MT-CYB and MVP

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		MT-CYB	MVP
Description		cytochrome b	major vault protein
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Protein-containing Complex Respiratory Chain Complex III	Extracellular Region Nucleus Nuclear Pore Cytoplasm Cytosol Cytoskeleton Membrane Secretory Granule Lumen Perinuclear Region Of Cytoplasm Extracellular Exosome Ficolin-1-rich Granule Lumen Ribonucleoprotein Complex
	Molecular Function	Quinol-cytochrome-c Reductase Activity Electron Transfer Activity Oxidoreductase Activity Protein-containing Complex Binding Metal Ion Binding	Protein Binding Protein Kinase Binding Protein Phosphatase Binding Identical Protein Binding
	Biological Process	Response To Hypoxia Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Response To Nutrient Response To Xenobiotic Stimulus Response To Toxic Substance Response To Hormone Electron Transport Coupled Proton Transport Respiratory Electron Transport Chain Animal Organ Regeneration Response To Cobalamin Response To Glucagon Cellular Respiration Response To Ethanol Response To Cadmium Ion Response To Copper Ion Response To Mercury Ion Response To Calcium Ion Response To Hyperoxia Response To D-galactosamine	Cell Population Proliferation Protein Transport Negative Regulation Of Protein Autophosphorylation ERBB Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway MRNA Transport Negative Regulation Of Protein Tyrosine Kinase Activity Protein Activation Cascade
Pathways		Mitochondrial translation termination Respiratory electron transport Complex III assembly Complex III assembly	Neutrophil degranulation
Drugs		2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol 6-Hydroxy-5-undecyl-4,7-benzothiazoledione Azoxystrobin 5-Heptyl-6-hydroxy-1,3-benzothiazole-4,7-dione (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE (S)-famoxadone METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE 2-Nonyl-4-quinolinol 1-oxide Ubiquinone Q2
Diseases		Leber optic atrophy; Leber hereditary optic atrophy (LHON)
GWAS			Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		2 interacting genes: KRAS MVP	69 interacting genes: ADAMTSL4 BANP C1orf94 CALCOCO2 CAMK2B CKAP4 DISC1 DLX2 DTX2 EPHX2 ESR1 FMR1 FNDC3B FXR1 FXR2 GIT2 GOLGA2 HP HSPA13 IHO1 KCTD9 KPNA2 KPNA3 MDFI MEOX1 MEOX2 MID2 MRTFA MT-CYB NNT NOTCH2NLA NRF1 NTAQ1 PARP4 PIH1D2 PLSCR1 POT1 PSTPIP1 PTEN PTPN11 RAB3IP RBPMS REL RHOXF2 RIMBP3 RNF10 RNF111 SAXO1 SERTAD1 SKIL SLC2A4 STN1 TCF4 TENT5C TFCP2 TLE5 TOLLIP TP53 TRAF2 TRIM27 TRIM42 TRIP13 TRIP6 TSPOAP1 UBC UBTD2 VAC14 ZBTB32 ZMIZ2
Entrez ID		4519	9961
HPRD ID		02468	05475
Ensembl ID		ENSG00000198727	ENSG00000013364
Uniprot IDs		P00156 Q0ZFD6	Q14764 X5D2M8 X5D7K9 X5DNU0
PDB IDs		5XTE 5XTH 5XTI	1Y7X 9BW5 9BW6 9BW7 9MXH 9MXV
Enriched GO Terms of Interacting Partners?		Response To Isolation Stress GMP Binding Forebrain Astrocyte Development Negative Regulation Of Protein Autophosphorylation LRR Domain Binding Cardiac Muscle Cell Proliferation Lung Epithelial Cell Differentiation Positive Regulation Of Cellular Senescence Rac Protein Signal Transduction Myoblast Proliferation Type I Pneumocyte Differentiation Positive Regulation Of Rac Protein Signal Transduction Positive Regulation Of Glial Cell Proliferation Response To Gravity Astrocyte Development Glial Cell Proliferation Lung Cell Differentiation Epithelial Tube Branching Involved In Lung Morphogenesis Cell Population Proliferation Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Peptidyl-tyrosine Phosphorylation Protein Activation Cascade Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Protein Tyrosine Kinase Activity Regulation Of Protein Tyrosine Kinase Activity Regulation Of Protein Autophosphorylation Regulation Of Synaptic Transmission, GABAergic Regulation Of Rac Protein Signal Transduction Protein-membrane Adaptor Activity Negative Regulation Of ERBB Signaling Pathway Response To Mineralocorticoid Homeostasis Of Number Of Cells Within A Tissue Regulation Of Glial Cell Proliferation Muscle Cell Proliferation Regulation Of Cellular Senescence Negative Regulation Of Epithelial Cell Differentiation Visual Learning Visual Behavior Regulation Of Neuronal Synaptic Plasticity GDP Binding Positive Regulation Of Gliogenesis G Protein Activity Skeletal Muscle Cell Differentiation Glial Cell Development Striated Muscle Cell Differentiation Female Pregnancy Positive Regulation Of Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Negative Regulation Of Kinase Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway	Identical Protein Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Biosynthetic Process Cytoplasm Regulation Of Neurogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity PML Body Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Nervous System Development Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleus Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Translation Regulator Activity Regulation Of Neuronal Synaptic Plasticity TFIIB-class Transcription Factor Binding Viral Penetration Into Host Nucleus Negative Regulation Of Telomere Maintenance Via Telomerase Benzodiazepine Receptor Binding Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II RNA Strand Annealing Activity Regulation Of MiRNA-mediated Gene Silencing Somite Specification Dentate Gyrus Development Single-stranded Telomeric DNA Binding MRNA 3'-UTR Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Post-transcriptional Gene Silencing Regulation Of Macromolecule Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Regulation Of Viral Process Protein Binding Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Chromosome Organization Positive Regulation Of Neurogenesis Intracellular Membraneless Organelle Presynapse Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Catabolic Process
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