KCNQ3 and KCNQ4

Number of citations of the paper that reports this interaction (PubMedID 10025409)
0

Data Source:
HPRD (in vitro)

		KCNQ3	KCNQ4
Description		potassium voltage-gated channel subfamily Q member 3	potassium voltage-gated channel subfamily Q member 4
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GO Annotations	Cellular Component	Mitochondrion Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Membrane Node Of Ranvier Monoatomic Ion Channel Complex Axon Initial Segment Synapse	Plasma Membrane Voltage-gated Potassium Channel Complex Basal Plasma Membrane Membrane Monoatomic Ion Channel Complex
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Protein Binding Calmodulin Binding Voltage-gated Monoatomic Cation Channel Activity	Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Protein Binding
	Biological Process	Protein Targeting Protein Import Into Nucleus Monoatomic Ion Transport Potassium Ion Transport Exocytosis Endocytosis Chemical Synaptic Transmission Sensory Perception Of Sound Response To Mechanical Stimulus Gene Expression Response To Auditory Stimulus Protein Transport Neuron Remodeling Neuronal Action Potential Nerve Development Neuron Differentiation Monoatomic Ion Transmembrane Transport Psychomotor Behavior Regulation Of Synaptic Plasticity Neuron Apoptotic Process Establishment Of Localization In Cell Mitochondrial Depolarization Transmembrane Transport Membrane Hyperpolarization Protein-containing Complex Assembly Cellular Response To Calcium Ion Cellular Response To Xenobiotic Stimulus Potassium Ion Transmembrane Transport Apoptosome Assembly Excitatory Chemical Synaptic Transmission Inhibitory Chemical Synaptic Transmission Action Potential Initiation Regulation Of Action Potential Firing Threshold Substantia Propria Of Cornea Development	Monoatomic Ion Transport Potassium Ion Transport Sensory Perception Of Sound Monoatomic Ion Transmembrane Transport Inner Ear Morphogenesis Transmembrane Transport Potassium Ion Transmembrane Transport
Pathways		Voltage gated Potassium channels Interaction between L1 and Ankyrins	Voltage gated Potassium channels Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs		Enflurane Amitriptyline Meclofenamic acid Gabapentin Promethazine Miconazole Ezogabine ICA-105665	Enflurane Promethazine Miconazole Ezogabine ICA-105665
Diseases			Deafness, autosomal dominant
GWAS		Coronary artery calcification ( 23870195) Height ( 28552196) LDL peak particle diameter (total fat intake interaction) ( 26112879) QT interval ( 29213071) Type 2 diabetes ( 31324766)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		6 interacting genes: CALM1 CALM2 CALM3 KCNQ2 KCNQ4 KCNQ5	1 interacting genes: KCNQ3
Entrez ID		3786	9132
HPRD ID		09077	04641
Ensembl ID		ENSG00000184156	ENSG00000117013
Uniprot IDs		E7ET42 O43525	B3KQH8 P56696
PDB IDs		5J03	2OVC 4GOW 6N5W 7BYL 7BYM 7BYN 7VNP 7VNQ 7VNR
Enriched GO Terms of Interacting Partners?		Voltage-gated Potassium Channel Complex Calyx Of Held Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Titin Binding Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Protein Phosphatase Activator Activity Catalytic Complex Negative Regulation Of Transporter Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Calcium Channel Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Transmembrane Transport Calcineurin-mediated Signaling Presynaptic Cytosol Myelin Sheath Response To Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Negative Regulation Of Calcium Ion Transmembrane Transport Spindle Microtubule Presynaptic Endocytosis Substantia Nigra Development Calcium Channel Regulator Activity Sperm Midpiece Negative Regulation Of Calcium Ion Transport G2/M Transition Of Mitotic Cell Cycle Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Voltage-gated Potassium Channel Activity Long-term Synaptic Potentiation Sarcomere Cell Cycle G2/M Phase Transition Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Neural Nucleus Development Positive Regulation Of Sequestering Of Calcium Ion Negative Regulation Of Cation Transmembrane Transport Protein Serine/threonine Kinase Activator Activity Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Voltage-gated Calcium Channel Activity Potassium Channel Activity Calcium-dependent Protein Binding Regulation Of Cardiac Muscle Contraction Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity	Regulation Of Action Potential Firing Threshold Inhibitory Chemical Synaptic Transmission Apoptosome Assembly Substantia Propria Of Cornea Development Action Potential Initiation N-acetyllactosaminide Alpha-2,3-sialyltransferase Activity Psychomotor Behavior Ganglioside Biosynthetic Process Via Lactosylceramide Mitochondrial Depolarization Membrane Hyperpolarization Beta-galactoside (CMP) Alpha-2,3-sialyltransferase Activity Voltage-gated Monoatomic Cation Channel Activity Excitatory Chemical Synaptic Transmission Voltage-gated Monoatomic Ion Channel Activity Ganglioside Biosynthetic Process Neuron Remodeling Keratan Sulfate Proteoglycan Biosynthetic Process Keratan Sulfate Proteoglycan Metabolic Process Sialyltransferase Activity Node Of Ranvier Response To Auditory Stimulus Axon Initial Segment Ganglioside Metabolic Process Oligosaccharide Biosynthetic Process Motor Behavior Neuronal Action Potential Neuron Maturation Glycosphingolipid Biosynthetic Process Viral Protein Processing Protein O-linked Glycosylation Via N-acetyl-galactosamine Nerve Development Voltage-gated Potassium Channel Activity Membrane Depolarization Ceramide Biosynthetic Process Glycosphingolipid Metabolic Process Oligosaccharide Metabolic Process Macromolecule Biosynthetic Process Regulation Of Action Potential Proteoglycan Biosynthetic Process Cellular Response To Xenobiotic Stimulus Glycolipid Biosynthetic Process Golgi Cisterna Membrane Regulation Of Mitochondrial Membrane Potential Potassium Channel Activity Voltage-gated Potassium Channel Complex Cellular Response To Calcium Ion Proteoglycan Metabolic Process Glycolipid Metabolic Process Ceramide Metabolic Process Sphingolipid Biosynthetic Process
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