FCER2 and ITGAX

Number of citations of the paper that reports this interaction (PubMedID 7621072)
0

Data Source:
HPRD (in vivo)

		FCER2	ITGAX
Description		Fc epsilon receptor II	integrin subunit alpha X
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane Extracellular Exosome	Plasma Membrane Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Secretory Granule Membrane Integrin AlphaX-beta2 Complex Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Protease Binding Integrin Binding Protein Binding Low-affinity IgE Receptor Activity IgE Binding Carbohydrate Binding Pattern Recognition Receptor Activity Metal Ion Binding	Integrin Binding Protein Binding Receptor Tyrosine Kinase Binding Signaling Receptor Activity Metal Ion Binding
	Biological Process	B Cell Antigen Processing And Presentation Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Immune Response Positive Regulation Of Gene Expression Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Macrophage Activation Defense Response To Bacterium Fc Receptor-mediated Immune Complex Endocytosis	Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cell Migration Positive Regulation Of Myelination Heterotypic Cell-cell Adhesion Positive Regulation Of Angiogenesis Defense Response To Virus Cell-cell Adhesion Positive Regulation Of Endothelial Tube Morphogenesis
Pathways		NOTCH2 intracellular domain regulates transcription Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling	Cell surface interactions at the vascular wall Integrin cell surface interactions ECM proteoglycans Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation
Drugs		Lumiliximab	Efalizumab
Diseases
GWAS		Blood protein levels ( 30072576) Post bronchodilator FEV1 ( 26634245)	IgA nephropathy ( 25305756) Post bronchodilator FEV1 ( 26634245) Systemic lupus erythematosus ( 18204098)
Interacting Genes		6 interacting genes: ATF7 CR2 FYN ITGAX ITGB2 XRCC6	5 interacting genes: C3 FCER2 ITGB2 JAM3 MIA3
Entrez ID		2208	3687
HPRD ID		01049	01051
Ensembl ID		ENSG00000104921	ENSG00000140678
Uniprot IDs		K3W4U1 P06734	H3BN02 P20702
PDB IDs		1T8C 1T8D 2H2R 2H2T 4EZM 4G96 4G9A 4GI0 4GJ0 4GJX 4GK1 4GKO 4J6J 4J6K 4J6L 4J6M 4J6N 4J6P 4J6Q 4KI1 5LGK 6Y0L 6Y0M	1N3Y 2LUV 3K6S 3K71 3K72 4NEH 4NEN 5ES4
Enriched GO Terms of Interacting Partners?		Integrin AlphaX-beta2 Complex Positive Regulation Of Immune Response Positive Regulation Of Protein Targeting To Membrane Integrin Complex Regulation Of Protein Targeting To Membrane Heterotypic Cell-cell Adhesion Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Vasculature Development Protein-containing Complex Binding Regulation Of Angiogenesis Ficolin-1-rich Granule Membrane Tertiary Granule Membrane Scaffold Protein Binding Activation Of Immune Response Cellular Response To Glycine Response To Singlet Oxygen Leukocyte Activation Defense Response Lymphocyte Proliferation Response To Glycine Regulation Of Multicellular Organismal Development Cell-matrix Adhesion Positive Regulation Of Endothelial Tube Morphogenesis Integrin-mediated Signaling Pathway Integrin AlphaM-beta2 Complex Integrin AlphaL-beta2 Complex Mononuclear Cell Proliferation Leukocyte Proliferation Cell Activation Response To Stress Regulation Of Immune System Process Regulation Of Protein Modification Process Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Cell Shape Negative Regulation Of Hydrogen Peroxide Biosynthetic Process DNA End Binding Ku70:Ku80 Complex ICAM-3 Receptor Activity Positive Regulation Of Neutrophil Degranulation Integrin Binding Positive Regulation Of Multicellular Organismal Process Cell-substrate Adhesion CD8 Receptor Binding Type 5 Metabotropic Glutamate Receptor Binding Negative Regulation Of Dopamine Metabolic Process Immune System Process Negative Regulation Of Dendritic Spine Maintenance Growth Factor Receptor Binding Cellular Hyperosmotic Salinity Response	Positive Regulation Of Immune System Process Regulation Of Immune System Process Integrin Binding Positive Regulation Of Humoral Immune Response Leukocyte Migration Involved In Inflammatory Response Leukocyte Migration Amyloid-beta Clearance Cargo Receptor Activity Positive Regulation Of Immune Effector Process Cell Migration Cellular Response To Low-density Lipoprotein Particle Stimulus Heterotypic Cell-cell Adhesion Cellular Response To Lipoprotein Particle Stimulus Positive Regulation Of Immunoglobulin Mediated Immune Response Cell Motility Regulation Of Humoral Immune Response Macrophage Activation Endothelial Cell Migration C5L2 Anaphylatoxin Chemotactic Receptor Binding Low-affinity IgE Receptor Activity Granulocyte Migration Regulation Of Actin Cytoskeleton Organization By Cell-cell Adhesion Leukocyte Activation Cell-matrix Adhesion Positive Regulation Of Immune Response Positive Regulation Of Activation Of Membrane Attack Complex Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Cell Activation Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Adaptive Immune Response B Cell Antigen Processing And Presentation Myeloid Leukocyte Activation Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Myeloid Leukocyte Migration Integrin AlphaL-beta2 Complex Leukocyte Chemotaxis Immune System Process Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Complement-dependent Cytotoxicity Classical-complement-pathway C3/C5 Convertase Complex Vertebrate Eye-specific Patterning Fc Receptor-mediated Immune Complex Endocytosis ICAM-3 Receptor Activity Positive Regulation Of Neutrophil Degranulation Cell-substrate Adhesion Negative Regulation Of Integrin Activation Regulation Of Cell Adhesion Receptor-mediated Endocytosis
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