ITPKA and CAMK2B

Number of citations of the paper that reports this interaction (PMID 11468283)
18

Data Source:
HPRD (in vivo)

		ITPKA	CAMK2B
Gene Name		inositol-trisphosphate 3-kinase A	calcium/calmodulin-dependent protein kinase II beta
Image
Gene Ontology Annotations	Cellular Component	Cytosol Dendritic Spine	Nucleoplasm Microtubule Organizing Center Cytosol Plasma Membrane Endocytic Vesicle Membrane Sarcoplasmic Reticulum Membrane Spindle Midzone
	Molecular Function	Calmodulin-dependent Protein Kinase Activity Calmodulin Binding ATP Binding Inositol-1,4,5-trisphosphate 3-kinase Activity Rac GTPase Binding	Actin Binding Calmodulin-dependent Protein Kinase Activity Calmodulin Binding ATP Binding Protein Homodimerization Activity
	Biological Process	Inositol Metabolic Process Protein Phosphorylation Signal Transduction Actin Cytoskeleton Organization Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Regulation Of Synaptic Plasticity Positive Regulation Of Dendritic Spine Morphogenesis Dendritic Spine Maintenance	G1/S Transition Of Mitotic Cell Cycle Inhibitory G-protein Coupled Receptor Phosphorylation Protein Phosphorylation Calcium Ion Transport Signal Transduction Synaptic Transmission Positive Regulation Of Neuron Projection Development Regulation Of Skeletal Muscle Adaptation Peptidyl-serine Phosphorylation Cytokine-mediated Signaling Pathway Regulation Of Synaptic Transmission, Cholinergic Cellular Response To Heat Response To Cadmium Ion Protein Autophosphorylation Regulation Of Long-term Neuronal Synaptic Plasticity Neuromuscular Process Controlling Balance Regulation Of Synapse Structural Plasticity Regulation Of Calcium Ion Transport Interferon-gamma-mediated Signaling Pathway Activation Of Meiosis Involved In Egg Activation Regulation Of Dendritic Spine Development Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Synapse Maturation Regulation Of Cellular Response To Heat Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Synthesis of IP3 and IP4 in the cytosol Inositol phosphate metabolism	Interferon Signaling Cytokine Signaling in Immune system Cellular response to heat stress CREB phosphorylation through the activation of Ras Trafficking of AMPA receptors Interferon gamma signaling HSF1-dependent transactivation Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Unblocking of NMDA receptor, glutamate binding and activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs		Inositol 1,3,4,5-Tetrakisphosphate D-Myo-Inositol-1,4,5-Triphosphate Adenosine-5\'-Diphosphate Phosphoaminophosphonic Acid-Adenylate Ester
Diseases
GWAS		Ulcerative colitis ( 23128233)	Metabolic syndrome ( 22399527)
Protein-Protein Interactions		7 interactors: ACTA1 CALM1 CAMK2A CAMK2B ITSN2 PRKACA PRKCA	37 interactors: ACOT7 ACTN4 AP5B1 ATXN1 CAMK2D CAMK2N2 CCM2L COL4A3 ETS1 FAM171A2 GAPDH GRIN2A GRIN2B ITPKA KRTAP10-11 KRTAP19-5 KRTAP19-7 MAD2L2 MED18 MGAT5B MORF4L1 MRPL11 MVP PHKB PLCB3 POP5 RAP2B RBFOX2 RBPMS RPL11 RXRG SEMA4G SMYD3 SPRYD7 THRB TTC5 YWHAB
Entrez ID		3706	816
HPRD ID		00941	12127
Ensembl ID		ENSG00000137825	ENSG00000058404
Uniprot IDs		P23677	A4D2J9 Q13554
PDB IDs		1W2C 1W2D 1W2F	3BHH
Enriched GO Terms of Interacting Partners?		Peptidyl-serine Phosphorylation Regulation Of Rhodopsin Mediated Signaling Pathway Activation Of Adenylate Cyclase Activity Response To Abiotic Stimulus Positive Regulation Of Dense Core Granule Biogenesis Rhodopsin Mediated Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Adenylate Cyclase Activity Regulation Of Calcium Ion Transport Synaptic Transmission Histone H3-T6 Phosphorylation Protein Autophosphorylation Positive Regulation Of Lyase Activity Activation Of Phospholipase C Activity Regulation Of Adenylate Cyclase Activity Positive Regulation Of Phospholipase C Activity Positive Regulation Of CAMP Biosynthetic Process Regulation Of Cyclase Activity Positive Regulation Of CAMP Metabolic Process Innate Immune Response Positive Regulation Of Phospholipase Activity Phototransduction, Visible Light Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of Phospholipase Activity Regulation Of CAMP Biosynthetic Process Cell-cell Signaling Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Lipase Activity Detection Of Visible Light Cellular Response To Light Stimulus Phototransduction Regulation Of CAMP Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Detection Of Light Stimulus Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Negative Regulation Of Glucose Import Positive Regulation Of Macrophage Differentiation Desmosome Organization Energy Reserve Metabolic Process Cellular Response To Radiation Immune Response Response To Organic Substance Regulation Of Muscle Contraction Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Glucose Transport Regulation Of Platelet Aggregation Epidermal Growth Factor Receptor Signaling Pathway Defense Response	Negative Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Excitatory Postsynaptic Membrane Potential Intracellular Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Postsynaptic Membrane Potential Regulation Of Cellular Protein Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Response To Stimulus Regulation Of Protein Phosphorylation Regulation Of Transcription From RNA Polymerase II Promoter Membrane Depolarization Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Transferase Activity Startle Response Regulation Of RNA Biosynthetic Process Cellular Metabolic Process Retinoic Acid Receptor Signaling Pathway Neuromuscular Process Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Protein Autophosphorylation Positive Regulation Of Phosphorylation Regulation Of RNA Metabolic Process Learning Positive Regulation Of Metabolic Process Response To Stress Gene Expression Synaptic Transmission Cardiac Muscle Tissue Growth Regulation Of Erythrocyte Differentiation Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Transcription, DNA-templated Regulation Of Synaptic Plasticity Palmitic Acid Biosynthetic Process Peptidyl-cysteine S-trans-nitrosylation Medium-chain Fatty-acyl-CoA Catabolic Process Long-chain Fatty-acyl-CoA Catabolic Process System Development Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Cellular Response To Steroid Hormone Stimulus Sensory Perception Of Mechanical Stimulus Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Phosphorylation
Tagcloud ?		aberrant aberrantly accessible bcor cd127 contributors covering cxcl14 fzd5 fzd8 granulocyte hes6 hic1 hypermethylated hypomorphic island leukemic megakaryocyte prdm16 preleukemic progenitors pu publicly robo3 runx1 sca shortage tal1 underscoring	1alpha apoptosis apoptotic bcl2 calmodulin enos ep300 epo explore expressions hhcy hif homocysteine hyperhomocysteinemia involvement itraq lower methoxyestradiol mtt neurons overexpression percentage presumed protects suppressed technique transfection tried
Tagcloud (Difference) ?		aberrant aberrantly accessible bcor cd127 contributors covering cxcl14 fzd5 fzd8 granulocyte hes6 hic1 hypermethylated hypomorphic island leukemic megakaryocyte prdm16 preleukemic progenitors pu publicly robo3 runx1 sca shortage tal1 underscoring	1alpha apoptosis apoptotic bcl2 calmodulin enos ep300 epo explore expressions hhcy hif homocysteine hyperhomocysteinemia involvement itraq lower methoxyestradiol mtt neurons overexpression percentage presumed protects suppressed technique transfection tried
Tagcloud (Intersection) ?