IL17A and KCNIP4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		IL17A	KCNIP4
Description		interleukin 17A	potassium voltage-gated channel interacting protein 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space External Side Of Plasma Membrane	Cytoplasm Peroxisome Endoplasmic Reticulum Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Monoatomic Ion Channel Complex
	Molecular Function	Cytokine Activity Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Potassium Channel Activity Calcium Ion Binding Protein Binding Potassium Channel Regulator Activity Metal Ion Binding
	Biological Process	Positive Regulation Of Antimicrobial Peptide Production Adaptive Immune Response Immune System Process Apoptotic Process Inflammatory Response Immune Response Notch Signaling Pathway Cell-cell Signaling Cell Death Response To Wounding Gene Expression Positive Regulation Of Keratinocyte Proliferation Keratinocyte Differentiation Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-16 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Interleukin-17A-mediated Signaling Pathway Keratinocyte Proliferation Innate Immune Response Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Intestinal Epithelial Structure Maintenance Cellular Response To Interleukin-1 Fibroblast Activation Regulation Of Primary Metabolic Process Interleukin-17-mediated Signaling Pathway Granulocyte Migration Negative Regulation Of Inflammatory Response To Wounding Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Bicellular Tight Junction Assembly Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Negative Regulation Of Interleukin-17-mediated Signaling Pathway Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production	Monoatomic Ion Transport Potassium Ion Transport Regulation Of Signal Transduction Monoatomic Ion Transmembrane Transport Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport
Pathways		Interleukin-17 signaling Interleukin-4 and Interleukin-13 signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses	Phase 1 - inactivation of fast Na+ channels
Drugs		Secukinumab Ixekizumab Bimekizumab
Diseases
GWAS		Height ( 28552196)	Appendicular lean mass ( 33097823) Cadmium levels ( 26025379) Colorectal cancer ( 29228715) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 26169577) Diverticular disease ( 30177863) Lingual gyrus volume ( 31530798) Obesity-related traits ( 23251661) Parkinson disease and lewy body pathology ( 25663231) Post bronchodilator FEV1/FVC ratio ( 26634245) Postburn scar height ( 30595539) Rheumatoid arthritis ( 21156761) Suicidal ideation ( 20877300)
Interacting Genes		3 interacting genes: DPH2 IL17RA KCNIP4	11 interacting genes: APP ASPH COL1A2 GOLGA7 IL17A KCND2 LITAF MEOX2 PSEN1 PSEN2 TRH
Entrez ID		3605	80333
HPRD ID		04396	12184
Ensembl ID		ENSG00000112115	ENSG00000185774
Uniprot IDs		Q16552	A8K4N3 Q3YAB7 Q6PIL6
PDB IDs		2VXS 4HR9 4HSA 4QHU 5HHV 5HHX 5HI3 5HI4 5HI5 5N7W 5N92 5NAN 5VB9 6WIO 6WIR 7AMA 7AMG 7UWM 7UWN 7WKX 7Z2M 7ZAN 8B7W 8CDG 8DY1 8DY5 8DYF 8DYG 8DYH 8DYI 8USR 8USS 9FKX 9FL3 9H4D 9H4O
Enriched GO Terms of Interacting Partners?		2-(3-amino-3-carboxypropyl)histidine Synthase Complex Protein Histidyl Modification To Diphthamide 2-(3-amino-3-carboxypropyl)histidine Synthase Activity Fibroblast Activation Positive Regulation Of Interleukin-23 Production Interleukin-17 Receptor Activity T-helper 17 Type Immune Response Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Interleukin-17A-mediated Signaling Pathway Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Regulation Of Interleukin-23 Production Interleukin-17-mediated Signaling Pathway Positive Regulation Of Interleukin-5 Production Positive Regulation Of Interleukin-13 Production Regulation Of Interleukin-5 Production Positive Regulation Of Cytokine Production Involved In Inflammatory Response	Notch Signaling Pathway Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Astrocyte Activation Involved In Immune Response Aspartic Endopeptidase Activity, Intramembrane Cleaving Synaptic Membrane Gamma-secretase Complex Positive Regulation Of Protein Transport Notch Receptor Processing Amyloid-beta Formation Neuron Projection Maintenance Skin Morphogenesis Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Protein Trimerization Amyloid Precursor Protein Catabolic Process Regulation Of Amyloid Fibril Formation Astrocyte Activation Regulation Of Calcium Ion Transmembrane Transport Inorganic Ion Homeostasis Positive Regulation Of Glycolytic Process Membrane Protein Ectodomain Proteolysis Amyloid-beta Metabolic Process Positive Regulation Of Amino Acid Transport Amyloid Precursor Protein Metabolic Process Regulation Of Protein Transport Positive Regulation Of Protein Localization Regulation Of Tumor Necrosis Factor Production Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Positive Regulation Of Proteolysis Positive Regulation Of RNA Biosynthetic Process Regulation Of Establishment Of Protein Localization Early Endosome Membrane Positive Regulation Of ATP Metabolic Process Locomotory Behavior Positive Regulation Of DNA-templated Transcription Membrane Protein Proteolysis Dendritic Shaft Calcium Ion Homeostasis Neuron Projection Organization Regulation Of Biological Quality Regulation Of Calcium Ion Transport Positive Regulation Of RNA Metabolic Process Cell-cell Signaling Protein Complex Oligomerization Regulation Of Blood Circulation Cellular Response To Amyloid-beta Signaling
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