INSRR and CTDSP2

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		INSRR	CTDSP2
Description		insulin receptor related receptor	CTD small phosphatase 2
Image
GO Annotations	Cellular Component	Plasma Membrane Insulin Receptor Complex Membrane Axon Receptor Complex	Nucleus Nucleoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Insulin Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Phosphatidylinositol 3-kinase Binding Insulin Receptor Substrate Binding	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Hydrolase Activity Phosphatase Activity Metal Ion Binding
	Biological Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Insulin Receptor Signaling Pathway Actin Cytoskeleton Organization Male Sex Determination Protein Autophosphorylation Cellular Response To Alkaline PH	Regulation Of Transcription By RNA Polymerase II Protein Dephosphorylation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			XBP1(S) activates chaperone genes
Drugs		Fostamatinib
Diseases
GWAS		Uric acid clearance ( 28095793)	Height ( 31562340) Hematocrit ( 32888494) Metabolite levels ( 23823483) Refractive error ( 32231278) Trochanter size ( 31053729)
Interacting Genes		5 interacting genes: CTDSP2 INSR KRT27 MEOX2 STYX	13 interacting genes: AKT1 AR CDCA3 CSF1R EPHA1 EPHA3 INSRR LCN2 N4BP3 POLR2A PTK7 SNAI1 TYRO3
Entrez ID		3645	10106
HPRD ID		00976	12281
Ensembl ID		ENSG00000027644	ENSG00000175215
Uniprot IDs		P14616	O14595
PDB IDs		7PL4 7TYJ 7TYK 7TYM	2Q5E
Enriched GO Terms of Interacting Partners?			Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Response To Lipid ATP Binding Receptor Complex Transferase Activity Response To Lipid Negative Regulation Of Apoptotic Process Cellular Response To Oxygen-containing Compound Cell Migration Cellular Response To Ether Signal Transduction Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Migration Male Sex Determination Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Positive Regulation Of Cell Motility Kinase Binding Positive Regulation Of Locomotion Phosphatidylinositol 3-kinase Binding Cell Motility Regulation Of Protein Localization To Plasma Membrane Protein Autophosphorylation Protein Phosphorylation Response To Ether Negative Regulation Of Toll-like Receptor Signaling Pathway Sex Determination Positive Regulation Of Cellular Component Organization Positive Regulation Of Cell Projection Organization Nucleotide Binding Phosphorylation Regulation Of Cellular Component Organization Regulation Of Protein Localization To Cell Periphery Tissue Morphogenesis Cellular Response To Cytokine Stimulus Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Regulation Of Protein Localization To Membrane Positive Regulation Of Morphogenesis Of An Epithelium Regulation Of Toll-like Receptor Signaling Pathway Developmental Process Involved In Reproduction Regulation Of Apoptotic Process Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor
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