INSRR and STYX

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		INSRR	STYX
Description		insulin receptor related receptor	serine/threonine/tyrosine interacting protein
Image
GO Annotations	Cellular Component	Plasma Membrane Insulin Receptor Complex Membrane Axon Receptor Complex	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Insulin Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Phosphatidylinositol 3-kinase Binding Insulin Receptor Substrate Binding	Pseudophosphatase Activity Protein Binding F-box Domain Binding
	Biological Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Insulin Receptor Signaling Pathway Actin Cytoskeleton Organization Male Sex Determination Protein Autophosphorylation Cellular Response To Alkaline PH	Negative Regulation Of Protein Binding Negative Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Regulation Of ERK1 And ERK2 Cascade
Pathways
Drugs		Fostamatinib
Diseases
GWAS		Uric acid clearance ( 28095793)	Prostate cancer ( 23535732)
Interacting Genes		5 interacting genes: CTDSP2 INSR KRT27 MEOX2 STYX	24 interacting genes: AATK CARHSP1 EGFR EPHA2 EPHA3 EPHA7 EPHB6 ERBB2 ERBB3 ERBB4 FBXO7 FBXW7 IGF1R INSR INSRR KDR KIT LMTK2 MAPK1 MUSK PTK7 ROR1 ROR2 TEK
Entrez ID		3645	6815
HPRD ID		00976	10258
Ensembl ID		ENSG00000027644	ENSG00000198252
Uniprot IDs		P14616	Q8WUJ0
PDB IDs		7PL4 7TYJ 7TYK 7TYM	2R0B
Enriched GO Terms of Interacting Partners?			Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Kinase Activity Receptor Complex Enzyme-linked Receptor Protein Signaling Pathway ATP Binding Nucleotide Binding Transferase Activity Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Phosphorylation Protein Phosphorylation Growth Factor Binding ERBB2 Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of MAPK Cascade Protein Autophosphorylation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Insulin Receptor Activity Signal Transduction Ephrin Receptor Activity Regulation Of ERK1 And ERK2 Cascade Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphate Metabolic Process Peptidyl-tyrosine Phosphorylation Animal Organ Development Insulin Receptor Complex Coreceptor Activity Positive Regulation Of Protein Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Basal Plasma Membrane Positive Regulation Of Cell Migration Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Locomotion ERBB Signaling Pathway Regulation Of Phosphorylation Regulation Of Developmental Process Phosphate-containing Compound Metabolic Process Plasma Membrane Regulation Of Protein Modification Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling
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