ALOX12B

Description		arachidonate 12-lipoxygenase, 12R type
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Arachidonate 12(S)-lipoxygenase Activity Iron Ion Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Lyase Activity Isomerase Activity Metal Ion Binding Arachidonate 8(R)-lipoxygenase Activity Dioxygenase Activity Arachidonate 12(R)-lipoxygenase Activity Linoleate 9S-lipoxygenase Activity
	Biological Process	Protein Lipidation Lipid Metabolic Process Fatty Acid Metabolic Process Sphingolipid Metabolic Process Positive Regulation Of Gene Expression Arachidonate Metabolic Process Lipoxygenase Pathway Lipid Oxidation Positive Regulation Of MAPK Cascade Linoleic Acid Metabolic Process Ceramide Biosynthetic Process Hepoxilin Biosynthetic Process Establishment Of Skin Barrier Positive Regulation Of Mucus Secretion
Pathways		Synthesis of 12-eicosatetraenoic acid derivatives
Drugs
Diseases		Lamellar ichthyosis (LI) and Non-bullous congenital ichthyosiform erythroderma (NBCIE)
GWAS
Interacting Genes		2 interacting genes: KRT5 LMNA
Entrez ID		242
HPRD ID		04772
Ensembl ID		ENSG00000179477
Uniprot IDs		O75342
PDB IDs
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Cytoskeleton Intermediate Filament Polymerization Intermediate Filament Intermediate Filament Polymerization Or Depolymerization DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Lamin Filament Nuclear Pore Localization Negative Regulation Of Mesenchymal Cell Proliferation Ventricular Cardiac Muscle Cell Development Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Nuclear Lamina Protein Localization To Nuclear Envelope Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Protein Localization Nuclear Envelope Organization Cytoskeleton Organization Regulation Of Cell Migration Nuclear Migration Regulation Of Cell Motility Nucleus Localization Regulation Of Locomotion Regulation Of Mesenchymal Cell Proliferation Nuclear Lumen Negative Regulation Of Muscle Hypertrophy Cardiac Muscle Cell Development Negative Regulation Of Cardiac Muscle Hypertrophy Regulation Of Release Of Cytochrome C From Mitochondria Cardiac Cell Development Structural Constituent Of Skin Epidermis Scaffold Protein Binding Keratinization Intermediate Filament Organization Striated Muscle Cell Development Protein-containing Complex Localization Regulation Of Cardiac Muscle Hypertrophy Cellular Senescence Protein Polymerization Chromosome Localization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Nucleus Organization Muscle Cell Development Site Of Double-strand Break Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Telomere Maintenance Regulation Of Mitochondrion Organization
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