ICMT and RNF19B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ICMT	RNF19B
Description		isoprenylcysteine carboxyl methyltransferase	ring finger protein 19B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Ubiquitin Ligase Complex Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Cytolytic Granule
	Molecular Function	Protein C-terminal Carboxyl O-methyltransferase Activity Protein C-terminal S-isoprenylcysteine Carboxyl O-methyltransferase Activity Protein Binding Methyltransferase Activity Transferase Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Conjugating Enzyme Binding Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	C-terminal Protein Methylation Protein Targeting To Membrane Nuclear Envelope Organization Methylation Protein Modification Process S-adenosylhomocysteine Metabolic Process S-adenosylmethioninamine Metabolic Process Protein Maturation	Adaptive Immune Response Immune System Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Natural Killer Cell Mediated Cytotoxicity Protein Autoubiquitination
Pathways		Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation RAS processing	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Resting heart rate ( 27798624 28270201)	Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269)
Interacting Genes		12 interacting genes: AQP6 ARL13B HRAS JAGN1 KCNJ6 MUC1 PDZK1IP1 RAC1 RAC2 RHOA RNF19B TRIM32	30 interacting genes: APOL3 ASGR1 CDIPT CLEC1A DHODH FDPS GIMAP5 GOSR2 ICMT MEST MS4A1 NIPAL4 PPP1CC RAP1GDS1 SACM1L SEC22A SEC23A SELENOK SLC30A3 SLC61A1 TAP1 TMEM100 TMEM120B TMEM208 TMEM31 TNF TSPAN2 UBE2D2 UBE2D3 UBE2L3
Entrez ID		23463	127544
HPRD ID		09321	13725
Ensembl ID		ENSG00000116237	ENSG00000116514
Uniprot IDs		B3KS61 O60725 Q7Z750	Q6ZMZ0
PDB IDs
Enriched GO Terms of Interacting Partners?		Telencephalon Cell Migration Forebrain Cell Migration GTPase Activity GTP Binding Erythrocyte Enucleation Positive Regulation Of Cellular Component Biogenesis G Protein Activity Regulation Of Cell Projection Assembly Small GTPase-mediated Signal Transduction Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Endoplasmic Reticulum Membrane Positive Regulation Of Locomotion Positive Regulation Of Ruffle Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Chemotaxis Regulation Of Hydrogen Peroxide Metabolic Process NADPH Oxidase Complex Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Locomotion Regulation Of Respiratory Burst Actin Cytoskeleton Organization Cell Projection Assembly Respiratory Burst Regulation Of Actin Filament-based Process Regulation Of Reactive Oxygen Species Metabolic Process Superoxide Anion Generation Response To External Biotic Stimulus Positive Regulation Of Neutrophil Chemotaxis Myosin Binding Actin Filament-based Process Positive Regulation Of Leukocyte Migration Positive Regulation Of Granulocyte Chemotaxis Positive Regulation Of Lamellipodium Assembly Establishment Or Maintenance Of Cell Polarity Cerebral Cortex Cell Migration Regulation Of Ruffle Assembly Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Neutrophil Migration Regulation Of Neutrophil Chemotaxis Wnt Signaling Pathway, Planar Cell Polarity Pathway Tissue Homeostasis Anatomical Structure Homeostasis Positive Regulation Of Lamellipodium Organization Cell Morphogenesis Lamellipodium Regulation Of Neuron Differentiation Membrane	Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Ubiquitin Conjugating Enzyme Activity
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