ALS2

Gene Name		amyotrophic lateral sclerosis 2 (juvenile)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Early Endosome Centrosome Cytosol Postsynaptic Density Lamellipodium Dendrite Growth Cone Vesicle Dendritic Spine Protein Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Ran Guanyl-nucleotide Exchange Factor Activity Protein Binding Rab Guanyl-nucleotide Exchange Factor Activity Rab GTPase Binding Rac Guanyl-nucleotide Exchange Factor Activity Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity
	Biological Process	Behavioral Fear Response Receptor Recycling Response To Oxidative Stress Endosome Organization Neuromuscular Junction Development Locomotory Behavior Protein Localization Vesicle Organization Endosomal Transport Positive Regulation Of Rab GTPase Activity Positive Regulation Of Ran GTPase Activity Positive Regulation Of Rac GTPase Activity Positive Regulation Of Rac Protein Signal Transduction Synaptic Transmission, Glutamatergic Positive Regulation Of Protein Kinase Activity Neuron Projection Morphogenesis Regulation Of Endosome Size Positive Regulation Of Protein Serine/threonine Kinase Activity
Pathways
Drugs
Diseases
GWAS
Protein-protein Interactions		1 interactors: YWHAB
Entrez ID		57679
HPRD ID		05893
Ensembl ID		ENSG00000003393
Uniprot IDs		A8K4R4 Q96Q42
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Protein Dephosphorylation Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Cytoplasmic Sequestering Of Protein Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Hippo Signaling Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Activation Of MAPKK Activity Negative Regulation Of Dephosphorylation
Tagcloud ?		c147r causative chmp2b dao dctn1 diagnose f21c faces fig4 g148d g59r got haloplex optn pedigree pfn1 probands sanger segregate setx sigmar1 sod1 spg11 sqstm1 synonymous tardbp ubqln2 vapb vcp