ISL1 and CDKN2B

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ISL1	CDKN2B
Gene Name		ISL LIM homeobox 1	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Coactivator Activity Enhancer Sequence-specific DNA Binding Chromatin Binding Zinc Ion Binding Ligand-dependent Nuclear Receptor Binding Estrogen Receptor Binding BHLH Transcription Factor Binding	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Neural Crest Cell Migration Secondary Heart Field Specification Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Endocardial Cushion Morphogenesis Cardiac Right Ventricle Morphogenesis Regulation Of Secondary Heart Field Cardioblast Proliferation Positive Regulation Of Cell Proliferation Positive Regulation Vascular Endothelial Growth Factor Production Spinal Cord Motor Neuron Cell Fate Specification Spinal Cord Motor Neuron Differentiation Visceral Motor Neuron Differentiation Trigeminal Nerve Development Pituitary Gland Development Pancreas Development Axon Regeneration Retinal Ganglion Cell Axon Guidance Positive Regulation Of Insulin Secretion Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of DNA Binding Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Neuron Fate Specification Mesenchymal Cell Differentiation Sensory System Development Peripheral Nervous System Neuron Axonogenesis Negative Regulation Of Inflammatory Response Ventricular Cardiac Muscle Tissue Morphogenesis Pharyngeal System Development Cardiac Muscle Cell Myoblast Differentiation Innervation Atrial Septum Morphogenesis Cardiac Cell Fate Determination Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Granulocyte Colony-stimulating Factor Production Negative Regulation Of Protein Homodimerization Activity Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Macrophage Colony-stimulating Factor Production	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Liver Development Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Cell Cycle Arrest Mitotic Cell Cycle Checkpoint Transforming Growth Factor Beta Receptor Signaling Pathway Aging Negative Regulation Of Cell Proliferation Gene Expression Response To Organic Cyclic Compound Megakaryocyte Differentiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Epithelial Cell Differentiation Cellular Response To Extracellular Stimulus Cellular Response To Nutrient Response To Cytokine Negative Regulation Of Phosphorylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Spleen Development Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Peptide hormone metabolism Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Incretin synthesis, secretion, and inactivation	Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Cellular Senescence Oncogene Induced Senescence TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway Mitotic G1-G1/S phases TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer G1 Phase Senescence-Associated Secretory Phenotype (SASP) TGFBR1 KD Mutants in Cancer Cell Cycle, Mitotic Loss of Function of TGFBR1 in Cancer Cyclin D associated events in G1 Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Oxidative Stress Induced Senescence SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Dental caries ( 23259602)	Ankle-brachial index ( 22199011) Breast cancer ( 23535729 20453838) Coronary artery calcification ( 22144573 23561647) Coronary heart disease ( 21626137 21971053 17554300 21378990) Endometriosis ( 23104006) Fasting glucose-related traits (interaction with BMI) ( 22581228) Glaucoma ( 22792221) Glaucoma (primary open-angle) ( 22419738) Glioma ( 21531791 19578367) Intracranial aneurysm ( 18997786 20364137) Myocardial infarction ( 17478679) Myocardial infarction (early onset) ( 19198609) Nasopharyngeal carcinoma ( 20512145) Type 2 diabetes ( 21573907 18372903 22293688 22961080 20581827 19401414 17463246 17463248 17463249 19056611) Vertical cup-disc ratio ( 20548946)
Protein-Protein Interactions		20 interactors: APP CDK6 CDKN2B ESR1 ISL2 KDM1A LDB1 LDB2 LHX1 LHX3 LHX4 LMO2 LMX1A NR2F1 PECR RELA RLIM SMAD3 SSBP4 ZNF511	15 interactors: APP ARPC3 CCDC33 CCDC90B CDK4 CDK6 CDK8 IKBKAP ISL1 KIAA1377 MAGEA11 NIF3L1 TGFB1I1 TRAF1 ZBTB17
Entrez ID		3670	1030
HPRD ID		02650	02696
Ensembl ID		ENSG00000016082	ENSG00000147883
Uniprot IDs		P61371	K7PPU3 P42772
PDB IDs
Enriched GO Terms of Interacting Partners?		Organ Development Positive Regulation Of Gene Expression Regulation Of Gene Expression Regulation Of Cell Differentiation Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process System Development Cell Differentiation Gene Expression Central Nervous System Development Cell Development Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Differentiation Multicellular Organismal Development Anatomical Structure Development Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Central Nervous System Neuron Differentiation Regulation Of Erythrocyte Differentiation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Developmental Process Forebrain Development Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Brain Development Biosynthetic Process Generation Of Neurons Head Development Cellular Nitrogen Compound Metabolic Process Ventral Spinal Cord Development Positive Regulation Of Metabolic Process Neurogenesis Cell Differentiation In Spinal Cord Nervous System Development Response To External Stimulus Axon Guidance Nitrogen Compound Metabolic Process	Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Notch Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Cell Cycle Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Regulation Of Protein Phosphorylation Signal Transduction Regulation Of G2/M Transition Of Mitotic Cell Cycle Signaling Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Transcription, DNA-templated Regulation Of Phosphorylation Protein Phosphorylation Cell Communication Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Differentiation Regulation Of RNA Metabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Cell Cycle Phase Transition Regulation Of Kinase Activity Positive Regulation Of Fibroblast Proliferation Regulation Of Phosphorus Metabolic Process Cell Dedifferentiation Anatomical Structure Morphogenesis Cell Projection Morphogenesis Cell Part Morphogenesis Transcription From RNA Polymerase II Promoter Anatomical Structure Development Response To Stimulus Regulation Of Nitrogen Compound Metabolic Process Axon Guidance Positive Regulation Of Macrophage Colony-stimulating Factor Production Synaptic Growth At Neuromuscular Junction Positive Regulation Of Granulocyte Colony-stimulating Factor Production 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Pancreas Development Regulation Of Fibroblast Proliferation Forebrain Development Negative Regulation Of Cell Cycle Phosphorylation Cell Morphogenesis
Tagcloud ?		3f8 achieving antimouse b4galnt1 binary bm concordance enrollment gd2 immunoglobulin immunotherapy individualize individually kaplan killer meier missing mrd multivariable neuroblastoma os pfs phox2b postmrd postmrdsum predictive remission sum univariable	a134c abp allelic ankyrin balb cdk6 cdnas chr congenic d2 dba g232a ifna inbred inefficient ink4c le multigenic mus p15 p16 p18 pctr1 plasmacytoma pristane spretus typed
Tagcloud (Difference) ?		3f8 achieving antimouse b4galnt1 binary bm concordance enrollment gd2 immunoglobulin immunotherapy individualize individually kaplan killer meier missing mrd multivariable neuroblastoma os pfs phox2b postmrd postmrdsum predictive remission sum univariable	a134c abp allelic ankyrin balb cdk6 cdnas chr congenic d2 dba g232a ifna inbred inefficient ink4c le multigenic mus p15 p16 p18 pctr1 plasmacytoma pristane spretus typed
Tagcloud (Intersection) ?