NUP50 and KPNA3

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		NUP50	KPNA3
Gene Name		nucleoporin 50kDa	karyopherin alpha 3 (importin alpha 4)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Pore Nucleoplasm Cytoplasm Nuclear Membrane	Nuclear Pore Nucleoplasm Cytosol
	Molecular Function	Protein Binding	Protein Binding Protein C-terminus Binding Nuclear Localization Sequence Binding Protein Transporter Activity
	Biological Process	Mitotic Cell Cycle Carbohydrate Metabolic Process Mitotic Nuclear Envelope Disassembly Hexose Transport Pathogenesis Gene Expression Regulation Of Glucose Transport Protein Transport Glucose Transport Viral Process Viral Life Cycle Viral Transcription Cytokine-mediated Signaling Pathway Small Molecule Metabolic Process Intracellular Transport MRNA Transport Transmembrane Transport	Protein Complex Assembly NLS-bearing Protein Import Into Nucleus Cytokine-mediated Signaling Pathway Viral Entry Into Host Cell Viral Penetration Into Host Nucleus
Pathways		Mitotic Prophase HIV Infection Nuclear import of Rev protein Regulatory RNA pathways Rev-mediated nuclear export of HIV RNA Nuclear Envelope Breakdown SLC-mediated transmembrane transport M Phase Influenza Life Cycle HIV Life Cycle Influenza Viral RNA Transcription and Replication Rev-mediated nuclear export of HIV RNA Myoclonic epilepsy of Lafora Glycogen storage diseases Transcriptional regulation by small RNAs Vpr-mediated nuclear import of PICs ISG15 antiviral mechanism Interferon Signaling Host Interactions of HIV factors Nuclear Pore Complex (NPC) Disassembly Regulation of Glucokinase by Glucokinase Regulatory Protein Cytokine Signaling in Immune system Interactions of Vpr with host cellular proteins Interactions of Rev with host cellular proteins Influenza Infection Hexose transport Cell Cycle, Mitotic Late Phase of HIV Life Cycle Antiviral mechanism by IFN-stimulated genes Viral Messenger RNA Synthesis Metabolism of carbohydrates Glucose transport	ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes
Drugs
Diseases
GWAS			Menopause (age at onset) ( 22267201) Obesity-related traits ( 23251661)
Protein-Protein Interactions		13 interactors: APP CDKN1B IPO13 KPNA1 KPNA2 KPNA3 KPNA4 KPNA5 KPNA6 KPNB1 RAN SRPK2 XPO1	28 interactors: APOL6 CDKN1B COIL DDX21 EPHA2 ERCC3 FAM50B FTL GATA6 GTF2H1 HNRNPC KPNB1 MAT2B MTA1 MVP MYOD1 NFE2L2 NFKB1 NUP50 RCC1 RPRD1A SLC5A11 TEX37 TGM2 TSSC4 ZBTB24 ZCCHC10 ZNF131
Entrez ID		10762	3839
HPRD ID		05226	03536
Ensembl ID		ENSG00000093000	ENSG00000102753
Uniprot IDs		Q9UKX7	O00505 Q8IYQ9
PDB IDs		2EC1 3TJ3
Enriched GO Terms of Interacting Partners?		Protein Localization To Nucleus NLS-bearing Protein Import Into Nucleus Protein Import Into Nucleus Nuclear Import Nucleocytoplasmic Transport Nuclear Transport Protein Import Protein Localization To Organelle Establishment Of Protein Localization To Organelle Cytoplasmic Transport Protein Targeting Intracellular Protein Transport Intracellular Transport Of Virus Intracellular Transport Cellular Protein Localization Establishment Of Localization In Cell Protein Transport Establishment Of Protein Localization Cellular Localization Protein Localization Viral Life Cycle Cytokine-mediated Signaling Pathway Transport Viral Process Cellular Response To Cytokine Stimulus Ribosomal Small Subunit Export From Nucleus Response To Cytokine Cellular Response To Organic Substance Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Ribosomal Large Subunit Export From Nucleus Cell Communication Ribosomal Subunit Export From Nucleus Response To Organic Substance Cellular Response To Stimulus Apoptotic DNA Fragmentation Apoptotic Nuclear Changes Protein Export From Nucleus Response To Stimulus Positive Regulation Of Cell Cycle Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Nuclear Speck Organization Regulation Of DNA Recombination Ribonucleoprotein Complex Biogenesis Execution Phase Of Apoptosis Synaptic Growth At Neuromuscular Junction Viral Penetration Into Host Nucleus DNA Catabolic Process, Endonucleolytic Regulation Of Cell Cycle	Viral Process RNA Metabolic Process Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Cellular Response To Stress Response To Organic Substance Nitrogen Compound Metabolic Process Gene Expression Nucleotide-excision Repair, DNA Damage Removal Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Process Termination Of RNA Polymerase I Transcription Programmed Cell Death Transcription Elongation From RNA Polymerase I Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter DNA Catabolic Process Osteoblast Differentiation Transcription Initiation From RNA Polymerase I Promoter Cell Death Death 7-methylguanosine MRNA Capping Response To Abiotic Stimulus Transcription From RNA Polymerase I Promoter 7-methylguanosine RNA Capping Positive Regulation Of Metabolic Process Regulation Of Gene Expression Transcription-coupled Nucleotide-excision Repair Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Stimulus Regulation Of Transcription, DNA-templated Positive Regulation Of Viral Transcription Positive Regulation Of Wound Healing Regulation Of Nucleic Acid-templated Transcription Cellular Response To DNA Damage Stimulus Regulation Of RNA Biosynthetic Process Response To Lipid Response To Estrogen Regulation Of Gene Expression, Epigenetic Negative Regulation Of Interleukin-12 Biosynthetic Process Nucleotide-excision Repair, DNA Duplex Unwinding Notochord Cell Development Regulation Of Cell Cycle Process Cellular Macromolecule Catabolic Process Macromolecule Biosynthetic Process
Tagcloud ?		accompany als amyotrophic cytosolic degenerating deleterious deregulation disrupted dominantly drosophila elicited flies hey histopathologic inherited intercellular lifespan microarrays misregulation neurotoxicity notch nucleoporin paradigms paralysis signature spindleb tardbp tdp widespread	alpha4 ataxias capicua desensitize erk ets etv etv1 etv4 etv5 give highlight hmg importin interconnections mechanistic modulating motivating multisite nls p90 pea3 phosphorylations polyoma relieved represses rsk s6 spinocerebellar
Tagcloud (Difference) ?		accompany als amyotrophic cytosolic degenerating deleterious deregulation disrupted dominantly drosophila elicited flies hey histopathologic inherited intercellular lifespan microarrays misregulation neurotoxicity notch nucleoporin paradigms paralysis signature spindleb tardbp tdp widespread	alpha4 ataxias capicua desensitize erk ets etv etv1 etv4 etv5 give highlight hmg importin interconnections mechanistic modulating motivating multisite nls p90 pea3 phosphorylations polyoma relieved represses rsk s6 spinocerebellar
Tagcloud (Intersection) ?