KIR3DL1 and RPS6KB1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		KIR3DL1	RPS6KB1
Gene Name		killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1	ribosomal protein S6 kinase, 70kDa, polypeptide 1
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Cell Surface Cell Junction Neuron Projection Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	HLA-B Specific Inhibitory MHC Class I Receptor Activity	Protein Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Peptide Binding
	Biological Process	Immune Response Signal Transduction Regulation Of Immune Response	G1/S Transition Of Mitotic Cell Cycle Skeletal Muscle Contraction Protein Phosphorylation Apoptotic Process Signal Transduction Germ Cell Development Aging Response To Nutrient Long-term Memory Insulin Receptor Signaling Pathway Response To Heat Response To Wounding Response To Mechanical Stimulus Response To Toxic Substance Response To Glucose Skeletal Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Positive Regulation Of Smooth Muscle Cell Migration Cell Migration TOR Signaling Response To Lipopolysaccharide Response To Testosterone Response To Glucagon Response To Tumor Necrosis Factor Response To Drug Negative Regulation Of Apoptotic Process Response To Leucine Protein Kinase B Signaling Response To Ethanol Positive Regulation Of Translation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Translational Initiation Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Skeletal Muscle Tissue Growth Positive Regulation Of Smooth Muscle Cell Proliferation Response To Glucocorticoid Cellular Response To Growth Factor Stimulus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System	Insulin receptor signalling cascade IRS-mediated signalling mTOR signalling S6K1 signalling S6K1-mediated signalling IRS-related events mTOR signalling mTORC1-mediated signalling IGF1R signaling cascade S6K1-mediated signalling mTORC1-mediated signalling IRS-related events triggered by IGF1R IRS-mediated signalling S6K1 signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PKB-mediated events PKB-mediated events PI3K Cascade PI3K Cascade Signaling by Insulin receptor
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 21833088) Obesity-related traits ( 23251661)
Protein-Protein Interactions		3 interactors: CDK3 HLA-B RPS6KB1	54 interactors: ACTA1 AKT1 APP BTK CDC42 CDK1 CLEC3B COASY CSNK2A1 CSNK2B DPPA4 EEF2K EIF4B EIF4EBP1 EP300 GDI2P1 HTT IRS1 KAT2B KIR3DL1 LYN MAPK1 MAPK3 MAPK8 MAPK9 MAPT MLST8 MTOR MXD1 NCBP1 NEDD4 NEK6 NR1I2 PDK1 PDPK1 PIK3CA PIN1 POLDIP3 PPP1R9A PPP1R9B PPP2CA RAC1 RBX1 RHEB RICTOR RPS6 RPTOR SRC STK11 SYK TERT TRAF4 URI1 XPO1
Entrez ID		3811	6198
HPRD ID		09226	10202
Ensembl ID		ENSG00000167633	ENSG00000108443
Uniprot IDs		P43629 Q15702 Q5UCE2 Q8N6C9	B2R779 B4DLT4 B4DTG1 F6UYM1 P23443 Q7Z721
PDB IDs		3VH8	3A60 3A61 3A62 4L3J 4L3L 4L42 4L43 4L44 4L45 4L46
Enriched GO Terms of Interacting Partners?		G1/S Transition Of Mitotic Cell Cycle G0 To G1 Transition Positive Regulation Of Skeletal Muscle Tissue Growth Protection From Natural Killer Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Skeletal Muscle Atrophy Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Response To Leucine Striated Muscle Atrophy Muscle Atrophy Skeletal Muscle Adaptation Regulation Of Dendritic Cell Differentiation Regulation Of T Cell Anergy Response To Bacterium Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Positive Regulation Of Translational Initiation Antigen Processing And Presentation Of Endogenous Antigen Mitotic Cell Cycle Process Response To Cytokine Response To Other Organism Detection Of Bacterium TOR Signaling Regulation Of Natural Killer Cell Mediated Cytotoxicity Response To Biotic Stimulus Mitotic Cell Cycle Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Skeletal Muscle Tissue Development Skeletal Muscle Contraction Detection Of Biotic Stimulus Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Regulation Of Cell Cycle Response To Testosterone Negative Regulation Of Innate Immune Response Negative Regulation Of Insulin Receptor Signaling Pathway Protein Kinase B Signaling Regulation Of Smooth Muscle Cell Migration Response To Electrical Stimulus Musculoskeletal Movement Cell Cycle Process Long-term Memory Response To Glucagon Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of Insulin Receptor Signaling Pathway Regulation Of T Cell Mediated Cytotoxicity Regulation Of Glucose Import	Cellular Response To Organic Substance Response To Organic Substance Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Insulin Stimulus Response To Insulin Insulin Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Peptide Hormone Stimulus Regulation Of Cellular Protein Metabolic Process Cellular Response To Peptide Cellular Response To Organonitrogen Compound Fc Receptor Signaling Pathway Cellular Response To Hormone Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Hormone Fc-epsilon Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Protein Phosphorylation Response To Peptide Hormone Positive Regulation Of Protein Metabolic Process Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Response To Peptide Regulation Of Signal Transduction Regulation Of Phosphorylation Cellular Response To Stimulus Positive Regulation Of Protein Phosphorylation Response To Organonitrogen Compound Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphorylation Signal Transduction Regulation Of Signaling Innate Immune Response Intracellular Signal Transduction Signaling Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Signal Transduction Cell Communication Immune Response Positive Regulation Of Protein Modification Process Regulation Of Kinase Activity Regulation Of Metabolic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Metabolic Process T Cell Costimulation Response To Growth Factor Neurotrophin TRK Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway
Tagcloud ?		ab adaptor ap clathrin diminish diminished endocytosis endosomes engagement ig inhibitory internalization internalized itim killer kirs leaves maintaining mhc mu2 nk nonengaged prolonging readily recycling surface tyrosines undergoes	70kda ablation amp ampk aortas apoe apolipoprotein arg2 arginase atherogenesis atherosclerosis atherosclerotic autophagy crosstalk h160f impairs interested mtorc1 mtorc2 nonsenescent polypeptide prkaa replicative rictor s6k1 senescent ureahydrolase wk
Tagcloud (Difference) ?		ab adaptor ap clathrin diminish diminished endocytosis endosomes engagement ig inhibitory internalization internalized itim killer kirs leaves maintaining mhc mu2 nk nonengaged prolonging readily recycling surface tyrosines undergoes	70kda ablation amp ampk aortas apoe apolipoprotein arg2 arginase atherogenesis atherosclerosis atherosclerotic autophagy crosstalk h160f impairs interested mtorc1 mtorc2 nonsenescent polypeptide prkaa replicative rictor s6k1 senescent ureahydrolase wk
Tagcloud (Intersection) ?