AGRN and DAG1

Number of citations of the paper that reports this interaction (PMID 8205617)
94

Data Source:
BioGRID (far western blotting)

		AGRN	DAG1
Gene Name		agrin	dystroglycan 1 (dystrophin-associated glycoprotein 1)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Basal Lamina Extracellular Space Cytoplasm Golgi Lumen Plasma Membrane Cell Surface Integral Component Of Membrane Cell Junction Extracellular Matrix Lysosomal Lumen Synapse Extracellular Vesicular Exosome	Extracellular Region Basement Membrane Extracellular Space Nucleoplasm Cytoplasm Cytoskeleton Plasma Membrane Cell-cell Adherens Junction Focal Adhesion Cell Outer Membrane Dystrophin-associated Glycoprotein Complex Dystroglycan Complex Integral Component Of Membrane Basolateral Plasma Membrane Lamellipodium Filopodium Node Of Ranvier Sarcolemma Costamere Membrane Raft Postsynaptic Membrane Extracellular Vesicular Exosome Contractile Ring
	Molecular Function	Dystroglycan Binding Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Acetylcholine Receptor Regulator Activity Sialic Acid Binding Chondroitin Sulfate Binding Laminin Binding Heparan Sulfate Proteoglycan Binding	Virus Receptor Activity Dystroglycan Binding Actin Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Tubulin Binding Vinculin Binding Protein Complex Binding SH2 Domain Binding Laminin-1 Binding Alpha-actinin Binding
	Biological Process	Retinoid Metabolic Process Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Plasma Membrane Organization Signal Transduction G-protein Coupled Acetylcholine Receptor Signaling Pathway Axon Guidance Neuromuscular Junction Development Phototransduction, Visible Light Pathogenesis Regulation Of Receptor Activity Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Positive Regulation Of Rho GTPase Activity Receptor Clustering Positive Regulation Of Neuron Apoptotic Process Small Molecule Metabolic Process Clustering Of Voltage-gated Sodium Channels Neurotransmitter Receptor Metabolic Process Positive Regulation Of Synaptic Growth At Neuromuscular Junction Positive Regulation Of Transcription From RNA Polymerase II Promoter Synapse Organization Positive Regulation Of Filopodium Assembly	Morphogenesis Of An Epithelial Sheet Membrane Protein Ectodomain Proteolysis NLS-bearing Protein Import Into Nucleus Cytoskeletal Anchoring At Plasma Membrane Response To Virus Calcium-dependent Cell-matrix Adhesion Modulation By Virus Of Host Morphology Or Physiology Nerve Maturation Myelination In Peripheral Nervous System Extracellular Matrix Organization Negative Regulation Of Cell Migration Microtubule Anchoring Negative Regulation Of MAPK Cascade Response To Peptide Hormone Negative Regulation Of Protein Kinase B Signaling Epithelial Tube Branching Involved In Lung Morphogenesis Branching Involved In Salivary Gland Morphogenesis Commissural Neuron Axon Guidance Basement Membrane Organization
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Axon guidance Defective B4GALT7 causes EDS, progeroid type Heparan sulfate/heparin (HS-GAG) metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora ECM proteoglycans Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis NCAM signaling for neurite out-growth MPS IIIC - Sanfilippo syndrome C Retinoid metabolism and transport Diseases associated with glycosaminoglycan metabolism NCAM1 interactions Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Non-integrin membrane-ECM interactions Defective EXT1 causes exostoses 1, TRPS2 and CHDS Diseases associated with visual transduction MPS IV - Morquio syndrome A Visual phototransduction MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS Integrin cell surface interactions MPS VII - Sly syndrome Metabolism of carbohydrates HS-GAG biosynthesis HS-GAG degradation MPS VI - Maroteaux-Lamy syndrome	ECM proteoglycans Integrin cell surface interactions Non-integrin membrane-ECM interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: ATN1 ATXN7 CACNA1A DAG1 GFI1B	25 interactors: AGR2 AGR3 AGRN BGN CAV1 CAV3 DMD DRP2 FYN GRB2 ITGB1 LAMA1 LAMA2 LAMA5 MAGI1 MAP2 NCK1 RAPSN SHC1 SRC TLN1 TUBA1A UTRN WWP1 WWP2
