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ING1 and NQO1
Number of citations of the paper that reports this interaction (PubMedID
18388957
)
22
Data Source:
HPRD
(in vivo)
ING1
NQO1
Description
inhibitor of growth family member 1
NAD(P)H quinone dehydrogenase 1
Image
GO Annotations
Cellular Component
Nucleus
Sin3-type Complex
Nucleus
Cytoplasm
Cytosol
Synapse
Molecular Function
Protein Binding
Zinc Ion Binding
Metal Ion Binding
Histone H3K4me3 Reader Activity
RNA Binding
NAD(P)H Dehydrogenase (quinone) Activity
Cytochrome-b5 Reductase Activity, Acting On NAD(P)H
Protein Binding
NADPH Dehydrogenase (quinone) Activity
Oxidoreductase Activity
Identical Protein Binding
NADH Dehydrogenase (quinone) (non-electrogenic) Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Chromatin Organization
Protein Import Into Nucleus
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Growth
Negative Regulation Of Cell Migration
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Programmed Cell Death
Positive Regulation Of DNA-templated Transcription
Negative Regulation Of Stem Cell Population Maintenance
Positive Regulation Of Stem Cell Population Maintenance
Protein Polyubiquitination
Ubiquinone Metabolic Process
Xenobiotic Metabolic Process
Nitric Oxide Biosynthetic Process
Response To Oxidative Stress
Synaptic Transmission, Cholinergic
Response To Toxic Substance
Removal Of Superoxide Radicals
Protein Catabolic Process
Response To Lipopolysaccharide
Cellular Response To Oxidative Stress
Negative Regulation Of Protein Catabolic Process
Vitamin E Metabolic Process
Vitamin K Metabolic Process
Innate Immune Response
Cell Redox Homeostasis
Response To Caloric Restriction
Negative Regulation Of Ferroptosis
Pathways
Regulation of ornithine decarboxylase (ODC)
NFE2L2 regulating anti-oxidant/detoxification enzymes
Drugs
Menadione
Dicoumarol
Duroquinone
3-Hydroxymethyl-5-Aziridinyl-1methyl-2-[1h-Indole-4,7-Dione]-Propanol
ES-936
Cibacron Blue
Flavin adenine dinucleotide
5-Methoxy-1,2-Dimethyl-3-(Phenoxymethyl)Indole-4,7-Dione
RH-1
Bishydroxy[2h-1-Benzopyran-2-One,1,2-Benzopyrone]
3-(HYDROXYMETHYL)-1-METHYL-5-(2-METHYLAZIRIDIN-1-YL)-2-PHENYL-1H-INDOLE-4,7-DIONE
Cannabidiol
Diseases
GWAS
Blood protein levels (
30072576
)
Erosive tooth wear (severe vs non-severe) (
29898447
)
Alcohol consumption (drinks per week) (
30679032
)
Blood osmolality (transformed sodium) (
28360221
)
Blood protein levels (
30072576
)
Body fat distribution (arm fat ratio) (
30664634
)
Body fat distribution (leg fat ratio) (
30664634
)
Body mass index (
26426971
)
Estimated glomerular filtration rate (
31015462
)
Mean platelet volume (
32888494
)
Medication use (HMG CoA reductase inhibitors) (
31015401
)
Risk-taking tendency (4-domain principal component model) (
30643258
)
Triglyceride levels (
32203549
)
Interacting Genes
29 interacting genes:
BRMS1
BRMS1L
COPS2
CYTOR
DMAP1
EP300
ESR1
EXOC4
H3C14
HDAC1
HDAC2
KAT2B
MRGBP
NQO1
PCNA
RBBP4
RBBP7
RBP1
SAP30
SFN
SIN3A
TP53
UBC
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
10 interacting genes:
CDC42
DNAJB1
GALT
HIF1A
HSPA1A
ING1
PRKN
STUB1
TP53
UBE2D1
Entrez ID
3621
1728
HPRD ID
03337
00518
Ensembl ID
ENSG00000153487
ENSG00000181019
Uniprot IDs
A0A0C4DFW2
Q9UK53
B4DLR8
P15559
PDB IDs
2QIC
1D4A
1DXO
1GG5
1H66
1H69
1KBO
1KBQ
1QBG
2F1O
3JSX
4CET
4CF6
5A4K
5EA2
5EAI
5FUQ
6FY4
6LLC
8C9J
8OK0
8PQN
8RFM
8RFN
Enriched GO Terms of Interacting Partners
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Sin3-type Complex
Negative Regulation Of Stem Cell Population Maintenance
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Stem Cell Population Maintenance
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Stem Cell Population Maintenance
Negative Regulation Of Biosynthetic Process
Histone Deacetylase Binding
Negative Regulation Of Metabolic Process
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Transcription By RNA Polymerase II
Histone Deacetylase Complex
Phosphoserine Residue Binding
Regulation Of Cellular Response To Growth Factor Stimulus
Regulation Of RNA Metabolic Process
Chromatin Organization
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
Chromatin Remodeling
Nucleus
Rhythmic Process
Regulation Of Gene Expression
Protein Sequestering Activity
NuRD Complex
Regulation Of Cell Fate Commitment
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Signal Transduction
Regulation Of Metabolic Process
Protein-containing Complex
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Negative Regulation Of Cell Migration
Cellular Response To Stress
Chromatin Binding
Regulation Of Cell Fate Specification
Negative Regulation Of Cell Motility
Negative Regulation Of Locomotion
Nucleoplasm
Enzyme Binding
Regulation Of Cellular Response To Growth Factor Stimulus
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Post-translational Protein Modification
Protein-folding Chaperone Binding
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Cellular Response To Topologically Incorrect Protein
Ubiquitin Protein Ligase Binding
Regulation Of Growth
Histone Deacetylase Binding
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Cellular Component Organization
Regulation Of Cell Growth
Enzyme Binding
Hsp70 Protein Binding
Regulation Of Mitophagy
Protein-containing Complex
Cellular Response To Heat
Regulation Of Autophagy Of Mitochondrion
Regulation Of Protein-containing Complex Assembly
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of DNA-templated Transcription
Regulation Of Macroautophagy
Regulation Of Protein Ubiquitination
Positive Regulation Of Protein-containing Complex Assembly
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cytokine-mediated Signaling Pathway
Heat Shock Protein Binding
Negative Regulation Of Apoptotic Process
Negative Regulation Of Growth
Negative Regulation Of Signal Transduction
Negative Regulation Of RNA Metabolic Process
Positive Regulation Of Response To Cytokine Stimulus
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Cellular Component Biogenesis
Response To Endoplasmic Reticulum Stress
G Protein-coupled Receptor Binding
Protein Stabilization
Regulation Of Programmed Cell Death
Regulation Of Cellular Response To Stress
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Regulation Of Signal Transduction
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Purine Nucleotide Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Response To Unfolded Protein
Response To Heat
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