC75A1 TERF2IP TMED10 TMEM101	20 interacting genes: APH1A ARCN1 ARF1 CDC42 CEBPA COPA COPB1 COPB2 COPE COPG1 COPG2 COPZ1 DHODH FBXO7 NCSTN NPSR1 PSENEN SEC23B SLC13A1 TMED2
Entrez ID		387129	10972
HPRD ID		10547	12013
Ensembl ID		ENSG00000187258	ENSG00000170348
Uniprot IDs		A0A090N8Z1 Q6W5P4	A0A024R6I3 P49755
PDB IDs
Enriched GO Terms of Interacting Partners?		Mitochondrial Processing Peptidase Complex Protein Processing Involved In Protein Targeting To Mitochondrion Mitochondrial Protein Processing Adenyl Ribonucleotide Binding Transmembrane Transport Guanosine-5'-triphosphate,3'-diphosphate Diphosphatase Activity Apical Pole Of Neuron Tetracycline Transmembrane Transport Tetracycline Transmembrane Transporter Activity Cytosol To ERGIC Protein Transport Protein Localization To ERGIC COPI-coated Vesicle Budding Glucose-1,6-bisphosphate Synthase Activity	COPI-coated Vesicle Membrane COPI Vesicle Coat Golgi Membrane Transport Vesicle COPI-coated Vesicle Intra-Golgi Vesicle-mediated Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Vesicle Transport Membrane Coat Endoplasmic Reticulum Membrane Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intracellular Transport Intracellular Protein Transport Golgi Apparatus Cytoplasmic Vesicle Vesicle-mediated Transport Cellular Localization Establishment Of Localization In Cell Establishment Of Protein Localization Protein Transport Gamma-secretase Complex Structural Molecule Activity Notch Receptor Processing Amyloid-beta Formation Intracellular Protein Localization Membrane Protein Intracellular Domain Proteolysis Golgi Localization Amyloid Precursor Protein Catabolic Process Endopeptidase Activator Activity Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Protein Ectodomain Proteolysis Amyloid Precursor Protein Metabolic Process Amyloid-beta Metabolic Process Membrane Membrane Protein Proteolysis Notch Signaling Pathway Establishment Of Golgi Localization Endoplasmic Reticulum Golgi Cisterna Membrane Protein Localization To Axon Organelle Transport Along Microtubule Embryonic Placenta Development Protein Secretion Protein Localization To Extracellular Region Establishment Of Protein Localization To Extracellular Region Presynaptic Membrane Vesicle Cargo Loading Dendritic Spine Organization Mitotic Cleavage Furrow Ingression RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding
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