KIF3C and MCC

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KIF3C	MCC
Description		kinesin family member 3C	MCC regulator of Wnt signaling pathway
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Kinesin Complex Microtubule Cilium Ciliary Tip	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Lamellipodium Cell Projection
	Molecular Function	Nucleotide Binding Cytoskeletal Motor Activity Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATP Hydrolysis Activity	Protein Binding Signaling Receptor Activity
	Biological Process	Microtubule-based Movement	Signal Transduction Negative Regulation Of Epithelial Cell Migration Wnt Signaling Pathway Establishment Of Protein Localization Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		MHC class II antigen presentation Intraflagellar transport COPI-dependent Golgi-to-ER retrograde traffic Kinesins Kinesins
Drugs
Diseases
GWAS		Atrial fibrillation ( 29892015 30061737)	Adult body size ( 32376654) Brain cytoarchitecture ( 20308991) Cerebral amyloid angiopathy ( 25188341) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 31562340) Metabolite levels ( 23823483) Neurofibrillary tangles ( 31497858) Nicotine dependence symptom count ( 25555482) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		5 interacting genes: CDC5L DISC1 KIF3A MCC TFIP11	77 interacting genes: ALDOB ANP32B APP BAAT C8orf33 C8orf48 CBX5 CBX8 CCDC112 CCDC146 CCDC180 CCDC185 CCDC187 CDC14B CDK8 CDKL3 CEP57L1 CEP95 CFAP58 CYLC2 DNAAF4 DYNC1I1 ELOA ERBIN ESRRG FAM161A FGF16 FRAT2 GTF2E2 HEMGN HSD17B3 KAT5 KEAP1 KIF3C KIFC3 LRRC45 MSANTD3 MTNR1A NANS NEK2 NFKBIB NOL12 PCCA PNKP POLL PRPF18 RASAL2 RCOR3 SEC61B SFRP4 SLTM SLU7 SYT17 SYT6 TCEA2 TCEANC TGFB1 THAP7 TRMO TRMT2A TSHZ2 TSTD2 TXLNA UTP14C ZBTB48 ZNF12 ZNF189 ZNF202 ZNF264 ZNF3 ZNF35 ZNF417 ZNF438 ZNF497 ZNF543 ZNF648 ZNF792
Entrez ID		3797	4163
HPRD ID		04164	01157
Ensembl ID		ENSG00000084731	ENSG00000171444
Uniprot IDs		A2RU78 O14782	P23508
PDB IDs		3B6V	6MTU 6MTV
Enriched GO Terms of Interacting Partners?		Kinesin Complex Spliceosomal Complex RNA Splicing, Via Transesterification Reactions WD40-repeat Domain Binding MRNA Splicing, Via Spliceosome Catalytic Step 2 Spliceosome Wnt Signaling Pathway Plus-end-directed Vesicle Transport Along Microtubule Cilium Assembly Plus-end-directed Organelle Transport Along Microtubule Kinesin II Complex Spliceosomal Complex Disassembly Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Protection From Non-homologous End Joining At Telomere U2-type Post-mRNA Release Spliceosomal Complex Radial Glia-guided Pyramidal Neuron Migration Pyramidal Neuron Migration To Cerebral Cortex Cerebral Cortex Radial Glia-guided Migration Central Region Of Growth Cone DNA Replication Factor A Complex RNA Splicing Prp19 Complex Regulation Of Wnt Signaling Pathway Microtubule Microtubule Anchoring At Centrosome Plasma Membrane Bounded Cell Projection Assembly Protein-containing Complex Binding Cell Projection Assembly Microtubule Anchoring At Microtubule Organizing Center Centriole-centriole Cohesion Cilium Organization Telomere Maintenance In Response To DNA Damage Cell Proliferation In Forebrain Negative Regulation Of Epithelial Cell Migration Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain	Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Centrosome
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