SPATC1 and TUBG1

Number of citations of the paper that reports this interaction (PMID 15280373)
10

Data Source:
HPRD (in vitro)

		SPATC1	TUBG1
Gene Name		spermatogenesis and centriole associated 1	tubulin, gamma 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Centrosome	Pericentriolar Material Condensed Nuclear Chromosome Gamma-tubulin Complex Cytoplasm Centrosome Centriole Polar Microtubule Cytosol Cytoplasmic Microtubule Cell Leading Edge Nonmotile Primary Cilium Ciliary Basal Body Apical Part Of Cell Recycling Endosome
	Molecular Function	Gamma-tubulin Binding	GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding
	Biological Process		G2/M Transition Of Mitotic Cell Cycle Meiotic Spindle Organization Microtubule Cytoskeleton Organization Mitotic Cell Cycle Organelle Organization Microtubule Nucleation Cytoplasmic Microtubule Organization
Pathways			Organelle biogenesis and maintenance Assembly of the primary cilium G2/M Transition Anchoring of the basal body to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Recruitment of NuMA to mitotic centrosomes Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes Centrosome maturation Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: CDC20 TUBG1	24 interactors: BRCA1 CENPJ CNTN2 IKBKG KRT18 KRT19 MARK4 NAPG NDE1 OLA1 PCNT PIK3R1 PLK1 PXN RACGAP1 RASSF1 RNF19A RPGR SPATC1 TUBA1B TUBA3C TUBB4B TUBGCP3 TUBGCP4
Entrez ID		375686	7283
HPRD ID		15433	01853
Ensembl ID		ENSG00000186583	ENSG00000131462
Uniprot IDs		Q76KD6	P23258
PDB IDs			1Z5V 1Z5W 3CB2
Enriched GO Terms of Interacting Partners?		Activation Of Anaphase-promoting Complex Activity Positive Regulation Of Synaptic Plasticity Mitotic Cell Cycle Process Mitotic Cell Cycle Meiotic Spindle Organization Positive Regulation Of Synapse Maturation Regulation Of Synapse Maturation Microtubule Nucleation Cell Cycle Process Microtubule Polymerization Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Cytoplasmic Microtubule Organization Microtubule Polymerization Or Depolymerization Mitotic Spindle Checkpoint Cell Cycle Negative Regulation Of Chromosome Segregation Regulation Of Meiosis Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Meiotic Cell Cycle Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Proteasomal Protein Catabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Ligase Activity Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Chromosome Organization Regulation Of Synapse Organization Regulation Of Synapse Structure Or Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Protein Polymerization Regulation Of Dendrite Development Negative Regulation Of Protein Catabolic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Mitotic Nuclear Division Spindle Organization Positive Regulation Of Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Microtubule-based Process Microtubule Cytoskeleton Organization Cytoskeleton Organization G2/M Transition Of Mitotic Cell Cycle Protein Polymerization Cellular Protein Complex Assembly Organelle Organization Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle Cell Cycle Process Microtubule Nucleation Cellular Component Assembly Cellular Macromolecular Complex Assembly Microtubule Polymerization Mitotic Cell Cycle Process Protein Complex Assembly Mitotic Cell Cycle Microtubule Polymerization Or Depolymerization Centrosome Organization Microtubule Organizing Center Organization Organelle Assembly Regulation Of Protein Stability Centrosome Cycle 'de Novo' Posttranslational Protein Folding 'de Novo' Protein Folding Cell Division Movement Of Cell Or Subcellular Component Regulation Of Centriole Replication Regulation Of Cell Cycle Process Protein Stabilization Neural Precursor Cell Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cellular Localization Negative Regulation Of Cell Death Spindle Organization Growth Hormone Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Cellular Response To Growth Hormone Stimulus Cytoskeleton-dependent Intracellular Transport Regulation Of Microtubule Cytoskeleton Organization Regulation Of Cell Death Centrosome Duplication G2 DNA Damage Checkpoint Neuron Migration Regulation Of Microtubule-based Process Response To Growth Hormone Regulation Of Centrosome Duplication Positive Regulation Of Protein Metabolic Process
Tagcloud ?			bipolar dcx disorganization dync1h1 electroporation ganglial gyral inputs interchangeability kif2a kif5c malformations mcd mcds polarization polymicrogyria postmitotic radial rescue round stereotyped tbr2 tuba1a tubb2b tubb3 tubb5 tubulin tubulins utero
Tagcloud (Difference) ?			bipolar dcx disorganization dync1h1 electroporation ganglial gyral inputs interchangeability kif2a kif5c malformations mcd mcds polarization polymicrogyria postmitotic radial rescue round stereotyped tbr2 tuba1a tubb2b tubb3 tubb5 tubulin tubulins utero
Tagcloud (Intersection) ?