ALOX12B

Gene Name		arachidonate 12-lipoxygenase, 12R type
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol
	Molecular Function	Arachidonate 12-lipoxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Linoleate 9S-lipoxygenase Activity
	Biological Process	Protein Lipidation Sphingolipid Metabolic Process Positive Regulation Of Gene Expression Arachidonic Acid Metabolic Process Lipoxygenase Pathway Positive Regulation Of MAPK Cascade Linoleic Acid Metabolic Process Small Molecule Metabolic Process Ceramide Biosynthetic Process Hepoxilin Biosynthetic Process Oxidation-reduction Process Establishment Of Skin Barrier Positive Regulation Of Mucus Secretion
Pathways		Arachidonic acid metabolism Metabolism of lipids and lipoproteins Synthesis of 12-eicosatetraenoic acid derivatives
Drugs
Diseases
GWAS
Protein-protein Interactions		2 interactors: KRT5 LMNA
Entrez ID		242
HPRD ID		04772
Ensembl ID		ENSG00000179477
Uniprot IDs		O75342
PDB IDs
Enriched GO Terms of Interacting Partners?		Sterol Regulatory Element Binding Protein Import Into Nucleus Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Positive Regulation Of Cell Aging Mitotic Nuclear Envelope Reassembly Nuclear Envelope Reassembly Hemidesmosome Assembly SREBP Signaling Pathway Response To Sterol Depletion Negative Regulation Of Release Of Cytochrome C From Mitochondria Ventricular Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Differentiation Negative Regulation Of Mitochondrion Organization Mitotic Nuclear Envelope Disassembly Nuclear Envelope Disassembly Cell-substrate Junction Assembly Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Nuclease Activity Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Tissue Development Nuclear Envelope Organization Cardiac Muscle Cell Development Execution Phase Of Apoptosis Endoplasmic Reticulum Unfolded Protein Response Regulation Of Mitochondrion Organization Cellular Response To Hypoxia Cellular Response To Unfolded Protein Cellular Response To Decreased Oxygen Levels ER-nucleus Signaling Pathway Cellular Response To Oxygen Levels Cellular Response To Topologically Incorrect Protein Cardiac Muscle Cell Differentiation Protein Import Into Nucleus Nucleus Organization Nuclear Import Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Unfolded Protein Cardiocyte Differentiation
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