HECTD1 and IGSF1

Number of citations of the paper that reports this interaction (PMID 12421765)
28

Data Source:
HPRD (two hybrid)

		HECTD1	IGSF1
Gene Name		HECT domain containing E3 ubiquitin protein ligase 1	immunoglobulin superfamily, member 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Extracellular Region Membrane Integral Component Of Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity Metal Ion Binding	Receptor Activity Protein Binding Coreceptor Activity Inhibin Binding
	Biological Process	Neural Tube Closure Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Regulation Of Transcription, DNA-templated Signal Transduction
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: IGSF1 YWHAG	8 interactors: ACVR1 ACVR1B ACVR2A ACVR2B HECTD1 IGF1 INHBB RANBP10
Entrez ID		25831	3547
HPRD ID		17098	02138
Ensembl ID		ENSG00000092148	ENSG00000147255
Uniprot IDs		Q9ULT8	Q8N6C5
PDB IDs		2DK3 2LC3 3DKM
Enriched GO Terms of Interacting Partners?			Activin Receptor Signaling Pathway Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Activin Receptor Signaling Pathway Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Positive Regulation Of Protein Phosphorylation Regulation Of Osteoblast Differentiation Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Positive Regulation Of Bone Mineralization Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Biomineral Tissue Development Regulation Of Ossification Positive Regulation Of Protein Metabolic Process Gastrulation With Mouth Forming Second Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Signal Transduction By Phosphorylation Developmental Process Involved In Reproduction Regulation Of Phosphorus Metabolic Process Regulation Of Bone Mineralization BMP Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Cell Differentiation Tissue Development Regulation Of Signaling Determination Of Left/right Symmetry Determination Of Bilateral Symmetry Tube Morphogenesis Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Epithelium Development Mesoderm Development Embryo Development Regulation Of Protein Metabolic Process Positive Regulation Of Erythrocyte Differentiation Reproductive Process Gastrulation Embryonic Morphogenesis System Development Positive Regulation Of Cellular Metabolic Process Tube Development Development Of Primary Sexual Characteristics Regulation Of Cell Differentiation Regulation Of Erythrocyte Differentiation
Tagcloud ?		adenomatous apc augmented axin chains ck1alpha confers conjugated destruction diminished disrupted e3 earmarking effector foster gsk3beta ligase lys modifies polyposis polyubiquitin polyubiquitylation promotes proteasomal stabilization ubiquitin ubiquitylation wnt wnt3a	boys ch congenital definitive exome greatly harbored heterozygous hypothyroidism japanese lacks missense mothers nonsense prolactin q645x r1189x sequencing severely stature superfamily t3 t4 thereafter thrive traffic unexplained v1082e
Tagcloud (Difference) ?		adenomatous apc augmented axin chains ck1alpha confers conjugated destruction diminished disrupted e3 earmarking effector foster gsk3beta ligase lys modifies polyposis polyubiquitin polyubiquitylation promotes proteasomal stabilization ubiquitin ubiquitylation wnt wnt3a	boys ch congenital definitive exome greatly harbored heterozygous hypothyroidism japanese lacks missense mothers nonsense prolactin q645x r1189x sequencing severely stature superfamily t3 t4 thereafter thrive traffic unexplained v1082e
Tagcloud (Intersection) ?