KPNA4 and NUP50

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		KPNA4	NUP50
Gene Name		karyopherin alpha 4 (importin alpha 3)	nucleoporin 50kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol Extracellular Vesicular Exosome	Nuclear Pore Nucleoplasm Cytoplasm Nuclear Membrane
	Molecular Function	Protein Binding Protein Transporter Activity	Protein Binding
	Biological Process	NLS-bearing Protein Import Into Nucleus Cytokine-mediated Signaling Pathway Response To Hydrogen Peroxide	Mitotic Cell Cycle Carbohydrate Metabolic Process Mitotic Nuclear Envelope Disassembly Hexose Transport Pathogenesis Gene Expression Regulation Of Glucose Transport Protein Transport Glucose Transport Viral Process Viral Life Cycle Viral Transcription Cytokine-mediated Signaling Pathway Small Molecule Metabolic Process Intracellular Transport MRNA Transport Transmembrane Transport
Pathways		ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes	Mitotic Prophase HIV Infection Nuclear import of Rev protein Regulatory RNA pathways Rev-mediated nuclear export of HIV RNA Nuclear Envelope Breakdown SLC-mediated transmembrane transport M Phase Influenza Life Cycle HIV Life Cycle Influenza Viral RNA Transcription and Replication Rev-mediated nuclear export of HIV RNA Myoclonic epilepsy of Lafora Glycogen storage diseases Transcriptional regulation by small RNAs Vpr-mediated nuclear import of PICs ISG15 antiviral mechanism Interferon Signaling Host Interactions of HIV factors Nuclear Pore Complex (NPC) Disassembly Regulation of Glucokinase by Glucokinase Regulatory Protein Cytokine Signaling in Immune system Interactions of Vpr with host cellular proteins Interactions of Rev with host cellular proteins Influenza Infection Hexose transport Cell Cycle, Mitotic Late Phase of HIV Life Cycle Antiviral mechanism by IFN-stimulated genes Viral Messenger RNA Synthesis Metabolism of carbohydrates Glucose transport
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: APP CDKN1B CSE1L CSNK2A1 CUL4B CYHR1 EXO1 HNRNPC KPNB1 MAT2B NUP50 PLAA RAC1 RCC1 RECQL TGM2 TP53	13 interactors: APP CDKN1B IPO13 KPNA1 KPNA2 KPNA3 KPNA4 KPNA5 KPNA6 KPNB1 RAN SRPK2 XPO1
Entrez ID		3840	10762
HPRD ID		04275	05226
Ensembl ID		ENSG00000186432	ENSG00000093000
Uniprot IDs		O00629	Q9UKX7
PDB IDs			2EC1 3TJ3
Enriched GO Terms of Interacting Partners?		Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Process Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Cell Cycle Process Cell Cycle Cellular Response To Stimulus Regulation Of Cell Cycle Viral Process Positive Regulation Of Cell Cycle DNA Strand Renaturation Mitotic Cell Cycle Arrest Regulation Of Catalytic Activity Mitotic Cell Cycle Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Protein Metabolic Process Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Checkpoint Response To Stimulus Protein Import Into Nucleus, Translocation Nucleobase-containing Compound Metabolic Process Cellular Response To DNA Damage Stimulus Positive Regulation Of Protein Complex Assembly Apoptotic Cell Clearance Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Organelle Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Cell Surface Receptor Signaling Pathway Cell Cycle Process Cell Cycle Checkpoint DNA Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death DNA Repair Response To Abiotic Stimulus Regulation Of Growth Positive Regulation Of Cell Death DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Neuron Apoptotic Process	Protein Localization To Nucleus NLS-bearing Protein Import Into Nucleus Protein Import Into Nucleus Nuclear Import Nucleocytoplasmic Transport Nuclear Transport Protein Import Protein Localization To Organelle Establishment Of Protein Localization To Organelle Cytoplasmic Transport Protein Targeting Intracellular Protein Transport Intracellular Transport Of Virus Intracellular Transport Cellular Protein Localization Establishment Of Localization In Cell Protein Transport Establishment Of Protein Localization Cellular Localization Protein Localization Viral Life Cycle Cytokine-mediated Signaling Pathway Transport Viral Process Cellular Response To Cytokine Stimulus Ribosomal Small Subunit Export From Nucleus Response To Cytokine Cellular Response To Organic Substance Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Ribosomal Large Subunit Export From Nucleus Cell Communication Ribosomal Subunit Export From Nucleus Response To Organic Substance Cellular Response To Stimulus Apoptotic DNA Fragmentation Apoptotic Nuclear Changes Protein Export From Nucleus Response To Stimulus Positive Regulation Of Cell Cycle Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Nuclear Speck Organization Regulation Of DNA Recombination Ribonucleoprotein Complex Biogenesis Execution Phase Of Apoptosis Synaptic Growth At Neuromuscular Junction Viral Penetration Into Host Nucleus DNA Catabolic Process, Endonucleolytic Regulation Of Cell Cycle
Tagcloud ?		9k arrb1 atg14 atg4b cage1 cald1 cd9 chrna7 chrnb1 col1 expressional fn1 frap hey1 humn il10r il12 il13 il15 il27 immunochemical informational oas slc6a2 vegfc villi villous villus voluntarily	accompany als amyotrophic cytosolic degenerating deleterious deregulation disrupted dominantly drosophila elicited flies hey histopathologic inherited intercellular lifespan microarrays misregulation neurotoxicity notch nucleoporin paradigms paralysis signature spindleb tardbp tdp widespread
Tagcloud (Difference) ?		9k arrb1 atg14 atg4b cage1 cald1 cd9 chrna7 chrnb1 col1 expressional fn1 frap hey1 humn il10r il12 il13 il15 il27 immunochemical informational oas slc6a2 vegfc villi villous villus voluntarily	accompany als amyotrophic cytosolic degenerating deleterious deregulation disrupted dominantly drosophila elicited flies hey histopathologic inherited intercellular lifespan microarrays misregulation neurotoxicity notch nucleoporin paradigms paralysis signature spindleb tardbp tdp widespread
Tagcloud (Intersection) ?