AGRN and ATXN7

Number of citations of the paper that reports this interaction (PMID 21078624)
14

Data Source:
BioGRID (two hybrid)

		AGRN	ATXN7
Gene Name		agrin	ataxin 7
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Basal Lamina Extracellular Space Cytoplasm Golgi Lumen Plasma Membrane Cell Surface Integral Component Of Membrane Cell Junction Extracellular Matrix Lysosomal Lumen Synapse Extracellular Vesicular Exosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Microtubule Cytoskeleton Nuclear Matrix
	Molecular Function	Dystroglycan Binding Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Acetylcholine Receptor Regulator Activity Sialic Acid Binding Chondroitin Sulfate Binding Laminin Binding Heparan Sulfate Proteoglycan Binding	Chromatin Binding Protein Binding
	Biological Process	Retinoid Metabolic Process Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Plasma Membrane Organization Signal Transduction G-protein Coupled Acetylcholine Receptor Signaling Pathway Axon Guidance Neuromuscular Junction Development Phototransduction, Visible Light Pathogenesis Regulation Of Receptor Activity Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Positive Regulation Of Rho GTPase Activity Receptor Clustering Positive Regulation Of Neuron Apoptotic Process Small Molecule Metabolic Process Clustering Of Voltage-gated Sodium Channels Neurotransmitter Receptor Metabolic Process Positive Regulation Of Synaptic Growth At Neuromuscular Junction Positive Regulation Of Transcription From RNA Polymerase II Promoter Synapse Organization Positive Regulation Of Filopodium Assembly	Microtubule Cytoskeleton Organization Chromatin Organization Transcription, DNA-templated Nucleus Organization Visual Perception Histone Deubiquitination Negative Regulation Of Phosphorylation Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Axon guidance Defective B4GALT7 causes EDS, progeroid type Heparan sulfate/heparin (HS-GAG) metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora ECM proteoglycans Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis NCAM signaling for neurite out-growth MPS IIIC - Sanfilippo syndrome C Retinoid metabolism and transport Diseases associated with glycosaminoglycan metabolism NCAM1 interactions Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Non-integrin membrane-ECM interactions Defective EXT1 causes exostoses 1, TRPS2 and CHDS Diseases associated with visual transduction MPS IV - Morquio syndrome A Visual phototransduction MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS Integrin cell surface interactions MPS VII - Sly syndrome Metabolism of carbohydrates HS-GAG biosynthesis HS-GAG degradation MPS VI - Maroteaux-Lamy syndrome	Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: ATN1 ATXN7 CACNA1A DAG1 GFI1B	59 interactors: ACTN1 ACTN2 ACTN4 ADAM33 AGRN CARD10 CEP70 CEP72 COG6 CRIM1 CRX EFEMP1 EFEMP2 FBN1 FN1 GOLGA2 GOLGA3 GPRASP1 GRN HIST1H3A JAG2 KALRN KAT2A LAMB1 LAMB2 LRSAM1 LTBP4 MATN2 MEGF6 MPRIP NELL1 NELL2 NOC2L NUP62 PICK1 PNMA1 PPP1R12C PSMC1 RABEP1 RAD23A RNF31 SIAH1 SNX1 SPRY1 SSFA2 SUMO1 SUMO2 TAF10 THY1 TP53BP2 TRAF2 TRIM23 TRIM27 TRIM54 TRRAP TXNDC11 UBQLN2 VCP VWF
Entrez ID		375790	6314
HPRD ID		10550	06365
Ensembl ID		ENSG00000188157	ENSG00000163635
Uniprot IDs		O00468	O15265 Q9UPD8
PDB IDs			2KKR
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Metabolic Process Cerebellar Molecular Layer Development Nerve Maturation Calcium-dependent Cell-matrix Adhesion Vestibular Nucleus Development Cerebellum Maturation Musculoskeletal Movement, Spinal Reflex Action Gamma-aminobutyric Acid Secretion Regulation Of Acetylcholine Secretion, Neurotransmission Rhythmic Synaptic Transmission Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Calcium Ion-dependent Exocytosis Of Neurotransmitter Cellular Chloride Ion Homeostasis Commissural Neuron Axon Guidance Gamma-aminobutyric Acid Transport Chloride Ion Homeostasis Negative Regulation Of Hormone Biosynthetic Process Cytoskeletal Anchoring At Plasma Membrane Pons Development Maintenance Of Cell Polarity Negative Regulation Of Phosphorylation Toxin Metabolic Process Basement Membrane Organization Cerebellar Purkinje Cell Differentiation Regulation Of Metabolic Process Microtubule Cytoskeleton Organization Cerebellar Purkinje Cell Layer Morphogenesis Histone Deubiquitination Membrane Protein Ectodomain Proteolysis Regulation Of Transcription From RNA Polymerase II Promoter System Development NLS-bearing Protein Import Into Nucleus Reflex Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Behavioral Response To Pain Modulation By Virus Of Host Morphology Or Physiology Regulation Of Histone H3-K4 Methylation Neuromuscular Synaptic Transmission Branching Involved In Salivary Gland Morphogenesis Regulation Of Hormone Biosynthetic Process Cell Morphogenesis Involved In Neuron Differentiation Cerebellar Cortex Formation Neurotransmitter Metabolic Process Chromatin Modification Gamma-aminobutyric Acid Signaling Pathway Cell Differentiation In Hindbrain Multicellular Organismal Development Neuron Projection Morphogenesis Calcium Ion Import	Extracellular Matrix Organization Extracellular Structure Organization Response To Stimulus Cell-substrate Junction Assembly Cell-substrate Adhesion Platelet Degranulation Cellular Localization Protein Modification By Small Protein Conjugation Regulation Of Proteolysis Vesicle-mediated Transport Regulation Of Protein Metabolic Process Establishment Of Localization In Cell Cell Junction Assembly Protein Localization To Tight Junction Regulation Of Metabolic Process Histone Deubiquitination Regulation Of Cellular Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Apoptotic Process Cellular Response To Stimulus Regulation Of Cellular Protein Metabolic Process Response To Wounding Regulation Of Protein Catabolic Process Regulation Of Cell Death Protein Ubiquitination Protein Polyubiquitination Blood Coagulation Cellular Protein Modification Process Hemostasis Positive Regulation Of Proteolysis Focal Adhesion Assembly Cellular Component Assembly Protein Localization Extracellular Matrix Disassembly Platelet Activation Regulation Of Signal Transduction Regulation Of Proteasomal Protein Catabolic Process Protein Complex Assembly Regulation Of Signaling Cellular Protein Metabolic Process Protein Localization To Cell Junction Cell Death Death Response To Stress Nervous System Development Positive Regulation Of Protein Catabolic Process Secretion By Cell Substrate Adhesion-dependent Cell Spreading Adherens Junction Assembly Protein Metabolic Process
Tagcloud ?			accounts asian ataxia ataxias atn1 atxn1 atxn2 atxn3 cag caucasians causal causative consortium ethnic expanded expansions explained geographical htt influenced modifier polyglutamine quadratic reflected replicated sister spinocerebellar tbp variability
Tagcloud (Difference) ?			accounts asian ataxia ataxias atn1 atxn1 atxn2 atxn3 cag caucasians causal causative consortium ethnic expanded expansions explained geographical htt influenced modifier polyglutamine quadratic reflected replicated sister spinocerebellar tbp variability
Tagcloud (Intersection) ?