AQP4 and AP2M1

Number of citations of the paper that reports this interaction (PubMedID 11742978)
52

Data Source:
HPRD (in vitro)

		AQP4	AP2M1
Description		aquaporin 4	adaptor related protein complex 2 subunit mu 1
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Endosome Plasma Membrane External Side Of Plasma Membrane Endosome Membrane Membrane Basolateral Plasma Membrane Sarcolemma Cell Projection Astrocyte End-foot	Lysosomal Membrane Cytosol Plasma Membrane Clathrin-coated Pit Synaptic Vesicle Cytoplasmic Side Of Plasma Membrane Membrane AP-2 Adaptor Complex Clathrin Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Endolysosome Membrane Synapse Clathrin-coated Endocytic Vesicle Extracellular Exosome Postsynapse Extrinsic Component Of Presynaptic Endocytic Zone Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding Water Channel Activity Channel Activity Identical Protein Binding	Signal Sequence Binding Protein Binding Lipid Binding Clathrin Adaptor Activity Transmembrane Transporter Binding Low-density Lipoprotein Particle Receptor Binding Disordered Domain Specific Binding
	Biological Process	Renal Water Homeostasis Water Transport Intracellular Water Homeostasis Multicellular Organismal-level Water Homeostasis Protein Homotetramerization Transmembrane Transport Cellular Response To Type II Interferon Cerebrospinal Fluid Circulation	Positive Regulation Of Receptor Internalization Intracellular Protein Transport Endocytosis Vesicle Budding From Membrane Protein Transport Vesicle-mediated Transport Receptor Internalization Synaptic Vesicle Endocytosis Protein-containing Complex Assembly Clathrin-dependent Endocytosis Regulation Of Vesicle Size Postsynaptic Neurotransmitter Receptor Internalization Vesicle-mediated Transport In Synapse Positive Regulation Of Synaptic Vesicle Endocytosis Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins	Nef mediated downregulation of CD28 cell surface expression Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 31152163) Chronic kidney disease ( 31152163) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 30604766 31152163) Glomerular filtration rate ( 29403010) Metabolite levels ( 23823483)	Major depressive disorder ( 22472876)
Interacting Genes		7 interacting genes: AP2M1 AP3M1 CREB3 CSNK2A1 CSNK2A2 GJA8 HPCAL4	86 interacting genes: ADRA1B AGTR1 AP2B1 AQP4 ARRB2 ATG9A ATXN1L BDKRB2 C1orf35 CACNA1A CD22 CD2BP2 CD3D CDK11B CEBPA CLK2 CORO7 CSNK2B CTLA4 CXorf51A CXorf51B DAB2 DCX DPPA2 DVL2 EAF1 EHD2 EIF1AD FAM90A1 FURIN FXR2 GAK GRIN2A GRIN2B H2BC10 H2BC13 H2BC21 H2BC4 H2BC6 H2BC7 H2BC8 HEXIM2 HOOK2 HTR6 IKZF1 IRS2 KCNJ11 KNOP1 LAMP1 LTB4R2 LUC7L2 LY9 MAB21L3 MED4 MEGF10 MFAP1 MPP1 MTURN NAA11 NCOR2 NDRG1 NKAPD1 PRPF18 PRPF38A PRR13 PTS RALBP1 RNF111 RPL22 RPL38 RRP12 RSPH14 RUNDC3A SFRP4 SNCA SPATS2 STON2 SYNJ1 TASOR TBC1D5 TGOLN2 TIAM1 TMA16 UBC ZBTB8A ZNF581
Entrez ID		361	1173
HPRD ID		02631	03014
Ensembl ID		ENSG00000171885	ENSG00000161203
Uniprot IDs		A0A5F9ZHR4 F1DSG4 P55087 V9PBN7	B4DNB9 E9PFW3 Q96CW1
PDB IDs		3GD8 8V8S 8V91 8V9D	1H6E 6BNT 6URI
Enriched GO Terms of Interacting Partners?		Protein Kinase CK2 Complex Postsynaptic Neurotransmitter Receptor Internalization Clathrin Adaptor Complex PcG Protein Complex Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Vacuole Receptor Internalization Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Establishment Of Protein Localization To Vacuole Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Chromosome Separation Positive Regulation Of Deacetylase Activity Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Vesicle-mediated Transport In Synapse Protein Localization To Vacuole Intracellular Protein Transport Negative Regulation Of Protein Catabolic Process Regulation Of Chromosome Segregation Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Signal Sequence Binding Receptor-mediated Endocytosis Extrinsic Component Of Presynaptic Endocytic Zone Membrane Regulation Of Ubiquitin-dependent Protein Catabolic Process Vacuolar Transport Positive Regulation Of Aggrephagy Release From Viral Latency Positive Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Synaptic Vesicle Recycling Protein Targeting Regulation Of Proteasomal Protein Catabolic Process Regulation Of Macroautophagy Gap Junction-mediated Intercellular Transport CCR1 Chemokine Receptor Binding Postsynaptic Recycling Endosome Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Double-strand Break Repair Negative Regulation Of Apoptotic Process Intercellular Transport CAMP Response Element Binding Protein Binding AP-2 Adaptor Complex Double-strand Break Repair Via Classical Nonhomologous End Joining Negative Regulation Of Programmed Cell Death AP-3 Adaptor Complex Wnt Signaling Pathway Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA	Innate Immune Response In Mucosa Mucosal Immune Response Organ Or Tissue Specific Immune Response Protein-containing Complex Organization Protein-containing Complex Assembly Protein Heterodimerization Activity Structural Constituent Of Chromatin Antibacterial Humoral Response Nucleosome Assembly Protein Domain Specific Binding Nucleosome Nucleosome Organization Protein-DNA Complex Assembly AP-2 Adaptor Complex Import Into Cell Endocytosis Receptor-mediated Endocytosis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Defense Response To Gram-positive Bacterium Synaptic Vesicle Endocytosis Synaptic Vesicle Uncoating Presynaptic Endocytosis Trans-synaptic Signaling Clathrin Adaptor Activity Synaptic Signaling Clathrin Coat Assembly Nucleoplasm Positive Regulation Of Receptor-mediated Endocytosis Clathrin-coated Endocytic Vesicle Antimicrobial Humoral Response Positive Regulation Of Endocytosis Clathrin Coat Disassembly Regulation Of Neuronal Synaptic Plasticity Regulation Of Endocytosis Chemical Synaptic Transmission Excitatory Postsynaptic Potential Regulation Of Presynapse Assembly Regulation Of Presynapse Organization Vesicle Uncoating Nucleus Positive Regulation Of Receptor Internalization Synaptic Membrane Protein Binding Cellular Component Assembly NMDA Glutamate Receptor Activity Synapse Clathrin-dependent Endocytosis Synaptic Vesicle Regulation Of Vesicle-mediated Transport NMDA Selective Glutamate Receptor Complex
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