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AGRN
Gene Name
agrin
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Extracellular Region
Basal Lamina
Extracellular Space
Cytoplasm
Golgi Lumen
Plasma Membrane
Cell Surface
Integral Component Of Membrane
Cell Junction
Extracellular Matrix
Lysosomal Lumen
Synapse
Extracellular Vesicular Exosome
Molecular Function
Dystroglycan Binding
Structural Constituent Of Cytoskeleton
Calcium Ion Binding
Protein Binding
Acetylcholine Receptor Regulator Activity
Sialic Acid Binding
Chondroitin Sulfate Binding
Laminin Binding
Heparan Sulfate Proteoglycan Binding
Biological Process
Retinoid Metabolic Process
Carbohydrate Metabolic Process
Glycosaminoglycan Biosynthetic Process
Glycosaminoglycan Catabolic Process
Plasma Membrane Organization
Signal Transduction
G-protein Coupled Acetylcholine Receptor Signaling Pathway
Axon Guidance
Neuromuscular Junction Development
Phototransduction, Visible Light
Pathogenesis
Regulation Of Receptor Activity
Extracellular Matrix Organization
Glycosaminoglycan Metabolic Process
Chondroitin Sulfate Metabolic Process
Positive Regulation Of Rho GTPase Activity
Receptor Clustering
Positive Regulation Of Neuron Apoptotic Process
Small Molecule Metabolic Process
Clustering Of Voltage-gated Sodium Channels
Neurotransmitter Receptor Metabolic Process
Positive Regulation Of Synaptic Growth At Neuromuscular Junction
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Synapse Organization
Positive Regulation Of Filopodium Assembly
Pathways
MPS IIIB - Sanfilippo syndrome B
Diseases of glycosylation
Axon guidance
Defective B4GALT7 causes EDS, progeroid type
Heparan sulfate/heparin (HS-GAG) metabolism
MPS I - Hurler syndrome
MPS IX - Natowicz syndrome
Chondroitin sulfate/dermatan sulfate metabolism
Defective SLC26A2 causes chondrodysplasias
Glycosaminoglycan metabolism
Defective CHST14 causes EDS, musculocontractural type
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Defective PAPSS2 causes SEMD-PA
MPS IIIA - Sanfilippo syndrome A
Myoclonic epilepsy of Lafora
ECM proteoglycans
Defective CHST6 causes MCDC1
Glycogen storage diseases
MPS IIID - Sanfilippo syndrome D
A tetrasaccharide linker sequence is required for GAG synthesis
NCAM signaling for neurite out-growth
MPS IIIC - Sanfilippo syndrome C
Retinoid metabolism and transport
Diseases associated with glycosaminoglycan metabolism
NCAM1 interactions
Mucopolysaccharidoses
Defective EXT2 causes exostoses 2
MPS II - Hunter syndrome
Defective B3GAT3 causes JDSSDHD
Defective CHST3 causes SEDCJD
Non-integrin membrane-ECM interactions
Defective EXT1 causes exostoses 1, TRPS2 and CHDS
Diseases associated with visual transduction
MPS IV - Morquio syndrome A
Visual phototransduction
MPS IV - Morquio syndrome B
Defective CHSY1 causes TPBS
Integrin cell surface interactions
MPS VII - Sly syndrome
Metabolism of carbohydrates
HS-GAG biosynthesis
HS-GAG degradation
MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS
Protein-protein Interactions
5 interactors:
ATN1
ATXN7
CACNA1A
DAG1
GFI1B
Entrez ID
375790
HPRD ID
10550
Ensembl ID
ENSG00000188157
Uniprot IDs
O00468
PDB IDs
Enriched GO Terms of Interacting Partners
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Negative Regulation Of Cellular Metabolic Process
Cerebellar Molecular Layer Development
Nerve Maturation
Calcium-dependent Cell-matrix Adhesion
Vestibular Nucleus Development
Cerebellum Maturation
Musculoskeletal Movement, Spinal Reflex Action
Gamma-aminobutyric Acid Secretion
Regulation Of Acetylcholine Secretion, Neurotransmission
Rhythmic Synaptic Transmission
Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Negative Regulation Of Biosynthetic Process
Calcium Ion-dependent Exocytosis Of Neurotransmitter
Cellular Chloride Ion Homeostasis
Commissural Neuron Axon Guidance
Gamma-aminobutyric Acid Transport
Chloride Ion Homeostasis
Negative Regulation Of Hormone Biosynthetic Process
Cytoskeletal Anchoring At Plasma Membrane
Pons Development
Maintenance Of Cell Polarity
Negative Regulation Of Phosphorylation
Toxin Metabolic Process
Basement Membrane Organization
Cerebellar Purkinje Cell Differentiation
Regulation Of Metabolic Process
Microtubule Cytoskeleton Organization
Cerebellar Purkinje Cell Layer Morphogenesis
Histone Deubiquitination
Membrane Protein Ectodomain Proteolysis
Regulation Of Transcription From RNA Polymerase II Promoter
System Development
NLS-bearing Protein Import Into Nucleus
Reflex
Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Behavioral Response To Pain
Modulation By Virus Of Host Morphology Or Physiology
Regulation Of Histone H3-K4 Methylation
Neuromuscular Synaptic Transmission
Branching Involved In Salivary Gland Morphogenesis
Regulation Of Hormone Biosynthetic Process
Cell Morphogenesis Involved In Neuron Differentiation
Cerebellar Cortex Formation
Neurotransmitter Metabolic Process
Chromatin Modification
Gamma-aminobutyric Acid Signaling Pathway
Cell Differentiation In Hindbrain
Multicellular Organismal Development
Neuron Projection Morphogenesis
Calcium Ion Import
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