ITPKA

Gene Name		inositol-trisphosphate 3-kinase A
Image
Gene Ontology Annotations	Cellular Component	Cytosol Dendritic Spine
	Molecular Function	Calmodulin-dependent Protein Kinase Activity Calmodulin Binding ATP Binding Inositol-1,4,5-trisphosphate 3-kinase Activity Rac GTPase Binding
	Biological Process	Inositol Metabolic Process Protein Phosphorylation Signal Transduction Actin Cytoskeleton Organization Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Regulation Of Synaptic Plasticity Positive Regulation Of Dendritic Spine Morphogenesis Dendritic Spine Maintenance
Pathways		Synthesis of IP3 and IP4 in the cytosol Inositol phosphate metabolism
Drugs		Inositol 1,3,4,5-Tetrakisphosphate D-Myo-Inositol-1,4,5-Triphosphate Adenosine-5\'-Diphosphate Phosphoaminophosphonic Acid-Adenylate Ester
Diseases
GWAS		Ulcerative colitis ( 23128233)
Protein-protein Interactions		7 interactors: ACTA1 CALM1 CAMK2A CAMK2B ITSN2 PRKACA PRKCA
Entrez ID		3706
HPRD ID		00941
Ensembl ID		ENSG00000137825
Uniprot IDs		P23677
PDB IDs		1W2C 1W2D 1W2F
Enriched GO Terms of Interacting Partners?		Peptidyl-serine Phosphorylation Regulation Of Rhodopsin Mediated Signaling Pathway Activation Of Adenylate Cyclase Activity Response To Abiotic Stimulus Positive Regulation Of Dense Core Granule Biogenesis Rhodopsin Mediated Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Adenylate Cyclase Activity Regulation Of Calcium Ion Transport Synaptic Transmission Histone H3-T6 Phosphorylation Protein Autophosphorylation Positive Regulation Of Lyase Activity Activation Of Phospholipase C Activity Regulation Of Adenylate Cyclase Activity Positive Regulation Of Phospholipase C Activity Positive Regulation Of CAMP Biosynthetic Process Regulation Of Cyclase Activity Positive Regulation Of CAMP Metabolic Process Innate Immune Response Positive Regulation Of Phospholipase Activity Phototransduction, Visible Light Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of Phospholipase Activity Regulation Of CAMP Biosynthetic Process Cell-cell Signaling Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Lipase Activity Detection Of Visible Light Cellular Response To Light Stimulus Phototransduction Regulation Of CAMP Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Detection Of Light Stimulus Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Negative Regulation Of Glucose Import Positive Regulation Of Macrophage Differentiation Desmosome Organization Energy Reserve Metabolic Process Cellular Response To Radiation Immune Response Response To Organic Substance Regulation Of Muscle Contraction Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Glucose Transport Regulation Of Platelet Aggregation Epidermal Growth Factor Receptor Signaling Pathway Defense Response
Tagcloud ?		aberrant aberrantly accessible bcor cd127 contributors covering cxcl14 fzd5 fzd8 granulocyte hes6 hic1 hypermethylated hypomorphic island leukemic megakaryocyte prdm16 preleukemic progenitors pu publicly robo3 runx1 sca shortage tal1 underscoring