SLC26A5 and UBE2J1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SLC26A5	UBE2J1
Description		solute carrier family 26 member 5	ubiquitin conjugating enzyme E2 J1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Basolateral Plasma Membrane Lateral Plasma Membrane Lateral Wall Of Outer Hair Cell	Hrd1p Ubiquitin Ligase Complex Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Secondary Active Sulfate Transmembrane Transporter Activity Sulfate Transmembrane Transporter Activity Oxalate Transmembrane Transporter Activity Spectrin Binding Identical Protein Binding Protein Homodimerization Activity Chloride:bicarbonate Antiporter Activity	Nucleotide Binding Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Response To Ischemia Chloride Transport Sensory Perception Of Sound Regulation Of Cell Shape Response To Xenobiotic Stimulus Response To Salicylic Acid Response To Auditory Stimulus Bicarbonate Transport Fructose Transmembrane Transport Oxalate Transport Monoatomic Ion Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Response To Potassium Ion Regulation Of Membrane Potential Positive Regulation Of Cell Size Transmembrane Transport Cochlea Development Response To Thyroid Hormone Monoatomic Anion Transmembrane Transport Response To Salt Sulfate Transmembrane Transport Chloride Transmembrane Transport Positive Regulation Of Cell Motility	Protein Polyubiquitination Spermatid Development Regulation Of Macrophage Cytokine Production Protein Ubiquitination Protein N-linked Glycosylation Via Asparagine Regulation Of Tumor Necrosis Factor Production ERAD Pathway Negative Regulation Of Retrograde Protein Transport, ER To Cytosol
Pathways		Sensory processing of sound by outer hair cells of the cochlea	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Deafness, autosomal recessive
GWAS		Age-related hearing impairment ( 34108613) Femur bone mineral density x serum urate levels interaction ( 34046847) Morning person ( 30696823)
Interacting Genes		1 interacting genes: UBE2J1	50 interacting genes: AQP2 AQP6 BIRC2 BRCA1 CD79A CDS1 CLTRN CREB3 CYB561 DIO2 EBP ELOVL4 FAM209A FAM210B FCER1G GKN1 GOLT1A JAGN1 LAPTM5 LRSAM1 LY6G6C LYVE1 MAPKAPK2 MS4A6E PJA2 PLPPR2 PRKN PROKR2 REEP4 RNF2 SEC11C SLC10A6 SLC26A5 SLC33A2 SLC71A2 SYVN1 TLCD4 TM4SF18 TM4SF19 TMEM14B TMEM31 TMEM51 TMX2 TOPORS TRHR TRIM27 TRIM63 UBA1 UBC UBR5
Entrez ID		375611	51465
HPRD ID		09224	15599
Ensembl ID		ENSG00000170615	ENSG00000198833
Uniprot IDs		P58743	Q9Y385
PDB IDs		7LGU 7LGW 7LH2 7LH3
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Protein Exit From Endoplasmic Reticulum Regulation Of Retrograde Protein Transport, ER To Cytosol Hrd1p Ubiquitin Ligase Complex Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Protein N-linked Glycosylation Via Asparagine Regulation Of Protein Exit From Endoplasmic Reticulum Regulation Of Macrophage Cytokine Production Negative Regulation Of Intracellular Protein Transport Ubiquitin Conjugating Enzyme Activity Negative Regulation Of Intracellular Transport Protein N-linked Glycosylation ERAD Pathway Spermatid Development Negative Regulation Of Protein Transport Regulation Of Cytokine Production Involved In Immune Response Regulation Of Intracellular Protein Transport Negative Regulation Of Establishment Of Protein Localization	Membrane Ubiquitin-protein Transferase Activity Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Polyubiquitination Endoplasmic Reticulum Membrane Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Protein Binding Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Modification-dependent Protein Catabolic Process Renal Water Transport Protein K48-linked Ubiquitination Transferase Activity Ubiquitin Ligase Complex Negative Regulation Of Response To Endoplasmic Reticulum Stress Protein K29-linked Ubiquitination Protein Modification Process
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