Entrez ID		375790	1605
HPRD ID		10550	00546
Ensembl ID		ENSG00000188157	ENSG00000173402
Uniprot IDs		O00468	Q14118
PDB IDs			1EG4
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Metabolic Process Cerebellar Molecular Layer Development Nerve Maturation Calcium-dependent Cell-matrix Adhesion Vestibular Nucleus Development Cerebellum Maturation Musculoskeletal Movement, Spinal Reflex Action Gamma-aminobutyric Acid Secretion Regulation Of Acetylcholine Secretion, Neurotransmission Rhythmic Synaptic Transmission Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Calcium Ion-dependent Exocytosis Of Neurotransmitter Cellular Chloride Ion Homeostasis Commissural Neuron Axon Guidance Gamma-aminobutyric Acid Transport Chloride Ion Homeostasis Negative Regulation Of Hormone Biosynthetic Process Cytoskeletal Anchoring At Plasma Membrane Pons Development Maintenance Of Cell Polarity Negative Regulation Of Phosphorylation Toxin Metabolic Process Basement Membrane Organization Cerebellar Purkinje Cell Differentiation Regulation Of Metabolic Process Microtubule Cytoskeleton Organization Cerebellar Purkinje Cell Layer Morphogenesis Histone Deubiquitination Membrane Protein Ectodomain Proteolysis Regulation Of Transcription From RNA Polymerase II Promoter System Development NLS-bearing Protein Import Into Nucleus Reflex Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Behavioral Response To Pain Modulation By Virus Of Host Morphology Or Physiology Regulation Of Histone H3-K4 Methylation Neuromuscular Synaptic Transmission Branching Involved In Salivary Gland Morphogenesis Regulation Of Hormone Biosynthetic Process Cell Morphogenesis Involved In Neuron Differentiation Cerebellar Cortex Formation Neurotransmitter Metabolic Process Chromatin Modification Gamma-aminobutyric Acid Signaling Pathway Cell Differentiation In Hindbrain Multicellular Organismal Development Neuron Projection Morphogenesis Calcium Ion Import	Locomotion Regulation Of Cell Adhesion Cell Projection Morphogenesis Cell Part Morphogenesis Cell Morphogenesis Involved In Differentiation Axonogenesis Axon Development Axon Guidance Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis System Development Neuron Projection Morphogenesis Cell Projection Organization Movement Of Cell Or Subcellular Component Anatomical Structure Morphogenesis Multicellular Organismal Development Positive Regulation Of Cell Adhesion Neuron Projection Development Anatomical Structure Development Cell Development Chemotaxis Negative Regulation Of Peptidyl-serine Phosphorylation Neuron Development Receptor Metabolic Process Developmental Process Extracellular Matrix Organization Extracellular Structure Organization Neuron Differentiation Regulation Of Body Fluid Levels Nervous System Development Leukocyte Migration Wound Healing Cell Adhesion Cell Differentiation Generation Of Neurons Blood Coagulation Hemostasis Neurogenesis Regulation Of Phosphorylation Regulation Of Ion Transmembrane Transporter Activity Response To Wounding Muscle Organ Development Regulation Of Transmembrane Transporter Activity Negative Regulation Of Anoikis Muscle Structure Development Regulation Of Sodium Ion Transport Regulation Of Protein Phosphorylation Regulation Of Anoikis Regulation Of Phosphorus Metabolic Process Cytoskeleton Organization
Tagcloud ?			branches compensates dag1gai dag1rga28 della dof dormancy embryo factor3 ga ga1 gai germination germination1 insensitive lethal master overlapping phytocrome pil5 repressor rga rga28 seed seeds severely surprisingly t6 unexpected
Tagcloud (Difference) ?			branches compensates dag1gai dag1rga28 della dof dormancy embryo factor3 ga ga1 gai germination germination1 insensitive lethal master overlapping phytocrome pil5 repressor rga rga28 seed seeds severely surprisingly t6 unexpected
Tagcloud (Intersection) ?