ARHGAP21 and VPS26C

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		ARHGAP21	VPS26C
Description		Rho GTPase activating protein 21	VPS26 endosomal protein sorting factor C
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GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton Membrane Cell Junction Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Anchoring Junction	Nucleus Endosome
	Molecular Function	GTPase Activator Activity Protein Binding	Protein Binding
	Biological Process	Golgi Organization Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Golgi Localization Establishment Of Golgi Localization Maintenance Of Golgi Location Organelle Transport Along Microtubule	Intracellular Protein Transport Endocytic Recycling
Pathways		RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle RND3 GTPase cycle
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Appendicular lean mass ( 33097823) Birth weight ( 31043758) Diisocyanate-induced asthma ( 25918132) Immature fraction of reticulocytes ( 32888494) Lobe attachment (rater scored) ( 29198719) Lobe attachment (rater-scored or self-reported) ( 29198719) Optic disc area ( 31798171) Optic disc size ( 31809533) Stress sensitivity (neuroticism score x major depressive disorder status interaction) ( 30571770) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		9 interacting genes: ARF1 EEF1D PCNT PTK2B RHOA SP1 TULP3 VPS26C ZNF177	44 interacting genes: AGTPBP1 ARHGAP21 ASH1L CBLB CCDC85A CIPC DCLK1 DDIT4L DECR2 DNAJB2 EPHB6 INCA1 KIF1A KIF21A LRIF1 MAML3 MAPK6 MAPK8IP1 MDM4 MEI4 MEOX2 MRPS35 MYRIP NRCAM NSMF PALS2 PCM1 PEG10 PMS2 PRKD2 PTPN21 RAB39B RAP1GAP RAP1GAP2 SETMAR TAF1C TEPSIN TET2 TRAPPC1 U2AF1 VPS26A VPS35L XPA ZNF655
Entrez ID		57584	10311
HPRD ID		06445	10390
Ensembl ID		ENSG00000107863	ENSG00000157538
Uniprot IDs		A0A805TBS0 Q5T5U3	A8MTY9 A8MY26 O14972
PDB IDs		2DHJ 2J59 2YUY	8P0X 8SYN 8SYO 9AU7
Enriched GO Terms of Interacting Partners?		Mitotic Cytokinetic Process Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Organization Regulation Of Actin Filament-based Process Cleavage Furrow Ingression Membrane Invagination Regulation Of Supramolecular Fiber Organization Cytokinetic Process Mitotic Cleavage Furrow Ingression Aortic Valve Formation Regulation Of Endothelial Cell Migration Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Lymphocyte Migration Positive Regulation Of Vascular Associated Smooth Muscle Contraction Endothelial Tube Lumen Extension Mitotic Cleavage Furrow Formation Positive Regulation Of Lymphocyte Migration Skeletal Muscle Satellite Cell Migration Neurotransmitter Receptor Regulator Activity Positive Regulation Of B Cell Chemotaxis Positive Regulation Of Hydrogen Sulfide Biosynthetic Process Cellular Response To Wortmannin Response To Wortmannin Bronchus Morphogenesis Ciliary Base Mitotic Spindle Organization Positive Regulation Of Mononuclear Cell Migration Focal Adhesion Beta Selection Intraciliary Transport Particle A Binding
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