ISL1 and NR2F1

Number of citations of the paper that reports this interaction (PMID 11043578)
5

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		ISL1	NR2F1
Gene Name		ISL LIM homeobox 1	nuclear receptor subfamily 2, group F, member 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion	Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Coactivator Activity Enhancer Sequence-specific DNA Binding Chromatin Binding Zinc Ion Binding Ligand-dependent Nuclear Receptor Binding Estrogen Receptor Binding BHLH Transcription Factor Binding	Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Coactivator Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Retinoic Acid-responsive Element Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Neural Crest Cell Migration Secondary Heart Field Specification Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Endocardial Cushion Morphogenesis Cardiac Right Ventricle Morphogenesis Regulation Of Secondary Heart Field Cardioblast Proliferation Positive Regulation Of Cell Proliferation Positive Regulation Vascular Endothelial Growth Factor Production Spinal Cord Motor Neuron Cell Fate Specification Spinal Cord Motor Neuron Differentiation Visceral Motor Neuron Differentiation Trigeminal Nerve Development Pituitary Gland Development Pancreas Development Axon Regeneration Retinal Ganglion Cell Axon Guidance Positive Regulation Of Insulin Secretion Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of DNA Binding Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Neuron Fate Specification Mesenchymal Cell Differentiation Sensory System Development Peripheral Nervous System Neuron Axonogenesis Negative Regulation Of Inflammatory Response Ventricular Cardiac Muscle Tissue Morphogenesis Pharyngeal System Development Cardiac Muscle Cell Myoblast Differentiation Innervation Atrial Septum Morphogenesis Cardiac Cell Fate Determination Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Granulocyte Colony-stimulating Factor Production Negative Regulation Of Protein Homodimerization Activity Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Macrophage Colony-stimulating Factor Production	Negative Regulation Of Transcription From RNA Polymerase II Promoter Neuron Migration Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Gene Expression Negative Regulation Of Neuron Projection Development Cerebral Cortex Regionalization Intracellular Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Peptide hormone metabolism Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Incretin synthesis, secretion, and inactivation	Generic Transcription Pathway Nuclear Receptor transcription pathway
Drugs
Diseases
GWAS		Dental caries ( 23259602)
Protein-Protein Interactions		20 interactors: APP CDK6 CDKN2B ESR1 ISL2 KDM1A LDB1 LDB2 LHX1 LHX3 LHX4 LMO2 LMX1A NR2F1 PECR RELA RLIM SMAD3 SSBP4 ZNF511	21 interactors: AHR BCL11A BCL11B CBX5 COPS2 EEF1D ESR1 GRIP1 GTF2B HNF4A ISL1 MAP6 NCOA1 NCOA3 NCOR2 NSD1 PFDN1 PHB2 RXRA SP1 THRA
Entrez ID		3670	7025
HPRD ID		02650	00584
Ensembl ID		ENSG00000016082	ENSG00000175745
Uniprot IDs		P61371	F1DAL7 F1DAL9 P10589
PDB IDs			2EBL
Enriched GO Terms of Interacting Partners?		Organ Development Positive Regulation Of Gene Expression Regulation Of Gene Expression Regulation Of Cell Differentiation Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process System Development Cell Differentiation Gene Expression Central Nervous System Development Cell Development Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Differentiation Multicellular Organismal Development Anatomical Structure Development Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Central Nervous System Neuron Differentiation Regulation Of Erythrocyte Differentiation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Developmental Process Forebrain Development Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Brain Development Biosynthetic Process Generation Of Neurons Head Development Cellular Nitrogen Compound Metabolic Process Ventral Spinal Cord Development Positive Regulation Of Metabolic Process Neurogenesis Cell Differentiation In Spinal Cord Nervous System Development Response To External Stimulus Axon Guidance Nitrogen Compound Metabolic Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Regulation Of RNA Metabolic Process Gland Development Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Intracellular Receptor Signaling Pathway RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Multicellular Organismal Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Development System Development DNA-templated Transcription, Initiation Organ Development Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Developmental Process Negative Regulation Of Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Reproductive Process Negative Regulation Of Biosynthetic Process Organ Morphogenesis Developmental Process Involved In Reproduction Response To Steroid Hormone Anatomical Structure Morphogenesis Negative Regulation Of Transcription From RNA Polymerase II Promoter Mammary Gland Development Cellular Response To Steroid Hormone Stimulus Cellular Response To Hormone Stimulus
Tagcloud ?		3f8 achieving antimouse b4galnt1 binary bm concordance enrollment gd2 immunoglobulin immunotherapy individualize individually kaplan killer meier missing mrd multivariable neuroblastoma os pfs phox2b postmrd postmrdsum predictive remission sum univariable	advantageous appearing begins coincides comprise embryoid emerge hesc hescs hipsc hipscs irx2 lastly manifested nestin neural neuroectoderm nr2f2 oct4 otx2 pax6 pluripotency precedes primitive pyramidal rosette rosettes serotonergic sox1
Tagcloud (Difference) ?		3f8 achieving antimouse b4galnt1 binary bm concordance enrollment gd2 immunoglobulin immunotherapy individualize individually kaplan killer meier missing mrd multivariable neuroblastoma os pfs phox2b postmrd postmrdsum predictive remission sum univariable	advantageous appearing begins coincides comprise embryoid emerge hesc hescs hipsc hipscs irx2 lastly manifested nestin neural neuroectoderm nr2f2 oct4 otx2 pax6 pluripotency precedes primitive pyramidal rosette rosettes serotonergic sox1
Tagcloud (Intersection) ?