SHOC2

Description		SHOC2 leucine rich repeat scaffold protein
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GO Annotations	Cellular Component	Protein Phosphatase Type 1 Complex Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Protein Phosphatase 1 Binding Protein Phosphatase Regulator Activity Protein Phosphatase Binding
	Biological Process	Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Neuron Projection Development Intracellular Signal Transduction Nerve Growth Factor Signaling Pathway Regulation Of MAPK Cascade Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Ras Protein Signal Transduction Cellular Response To Growth Hormone Stimulus Cyclic-GMP-AMP Transmembrane Import Across Plasma Membrane Negative Regulation Of Neural Precursor Cell Proliferation
Pathways		RAF activation SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling
Drugs
Diseases		Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS		Fish- and plant-related diet ( 32066663)
Interacting Genes		10 interacting genes: APP ERBIN FBXW7 HRAS KRAS NRAS OGT PSMC5 RAF1 USP7
Entrez ID		8036
HPRD ID		04144
Ensembl ID		ENSG00000108061
Uniprot IDs		Q9UQ13
PDB IDs		7SD0 7SD1 7T7A 7TVF 7TVG 7TXH 7TYG 7UPI
Enriched GO Terms of Interacting Partners?		Glial Cell Development Intracellular Signal Transduction Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Proteolysis Regulation Of Protein Catabolic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Programmed Cell Death Regulation Of Proteasomal Protein Catabolic Process Regulation Of Neuronal Synaptic Plasticity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process MAPK Cascade G Protein Activity Regulation Of Neuron Apoptotic Process Regulation Of Biological Quality GDP Binding Ras Protein Signal Transduction Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Schwann Cell Development Positive Regulation Of Metabolic Process Apoptotic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Intracellular Signaling Cassette Regulation Of Gene Expression Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Cell Development Negative Regulation Of Biosynthetic Process Regulation Of Cell Communication Response To Radiation Negative Regulation Of Cell Communication Regulation Of Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Regulation Of Protein Localization Positive Regulation Of MAPK Cascade Programmed Cell Death
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