ING1 and YWHAE

Number of citations: 55 (PubMedID 16581770)
Data Source: BioGRID (pull down), HPRD (in vitro)

		ING1	YWHAE
Name		inhibitor of growth family member 1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
Structure
GO Annotations	Cellular Component	Nucleus Sin3-type Complex	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Focal Adhesion Membrane Mitochondrial Membrane Melanosome Extracellular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding Histone H3K4me3 Reader Activity	RNA Binding Protein Phosphatase Inhibitor Activity Calcium Channel Regulator Activity Protein Binding Potassium Channel Regulator Activity Calcium Channel Inhibitor Activity Enzyme Binding Protein Phosphatase Binding Protein Domain Specific Binding MHC Class II Protein Complex Binding Ubiquitin Protein Ligase Binding Signaling Adaptor Activity Identical Protein Binding Histone Deacetylase Binding Transmembrane Transporter Binding Cadherin Binding Protein Heterodimerization Activity Phosphoserine Residue Binding Phosphoprotein Binding Scaffold Protein Binding Protein Sequestering Activity Molecular Function Inhibitor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Protein Import Into Nucleus Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Programmed Cell Death Positive Regulation Of DNA-templated Transcription Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance	MAPK Cascade Neuron Migration Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Heart Rate By Hormone Protein Targeting Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Transport Signal Transduction Regulation Of Mitotic Cell Cycle Intracellular Protein Localization Substantia Nigra Development Hippocampus Development Cerebral Cortex Development Intracellular Potassium Ion Homeostasis Negative Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Protein Localization To Nucleus Cellular Response To Heat Hippo Signaling Positive Regulation Of Hippo Signaling Intracellular Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Export From Nucleus Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Membrane Repolarization Protein Localization To Endoplasmic Reticulum Protein K11-linked Ubiquitination Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Calcium Ion Export Across Plasma Membrane
Pathways		None	Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane Signaling by Hippo NADE modulates death signalling Regulation of PLK1 Activity at G2/M Transition Regulation of HSF1-mediated heat shock response HSF1 activation Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex AURKA Activation by TPX2 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models RAB GEFs exchange GTP for GDP on RABs SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs		None	Fusicoccin Phenethyl Isothiocyanate
Diseases		None	Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
GWAS		Blood protein levels ( 30072576 ) Erosive tooth wear (severe vs non-severe) ( 29898447 )	Atrial fibrillation ( 30061737 ) Bevacizumab-induced composite toxicity (either hypertension or proteinuria) ( 34616010 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Left ventricular mass to end-diastolic volume ratio (MTAG) ( 33495596 ) Mean platelet volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Nicotine dependence symptom count ( 25555482 ) Reaction time ( 29844566 ) Schizophrenia ( 28991256 30285260 )
Interacting Genes		29 interacting genes: BRMS1 BRMS1L COPS2 CYTOR DMAP1 EP300 ESR1 EXOC4 H3C14 HDAC1 HDAC2 KAT2B MRGBP NQO1 PCNA RBBP4 RBBP7 RBP1 SAP30 SFN SIN3A TP53 UBC YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	148 interacting genes: ABL1 ACD AKAP13 AKAP9 ANKHD1-EIF4EBP3 ANKZF1 ARHGEF2 ARHGEF28 ATP6V0B ATXN1 BAD BCR BEX3 CALM1 CAP2 CASK CASP3 CCDC125 CCR9 CDC25A CDC25B CDK11B CDK14 CDK16 CDKN1B CEP131 CEP95 CGNL1 CHAF1A CHST11 CYSLTR2 DDX54 DISC1 DYRK1A ENKD1 EXO1 FAM13B FAM53C FGF12 FHL1 FTH1 GAPDH GPRIN2 GRAP2 GSTA1 GSTM3 GTF2B HDAC4 HDAC5 HIVEP2 HNRNPC HSF1 HSP90AA1 HSPB1 IGF1R IL7R ING1 IRAG2 IRS1 IRS2 KANK1 KCNH2 KCNK15 KCNK3 KCNK9 KIAA0232 KIF1C KLC4 KRT18 LCOR LCP2 MAGEB4 MAP3K10 MAP3K2 MAP3K3 MAP3K5 MAPK7 MARK2P21 MCM10 MDM4 METAP2 MSL2 MST1R MT-CO2 MYH10 NAF1 NCAM2 NCOR2 NDEL1 NEDD4L NIN PAPOLA PARD3B PIMREG PNLIP POT1 PRC1 PRDX6 PRKCG RAB11FIP2 RAF1 RAP1GAP2 RASAL3 RASGRF1 RBIS RBM14 REM1 RGS3 RIN1 RIPK2 RPA2 RPGR RXFP3 SAMSN1 SLC8A1 SLC8A2 SLC8A3 SMAGP SNAPIN SNCA SNF8 SORBS2 SRC SYN2 TAF7 TAFAZZIN TBC1D3F TBP TCEANC TFDP2 TGFB1 TLK1 TNFAIP3 TOP2A TSC1 TSC2 TTC3 UBE3A USP43 VIM WNK1 WWTR1 YWHAB YWHAG YWHAH YWHAZ ZC3HC1 ZNF839
Entrez ID		3621	7531
HPRD ID		03337	05457
Ensembl ID		ENSG00000153487	ENSG00000108953
Uniprot IDs		A0A0C4DFW2 Q9UK53	P62258 V9HW98
PDB IDs		2QIC	2BR9 3UAL 3UBW 6EIH 7C8E 7V9B 8DGM 8DGN 8DGP 8DP5 8Q1S
GO Terms Enriched among Interactors		Sin3-type Complex Negative Regulation Of Stem Cell Population Maintenance Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Stem Cell Population Maintenance Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Stem Cell Population Maintenance Negative Regulation Of Biosynthetic Process Histone Deacetylase Binding Negative Regulation Of Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transcription By RNA Polymerase II Histone Deacetylase Complex Phosphoserine Residue Binding Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of RNA Metabolic Process Chromatin Organization Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Chromatin Remodeling Nucleus Rhythmic Process Regulation Of Gene Expression Protein Sequestering Activity NuRD Complex Regulation Of Cell Fate Commitment Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Signal Transduction Regulation Of Metabolic Process Protein-containing Complex Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Cell Migration Cellular Response To Stress Chromatin Binding Regulation Of Cell Fate Specification Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Nucleoplasm Enzyme Binding	Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Signaling Identical Protein Binding Regulation Of Signal Transduction Regulation Of Protein Modification Process Regulation Of Biological Quality Transmembrane Transporter Binding Positive Regulation Of Metabolic Process Cytoplasm Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Negative Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Membrane Potential Cytosol Negative Regulation Of Signal Transduction Kinase Activity Negative Regulation Of Signaling Negative Regulation Of Cell Communication Signal Transduction MAPK Cascade Nucleus Regulation Of Rho Protein Signal Transduction Intracellular Signaling Cassette MAP Kinase Kinase Kinase Activity Regulation Of Catalytic Activity Cellular Response To Hydrogen Peroxide Protein Kinase Binding Axon Postsynaptic Density Calcium:sodium Antiporter Activity Response To Hydrogen Peroxide Protein-containing Complex Protein Kinase C Binding Cellular Response To Chemical Stress Protein Domain Specific Binding Regulation Of Primary Metabolic Process Cellular Response To Reactive Oxygen Species Positive Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Insulin-like Growth Factor Receptor Signaling Pathway Transferase Activity Enzyme Binding Perinuclear Region Of Cytoplasm