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ALOX12B and KRT5
Number of citations of the paper that reports this interaction (PMID
10727209
)
7
Data Source:
HPRD
(in vivo, two hybrid)
ALOX12B
KRT5
Gene Name
arachidonate 12-lipoxygenase, 12R type
keratin 5, type II
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytosol
Nucleus
Cytoplasm
Mitochondrion
Cytosol
Intermediate Filament
Plasma Membrane
Membrane
Keratin Filament
Extracellular Vesicular Exosome
Molecular Function
Arachidonate 12-lipoxygenase Activity
Iron Ion Binding
Protein Binding
Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen
Linoleate 9S-lipoxygenase Activity
Structural Constituent Of Cytoskeleton
Protein Binding
Scaffold Protein Binding
Biological Process
Protein Lipidation
Sphingolipid Metabolic Process
Positive Regulation Of Gene Expression
Arachidonic Acid Metabolic Process
Lipoxygenase Pathway
Positive Regulation Of MAPK Cascade
Linoleic Acid Metabolic Process
Small Molecule Metabolic Process
Ceramide Biosynthetic Process
Hepoxilin Biosynthetic Process
Oxidation-reduction Process
Establishment Of Skin Barrier
Positive Regulation Of Mucus Secretion
Epidermis Development
Hemidesmosome Assembly
Cell Junction Assembly
Pathways
Arachidonic acid metabolism
Metabolism of lipids and lipoproteins
Synthesis of 12-eicosatetraenoic acid derivatives
Cell junction organization
Type I hemidesmosome assembly
Drugs
Diseases
GWAS
Protein-Protein Interactions
2 interactors:
KRT5
LMNA
19 interactors:
ALOX12
ALOX12B
APC
DSP
DST
EVPL
KIFC3
KRT1
KRT14
KRT15
KRT18
KRT31
KRT38
KRT40
PKP2
SUMO1
SUMO2
SUMO3
TCHP
Entrez ID
242
3852
HPRD ID
04772
01010
Ensembl ID
ENSG00000179477
ENSG00000186081
Uniprot IDs
O75342
P13647
PDB IDs
3TNU
Enriched GO Terms of Interacting Partners
?
Sterol Regulatory Element Binding Protein Import Into Nucleus
Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity
Positive Regulation Of Cell Aging
Mitotic Nuclear Envelope Reassembly
Nuclear Envelope Reassembly
Hemidesmosome Assembly
SREBP Signaling Pathway
Response To Sterol Depletion
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Ventricular Cardiac Muscle Cell Development
Ventricular Cardiac Muscle Cell Differentiation
Negative Regulation Of Mitochondrion Organization
Mitotic Nuclear Envelope Disassembly
Nuclear Envelope Disassembly
Cell-substrate Junction Assembly
Activation Of Signaling Protein Activity Involved In Unfolded Protein Response
Positive Regulation Of Nuclease Activity
Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
Tissue Development
Nuclear Envelope Organization
Cardiac Muscle Cell Development
Execution Phase Of Apoptosis
Endoplasmic Reticulum Unfolded Protein Response
Regulation Of Mitochondrion Organization
Cellular Response To Hypoxia
Cellular Response To Unfolded Protein
Cellular Response To Decreased Oxygen Levels
ER-nucleus Signaling Pathway
Cellular Response To Oxygen Levels
Cellular Response To Topologically Incorrect Protein
Cardiac Muscle Cell Differentiation
Protein Import Into Nucleus
Nucleus Organization
Nuclear Import
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Response To Unfolded Protein
Cardiocyte Differentiation
Intermediate Filament Cytoskeleton Organization
Intermediate Filament-based Process
Skin Development
Epidermis Development
Establishment Of Skin Barrier
Intermediate Filament Organization
Regulation Of Water Loss Via Skin
Protein Sumoylation
Multicellular Organismal Water Homeostasis
Hepoxilin Metabolic Process
Hepoxilin Biosynthetic Process
Intermediate Filament Bundle Assembly
Cell Junction Assembly
Water Homeostasis
Bundle Of His Cell To Purkinje Myocyte Communication
Anatomical Structure Development
Cell-cell Junction Organization
Positive Regulation Of Protein Catabolic Process
Linoleic Acid Metabolic Process
Desmosome Organization
Hemidesmosome Assembly
Lipoxygenase Pathway
Developmental Process
Positive Regulation Of Proteolysis
Epithelium Development
Long-chain Fatty Acid Biosynthetic Process
Regulation Of Proteolysis
Cytoskeleton Organization
Ventricular Cardiac Muscle Cell Action Potential
Tissue Development
Regulation Of Heart Rate By Cardiac Conduction
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Catabolic Process
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Component Maintenance
Positive Regulation Of Cellular Protein Catabolic Process
Cardiac Muscle Cell Action Potential Involved In Contraction
Cardiac Muscle Cell Action Potential
Regulation Of Proteasomal Protein Catabolic Process
Post-translational Protein Modification
Single Organismal Cell-cell Adhesion
Apoptotic Process
Regulation Of Cardiac Muscle Cell Contraction
Ventricular Cardiac Muscle Tissue Morphogenesis
Cardiac Conduction
Peptide Cross-linking
Programmed Cell Death
Cell-substrate Junction Assembly
Cell Death
Death
Tagcloud
?
aldh1
ciliated
columnar
exposes
foxj1
gynaecological
hgsc
hgscs
krt7
layered
lef1
mem
membraneous
nests
outgrowths
oviduct
oviductal
oviducts
pax2
pseudostratified
rcn1
scout
scouts
stathmin
stins
tubal
walthard
wcn
wcns
Tagcloud (Difference)
?
aldh1
ciliated
columnar
exposes
foxj1
gynaecological
hgsc
hgscs
krt7
layered
lef1
mem
membraneous
nests
outgrowths
oviduct
oviductal
oviducts
pax2
pseudostratified
rcn1
scout
scouts
stathmin
stins
tubal
walthard
wcn
wcns
Tagcloud (Intersection)
?