IL17A and IL17RA

Number of citations: 0 (PubMedID 9367539)
Data Source: HPRD (in vitro, in vivo)

		IL17A	IL17RA
Name		interleukin 17A	interleukin 17 receptor A
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space External Side Of Plasma Membrane	Extracellular Region Plasma Membrane Membrane
	Molecular Function	Cytokine Activity Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Signaling Receptor Binding Protein Binding Interleukin-17 Receptor Activity
	Biological Process	Positive Regulation Of Antimicrobial Peptide Production Adaptive Immune Response Immune System Process Apoptotic Process Inflammatory Response Immune Response Notch Signaling Pathway Cell-cell Signaling Cell Death Response To Wounding Gene Expression Positive Regulation Of Keratinocyte Proliferation Keratinocyte Differentiation Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-16 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Interleukin-17A-mediated Signaling Pathway Keratinocyte Proliferation Innate Immune Response Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Intestinal Epithelial Structure Maintenance Cellular Response To Interleukin-1 Fibroblast Activation Regulation Of Primary Metabolic Process Interleukin-17-mediated Signaling Pathway Granulocyte Migration Negative Regulation Of Inflammatory Response To Wounding Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Bicellular Tight Junction Assembly Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Negative Regulation Of Interleukin-17-mediated Signaling Pathway Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production	Adaptive Immune Response Immune System Process Inflammatory Response Cell Surface Receptor Signaling Pathway Response To Virus Protein Catabolic Process Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-5 Production Positive Regulation Of Interleukin-6 Production Interleukin-17A-mediated Signaling Pathway Innate Immune Response Positive Regulation Of Inflammatory Response Defense Response To Fungus Granulocyte Chemotaxis Fibroblast Activation T-helper 17 Type Immune Response Interleukin-17-mediated Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production
Pathways		Interleukin-17 signaling Interleukin-4 and Interleukin-13 signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses	Interleukin-17 signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs		Secukinumab Ixekizumab Bimekizumab	None
Diseases		None	Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
GWAS		Height ( 28552196 )	Blood protein levels ( 30072576 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Granulocyte percentage of myeloid white cells ( 27863252 ) Heschl's gyrus morphology ( 25130324 ) Lymphocyte percentage of white cells ( 32888494 ) Monocyte count ( 27863252 32888494 ) Monocyte percentage of white cells ( 27863252 32888494 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 32888494 ) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600 ) White blood cell count ( 27863252 32888494 )
Novel Interactors		None recorded	5 novel interactors: BCL2L13 BID POTEH PTPRT TESK1
Interacting Genes		3 interacting genes: DPH2 IL17RA KCNIP4	2 interacting genes: IL17A MTDH
Entrez ID		3605	23765
HPRD ID		04396	10399
Ensembl ID		ENSG00000112115	ENSG00000177663
Uniprot IDs		Q16552	Q96F46
PDB IDs		2VXS 4HR9 4HSA 4QHU 5HHV 5HHX 5HI3 5HI4 5HI5 5N7W 5N92 5NAN 5VB9 6WIO 6WIR 7AMA 7AMG 7UWM 7UWN 7WKX 7Z2M 7ZAN 8B7W 8CDG 8DY1 8DY5 8DYF 8DYG 8DYH 8DYI 8USR 8USS 9FKX 9FL3 9H4D 9H4O	3JVF 4HSA 4NUX 5N9B 5NAN 7UWL 7UWM 7UWN 7ZAN
GO Terms Enriched among Interactors		2-(3-amino-3-carboxypropyl)histidine Synthase Complex Protein Histidyl Modification To Diphthamide 2-(3-amino-3-carboxypropyl)histidine Synthase Activity Fibroblast Activation Positive Regulation Of Interleukin-23 Production Interleukin-17 Receptor Activity T-helper 17 Type Immune Response Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Interleukin-17A-mediated Signaling Pathway Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Regulation Of Interleukin-23 Production Interleukin-17-mediated Signaling Pathway Positive Regulation Of Interleukin-5 Production Positive Regulation Of Interleukin-13 Production Regulation Of Interleukin-5 Production Positive Regulation Of Cytokine Production Involved In Inflammatory Response	None