IL17A and DPH2

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		IL17A	DPH2
Name		interleukin 17A	diphthamide biosynthesis 2
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space External Side Of Plasma Membrane	Cytosol Protein-containing Complex 2-(3-amino-3-carboxypropyl)histidine Synthase Complex
	Molecular Function	Cytokine Activity Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Protein Binding Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding 2-(3-amino-3-carboxypropyl)histidine Synthase Activity
	Biological Process	Positive Regulation Of Antimicrobial Peptide Production Adaptive Immune Response Immune System Process Apoptotic Process Inflammatory Response Immune Response Notch Signaling Pathway Cell-cell Signaling Cell Death Response To Wounding Gene Expression Positive Regulation Of Keratinocyte Proliferation Keratinocyte Differentiation Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-16 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Interleukin-17A-mediated Signaling Pathway Keratinocyte Proliferation Innate Immune Response Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Intestinal Epithelial Structure Maintenance Cellular Response To Interleukin-1 Fibroblast Activation Regulation Of Primary Metabolic Process Interleukin-17-mediated Signaling Pathway Granulocyte Migration Negative Regulation Of Inflammatory Response To Wounding Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Bicellular Tight Junction Assembly Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Negative Regulation Of Interleukin-17-mediated Signaling Pathway Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production	Protein Histidyl Modification To Diphthamide
Pathways		Interleukin-17 signaling Interleukin-4 and Interleukin-13 signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses	Synthesis of diphthamide-EEF2
Drugs		Secukinumab Ixekizumab Bimekizumab	None
GWAS		Height ( 28552196 )	Autism spectrum disorder or schizophrenia ( 28540026 )
Novel Interactors		None recorded	1 novel interactors: BEST4
Interacting Genes		3 interacting genes: DPH2 IL17RA KCNIP4	7 interacting genes: CRYGA FARS2 IL17A MAGOH MISP NEK6 TNK2
Entrez ID		3605	1802
HPRD ID		04396	16023
Ensembl ID		ENSG00000112115	ENSG00000132768
Uniprot IDs		Q16552	B3KRB8 Q9BQC3
PDB IDs		2VXS 4HR9 4HSA 4QHU 5HHV 5HHX 5HI3 5HI4 5HI5 5N7W 5N92 5NAN 5VB9 6WIO 6WIR 7AMA 7AMG 7UWM 7UWN 7WKX 7Z2M 7ZAN 8B7W 8CDG 8DY1 8DY5 8DYF 8DYG 8DYH 8DYI 8USR 8USS 9FKX 9FL3 9H4D 9H4O	Not available
GO Terms Enriched among Interactors		2-(3-amino-3-carboxypropyl)histidine Synthase Complex Protein Histidyl Modification To Diphthamide 2-(3-amino-3-carboxypropyl)histidine Synthase Activity Fibroblast Activation Positive Regulation Of Interleukin-23 Production Interleukin-17 Receptor Activity T-helper 17 Type Immune Response Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Interleukin-17A-mediated Signaling Pathway Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Regulation Of Interleukin-23 Production Interleukin-17-mediated Signaling Pathway Positive Regulation Of Interleukin-5 Production Positive Regulation Of Interleukin-13 Production Regulation Of Interleukin-5 Production Positive Regulation Of Cytokine Production Involved In Inflammatory Response	None