SPATC1 and TUBG1

Number of citations: 0 (PubMedID 15280373)
Data Source: HPRD (in vitro)

		SPATC1	TUBG1
Name		spermatogenesis and centriole associated 1	tubulin gamma 1
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytoskeleton	Pericentriolar Material Condensed Nuclear Chromosome Gamma-tubulin Complex Gamma-tubulin Ring Complex Nucleus Cytoplasm Centrosome Centriole Spindle Polar Microtubule Cytosol Cytoskeleton Microtubule Spindle Microtubule Cytoplasmic Microtubule Cilium Microtubule Cytoskeleton Cell Leading Edge Ciliary Basal Body Neuron Projection Apical Part Of Cell Recycling Endosome Non-motile Cilium Mitotic Spindle Microtubule
	Molecular Function	None	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Identical Protein Binding Microtubule Nucleator Activity
	Biological Process	None	Mitotic Sister Chromatid Segregation Meiotic Spindle Organization Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Microtubule Nucleation Mitotic Spindle Organization Cytoplasmic Microtubule Organization
Pathways		None	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs		None	Vinblastine
GWAS		Bipolar disorder ( 31043756 ) Bipolar I disorder ( 31043756 ) Brain morphology (MOSTest) ( 32665545 ) Fibrinogen levels ( 28107422 ) Mean corpuscular hemoglobin ( 29403010 )	Apolipoprotein A1 levels ( 32203549 ) HDL cholesterol levels ( 32203549 )
Novel Interactors		1 novel interactors: MROH5	6 novel interactors: CTRL PHB1 RARA RND2 SGCA WNT3
Interacting Genes		2 interacting genes: CDC20 TUBG1	31 interacting genes: APP BRCA1 CEBPA CNTN2 CPAP CUL4A DDX41 ERCC3 IKBKG KIF14 KRT18 KRT19 MARK4 NAPG NDE1 OGT PCNT PIK3R1 PLK1 PXN RACGAP1 RACK1 RASSF1 RNF19A RPGR SPATC1 TUBA1B TUBA3C TUBB4B TUBGCP3 TUBGCP4
Entrez ID		375686	7283
HPRD ID		15433	01853
Ensembl ID		ENSG00000186583	ENSG00000131462
Uniprot IDs		A0A140VJV4 Q76KD6	P23258
PDB IDs		Not available	1Z5V 1Z5W 3CB2 6V5V 6V6S 7AS4 7QJ0 7QJ1 7QJ2 7QJ3 7QJ4 7QJ5 7QJ6 7QJ7 7QJ8 7QJ9 7QJA 7QJB 7QJC 7QJD 7QJE 8Q62 8RX1 8VA2 8VRD 8VRJ 8VRK 9H9P
GO Terms Enriched among Interactors		Mitotic Spindle Organization Microtubule Cytoskeleton Organization Involved In Mitosis Metaphase/anaphase Transition Of Meiosis I Spindle Organization Microtubule Nucleator Activity Meiotic Cell Cycle Phase Transition Mitotic Checkpoint Complex Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Spindle Polar Microtubule Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Chromosome Organization Positive Regulation Of Synapse Maturation Metaphase/anaphase Transition Of Cell Cycle Anaphase-promoting Complex Binding Ubiquitin-protein Transferase Activator Activity Positive Regulation Of Synaptic Plasticity Ubiquitin Ligase Activator Activity Microtubule Cytoskeleton Organization Gamma-tubulin Ring Complex Gamma-tubulin Complex Positive Regulation Of Ubiquitin-protein Transferase Activity Mitotic Spindle Microtubule Mitotic Sister Chromatid Cohesion Positive Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Sister Chromatid Separation Anaphase-promoting Complex Meiotic Spindle Organization Pericentriolar Material Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Meiotic Nuclear Division Centrosome Positive Regulation Of Chromosome Separation Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Synapse Maturation Microtubule Nucleation Non-motile Cilium Microtubule-based Process Mitotic Sister Chromatid Segregation Negative Regulation Of Mitotic Nuclear Division Sister Chromatid Segregation Sister Chromatid Cohesion Spindle Microtubule Mitotic Spindle Assembly Positive Regulation Of Mitotic Nuclear Division Condensed Nuclear Chromosome G2/M Transition Of Mitotic Cell Cycle	Microtubule-based Process Cytoskeleton Microtubule Cytoskeleton Organization Cytoskeleton Organization Microtubule Organelle Organization Microtubule Organizing Center Microtubule Nucleation Gamma-tubulin Binding Structural Constituent Of Cytoskeleton Centrosome Regulation Of Cell Cycle Positive Regulation Of Proteolysis Mitotic Cell Cycle Microtubule Cytoskeleton Gamma-tubulin Complex Intracellular Signal Transduction Cytoplasm Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Cycle Regulation Of Programmed Cell Death Signal Transduction Supramolecular Fiber Organization Protein Domain Specific Binding Spindle Regulation Of Protein Catabolic Process Regulation Of Proteolysis Regulation Of Cell Cycle Process Spindle Pole Spindle Midzone Spindle Organization Positive Regulation Of Gene Expression Microtubule Organizing Center Organization Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Cell Division Regulation Of Response To Endoplasmic Reticulum Stress Midbody Regulation Of Protein Metabolic Process Microtubule Polymerization Or Depolymerization Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Hemopoiesis Regulation Of Cellular Response To Stress Substrate Adhesion-dependent Cell Spreading