IMPDH2 and ALS2

		IMPDH2	ALS2
Description		inosine monophosphate dehydrogenase 2	alsin Rho guanine nucleotide exchange factor ALS2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Peroxisomal Membrane Cytosol Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Ruffle Nucleus Cytoplasm Early Endosome Centrosome Cytosol Postsynaptic Density Lamellipodium Dendrite Growth Cone Vesicle Protein-containing Complex Dendritic Spine Intracellular Membrane-bounded Organelle Glutamatergic Synapse
	Molecular Function	Nucleotide Binding DNA Binding RNA Binding Catalytic Activity IMP Dehydrogenase Activity Protein Binding Oxidoreductase Activity Metal Ion Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity
	Biological Process	Purine Nucleotide Biosynthetic Process GMP Biosynthetic Process GTP Biosynthetic Process Circadian Rhythm Lymphocyte Proliferation Cellular Response To Interleukin-4 'de Novo' XMP Biosynthetic Process	Behavioral Fear Response Receptor Recycling Response To Oxidative Stress Endosome Organization Lysosomal Transport Neuromuscular Junction Development Locomotory Behavior Intracellular Protein Localization Vesicle Organization Endosomal Transport Positive Regulation Of Rac Protein Signal Transduction Synaptic Transmission, Glutamatergic Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Neuron Projection Morphogenesis Regulation Of Endosome Size Protein Homooligomerization Regulation Of Biological Quality Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Pathways		Neutrophil degranulation Purine ribonucleoside monophosphate biosynthesis Potential therapeutics for SARS Azathioprine ADME	RAB GEFs exchange GTP for GDP on RABs RAC1 GTPase cycle
Drugs		NADH Mycophenolate mofetil Ribavirin Mycophenolic acid Mercaptopurine Selenazole-4-carboxyamide-adenine dinucleotide 6-Chloropurine Riboside, 5'-Monophosphate Inosinic Acid VX-148
Diseases			Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Juvenile primary lateral sclerosis
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Perceived intensity of neohesperidin dihydrochalcone ( 31005972) Perceived intensity of sweet substances ( 31005972)
Interacting Genes		17 interacting genes: AGR2 AKT1 APIP CEBPA CLK1 CPLANE2 FXR1 FXR2 IL1F10 OGT PIAS4 POU6F2 STAT3 SUMO2 SUMO4 TRAF2 UBQLN4	1 interacting genes: YWHAB
Entrez ID		3615	57679
HPRD ID		00895	05893
Ensembl ID		ENSG00000178035	ENSG00000003393
Uniprot IDs		A0A7I2YQK5 E7ETK5 H0Y4R1 P12268	A0A7P0T8F3 A0A7P0Z4I4 A8K4R4 Q96Q42
PDB IDs		1B3O 1NF7 1NFB 6I0M 6I0O 6U8E 6U8N 6U8R 6U8S 6U9O 6UA2 6UA4 6UA5 6UAJ 6UC2 6UDO 6UDP 6UDQ 8FOZ 8FUZ 8G8F 8G9B 9DMU
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Metabolic Process Regulation Of MRNA Stability Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Post-transcriptional Regulation Of Gene Expression Regulation Of MRNA Metabolic Process Regulation Of RNA Stability Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process TORC1 Signaling Positive Regulation Of Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Translation Identical Protein Binding Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process TOR Signaling Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Primary Metabolic Process Carbohydrate Homeostasis Glucose Homeostasis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Protein Homodimerization Activity Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cellular Response To Stress Positive Regulation Of Gene Expression Inflammatory Response Negative Regulation Of Double-strand Break Repair Positive Regulation Of MRNA Catabolic Process Regulation Of Protein Catabolic Process Protein-containing Complex Negative Regulation Of Catabolic Process Negative Regulation Of DNA Repair Glutamatergic Synapse Negative Regulation Of Translational Initiation Cytokine-mediated Signaling Pathway Regulation Of Translation Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA Recombination Positive Regulation Of Long-term Neuronal Synaptic Plasticity Protein Sumoylation Defense Response Positive Regulation Of MRNA Metabolic Process	IMP Dehydrogenase Activity Nuclear Migration Along Microfilament Nuclear Migration Along Microtubule Nuclear Matrix Organization Nucleokinesis Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Nuclear Matrix Anchoring At Nuclear Membrane GTP Biosynthetic Process 'de Novo' XMP Biosynthetic Process Phosphoserine Residue Binding Cytoskeleton-nuclear Membrane Anchor Activity Meiotic Nuclear Membrane Microtubule Tethering Complex
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