KCNQ3 and CHAT

		KCNQ3	CHAT
Description		potassium voltage-gated channel subfamily Q member 3	choline O-acetyltransferase
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GO Annotations	Cellular Component	Mitochondrion Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Membrane Node Of Ranvier Monoatomic Ion Channel Complex Axon Initial Segment Synapse	Nucleus Cytoplasm Cytosol Neuron Projection Synapse
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Protein Binding Calmodulin Binding Voltage-gated Monoatomic Cation Channel Activity	Choline O-acetyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity
	Biological Process	Protein Targeting Protein Import Into Nucleus Monoatomic Ion Transport Potassium Ion Transport Exocytosis Endocytosis Chemical Synaptic Transmission Sensory Perception Of Sound Response To Mechanical Stimulus Gene Expression Response To Auditory Stimulus Protein Transport Neuron Remodeling Neuronal Action Potential Nerve Development Neuron Differentiation Monoatomic Ion Transmembrane Transport Psychomotor Behavior Regulation Of Synaptic Plasticity Neuron Apoptotic Process Establishment Of Localization In Cell Mitochondrial Depolarization Transmembrane Transport Membrane Hyperpolarization Protein-containing Complex Assembly Cellular Response To Calcium Ion Cellular Response To Xenobiotic Stimulus Potassium Ion Transmembrane Transport Apoptosome Assembly Excitatory Chemical Synaptic Transmission Inhibitory Chemical Synaptic Transmission Action Potential Initiation Regulation Of Action Potential Firing Threshold Substantia Propria Of Cornea Development	Phosphatidylcholine Biosynthetic Process Neurotransmitter Transport Neuromuscular Synaptic Transmission Acetylcholine Biosynthetic Process
Pathways		Voltage gated Potassium channels Interaction between L1 and Ankyrins	Synthesis of PC Acetylcholine Neurotransmitter Release Cycle
Drugs		Enflurane Amitriptyline Meclofenamic acid Gabapentin Promethazine Miconazole Ezogabine ICA-105665	Nicotine
Diseases			Congenital myasthenic syndrome
GWAS		Coronary artery calcification ( 23870195) Height ( 28552196) LDL peak particle diameter (total fat intake interaction) ( 26112879) QT interval ( 29213071) Type 2 diabetes ( 31324766)	Glaucoma (primary angle closure) ( 27064256) Interleukin-1-receptor antagonist levels ( 22205395) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Type 2 diabetes nephropathy ( 30566433)
Interacting Genes		6 interacting genes: CALM1 CALM2 CALM3 KCNQ2 KCNQ4 KCNQ5	9 interacting genes: CAMK2A CAMK2G NEDD9 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCZ
Entrez ID		3786	1103
HPRD ID		09077	07510
Ensembl ID		ENSG00000184156	ENSG00000070748
Uniprot IDs		E7ET42 O43525	P28329 Q6LEN5 Q6LEN6
PDB IDs		5J03	2FY2 2FY3 2FY4 2FY5 7AMD
Enriched GO Terms of Interacting Partners?		Voltage-gated Potassium Channel Complex Calyx Of Held Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Titin Binding Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Protein Phosphatase Activator Activity Catalytic Complex Negative Regulation Of Transporter Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Calcium Channel Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Transmembrane Transport Calcineurin-mediated Signaling Presynaptic Cytosol Myelin Sheath Response To Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Negative Regulation Of Calcium Ion Transmembrane Transport Spindle Microtubule Presynaptic Endocytosis Substantia Nigra Development Calcium Channel Regulator Activity Sperm Midpiece Negative Regulation Of Calcium Ion Transport G2/M Transition Of Mitotic Cell Cycle Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Voltage-gated Potassium Channel Activity Long-term Synaptic Potentiation Sarcomere Cell Cycle G2/M Phase Transition Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Neural Nucleus Development Positive Regulation Of Sequestering Of Calcium Ion Negative Regulation Of Cation Transmembrane Transport Protein Serine/threonine Kinase Activator Activity Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Voltage-gated Calcium Channel Activity Potassium Channel Activity Calcium-dependent Protein Binding Regulation Of Cardiac Muscle Contraction Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity	Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Activity Kinase Activity Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Signaling Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synaptic Transmission Protein Phosphorylation Long-term Synaptic Potentiation Phosphorylation Regulation Of Synaptic Plasticity ATP Binding Regulation Of Protein Localization Histone H3T6 Kinase Activity Nucleotide Binding Regulation Of Biological Quality Transferase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Positive Regulation Of Protein Localization Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Cellular Response To Insulin Stimulus Calcium- And Calmodulin-dependent Protein Kinase Complex Regulation Of Cell Communication Regulation Of Signaling Regulation Of Transport Positive Regulation Of Immune System Process Regulation Of Secretion By Cell Positive Regulation Of Protein Transport Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cellular Response To Insulin Stimulus Regulation Of Secretion Response To Hormone Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Neurotransmitter Secretion Positive Regulation Of Insulin Secretion Mitotic Nuclear Membrane Disassembly Response To Peptide Hormone Positive Regulation Of Establishment Of Protein Localization Insulin Receptor Substrate Binding Positive Regulation Of Peptide Hormone Secretion Nuclear Membrane Disassembly Positive Regulation Of Peptide Secretion Membrane Disassembly Phosphate-containing Compound Metabolic Process Regulation Of Protein Localization To Plasma Membrane Response To Morphine
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