AGRN

Description		agrin
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GO Annotations	Cellular Component	Extracellular Region Basement Membrane Golgi Lumen Plasma Membrane Membrane Extracellular Matrix Lysosomal Lumen Synapse Extracellular Exosome
	Molecular Function	Dystroglycan Binding Structural Constituent Of Cytoskeleton Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Sialic Acid Binding Chondroitin Sulfate Binding Laminin Binding Heparan Sulfate Proteoglycan Binding Metal Ion Binding
	Biological Process	Cytoskeleton Organization Signal Transduction G Protein-coupled Acetylcholine Receptor Signaling Pathway Nervous System Development Neuromuscular Junction Development Regulation Of Synaptic Assembly At Neuromuscular Junction Cell Differentiation Receptor Clustering Positive Regulation Of GTPase Activity Clustering Of Voltage-gated Sodium Channels Positive Regulation Of Synaptic Assembly At Neuromuscular Junction Positive Regulation Of Transcription By RNA Polymerase II Synapse Organization Positive Regulation Of Filopodium Assembly Membrane Organization Synaptic Signaling
Pathways		Glycosaminoglycan-protein linkage region biosynthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Integrin cell surface interactions Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS NCAM1 interactions Defective B3GALT6 causes EDSP2 and SEMDJL1 Attachment and Entry Attachment and Entry Retinoid metabolism and transport Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions Formation of the dystrophin-glycoprotein complex (DGC)
Drugs
Diseases		Congenital myasthenic syndrome
GWAS
Interacting Genes		11 interacting genes: ATN1 ATXN7 BOLL CACNA1A DAG1 GFI1B HOXA1 MAGED1 NUFIP2 TEPSIN UBC
Entrez ID		375790
HPRD ID		10550
Ensembl ID		ENSG00000188157
Uniprot IDs		O00468
PDB IDs		8S9P
Enriched GO Terms of Interacting Partners?		Nuclear Matrix
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