ICMT and JAGN1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ICMT	JAGN1
Description		isoprenylcysteine carboxyl methyltransferase	jagunal vesicle mediated transporter 1
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein C-terminal Carboxyl O-methyltransferase Activity Protein C-terminal S-isoprenylcysteine Carboxyl O-methyltransferase Activity Protein Binding Methyltransferase Activity Transferase Activity	Protein Binding
	Biological Process	C-terminal Protein Methylation Protein Targeting To Membrane Nuclear Envelope Organization Methylation Protein Modification Process S-adenosylhomocysteine Metabolic Process S-adenosylmethioninamine Metabolic Process Protein Maturation	Immune System Process Neutrophil Mediated Immunity Exocytosis Endoplasmic Reticulum Organization Response To Glucose Protein Transport Vesicle-mediated Transport Insulin Secretion Neutrophil Differentiation Response To Endoplasmic Reticulum Stress Granulocyte Colony-stimulating Factor Signaling Pathway Defense Response To Fungus Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Insulin Metabolic Process Neutrophil Migration
Pathways		Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation RAS processing
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Resting heart rate ( 27798624 28270201)
Interacting Genes		12 interacting genes: AQP6 ARL13B HRAS JAGN1 KCNJ6 MUC1 PDZK1IP1 RAC1 RAC2 RHOA RNF19B TRIM32	128 interacting genes: AGPAT4 APP AQP6 ARL13B ARLN BCL2L13 BET1 BMP10 BNIP1 BNIP3 BSND BTNL9 CALHM6 CCL4L2 CD79A CDIPT CERS4 CGRRF1 CLDN7 CLEC12B CLEC4D CLEC7A CMTM5 COX20 CREB3L1 CYBC1 CYP4F2 DNAJC30 EBP EDA2R EHHADH ELOVL4 ERG28 ERGIC3 F11R FAM177A1 FAM209A FCGR1A FCRL2 FCRL4 FDFT1 FIS1 FKBP8 FNDC9 FRMD3 FXYD6 GIMAP1 GIMAP5 GJB5 GOLM1 GOSR2 GP2 GPR152 GPR37L1 HMOX1 HSD17B13 HTATIP2 ICMT IER3IP1 IFNGR2 IL3RA KASH5 KCNA1 KIR2DL3 KIR3DL3 LEMD1 LHFPL5 LMNA LPAR3 MFF MRM3 MTIF3 NINJ2 NRG1 OTULINL PDZK1IP1 PLP1 PLPP2 PSCA RETREG3 RTP2 SACM1L SAR1A SCD SEC22B SERP1 SLAMF6 SLC10A6 SLC16A2 SLC23A2 SLC34A2 SMAGP SMIM1 SMIM19 SSMEM1 STOML3 STX1A STX3 STX5 STX7 STX8 TECR TIMM23 TMEM100 TMEM106C TMEM120B TMEM128 TMEM14B TMEM207 TMEM237 TMEM242 TMEM243 TMEM52B TMEM65 TMIE TNFSF14 TREX1 TSNARE1 UBE2J1 USE1 VAMP2 VAMP5 VAPA VAPB VKORC1 VMA12 VSIG4 VTI1B
Entrez ID		23463	84522
HPRD ID		09321	13749
Ensembl ID		ENSG00000116237	ENSG00000171135
Uniprot IDs		B3KS61 O60725 Q7Z750	Q8N5M9
PDB IDs			6WVD
Enriched GO Terms of Interacting Partners?		Telencephalon Cell Migration Forebrain Cell Migration GTPase Activity GTP Binding Erythrocyte Enucleation Positive Regulation Of Cellular Component Biogenesis G Protein Activity Regulation Of Cell Projection Assembly Small GTPase-mediated Signal Transduction Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Endoplasmic Reticulum Membrane Positive Regulation Of Locomotion Positive Regulation Of Ruffle Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Chemotaxis Regulation Of Hydrogen Peroxide Metabolic Process NADPH Oxidase Complex Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Locomotion Regulation Of Respiratory Burst Actin Cytoskeleton Organization Cell Projection Assembly Respiratory Burst Regulation Of Actin Filament-based Process Regulation Of Reactive Oxygen Species Metabolic Process Superoxide Anion Generation Response To External Biotic Stimulus Positive Regulation Of Neutrophil Chemotaxis Myosin Binding Actin Filament-based Process Positive Regulation Of Leukocyte Migration Positive Regulation Of Granulocyte Chemotaxis Positive Regulation Of Lamellipodium Assembly Establishment Or Maintenance Of Cell Polarity Cerebral Cortex Cell Migration Regulation Of Ruffle Assembly Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Neutrophil Migration Regulation Of Neutrophil Chemotaxis Wnt Signaling Pathway, Planar Cell Polarity Pathway Tissue Homeostasis Anatomical Structure Homeostasis Positive Regulation Of Lamellipodium Organization Cell Morphogenesis Lamellipodium Regulation Of Neuron Differentiation Membrane	Membrane Endoplasmic Reticulum Membrane SNAP Receptor Activity Endoplasmic Reticulum SNARE Complex Membrane Fusion Organelle Membrane Fusion SNARE Binding Protein Binding Vesicle Fusion Organelle Fusion Organelle Localization By Membrane Tethering Membrane Organization Golgi Vesicle Transport Membrane Docking Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endomembrane System Chloride Channel Inhibitor Activity Vesicle Docking Vesicle Organization Vesicle-mediated Transport Endoplasmic Reticulum Organization Plasma Membrane Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane External Side Of Plasma Membrane Establishment Of Protein Localization Cellular Localization Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex FFAT Motif Binding Lipid Biosynthetic Process Zymogen Granule Membrane Endoplasmic Reticulum-autophagosome Adaptor Activity Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Vesicle Positive Regulation Of Mitochondrial Fission Synaptic Vesicle COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Organelle Localization
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