HECTD1

Description		HECT domain E3 ubiquitin protein ligase 1
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GO Annotations	Cellular Component
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Heart Valve Development Ventricular Septum Development Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Aorta Development
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Novel Interacting Genes		2 novel interacting genes: KHNYN SCFD1
Interacting Genes		9 interacting genes: HRAS IGSF1 MTNR1B NRIP1 UBE2D1 UBE2D2 UBE2D3 UBE2L3 YWHAG
Entrez ID		25831
HPRD ID		17098
Ensembl ID		ENSG00000092148
Uniprot IDs		A0A087X2H1 A0A8I5QJU2 H0YJD4 Q9ULT8
PDB IDs		2DK3 2LC3 3DKM
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Regulation Of Establishment Of Protein Localization Regulation Of Protein Localization Modification-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein K48-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein K6-linked Ubiquitination Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Macromolecule Catabolic Process Protein K11-linked Ubiquitination Regulation Of Protein Targeting To Mitochondrion Proteolysis Ovarian Follicle Rupture Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway TORC1 Signaling Negative Regulation Of TORC1 Signaling Negative Regulation Of BMP Signaling Pathway Protein Autoubiquitination Positive Regulation Of Establishment Of Protein Localization Negative Regulation Of Signal Transduction GTPase Complex Activin Receptor Antagonist Activity Ubiquitin Protein Ligase Activity TOR Signaling Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of TOR Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of TORC1 Signaling Phospholipase C Activator Activity Protein Kinase C Inhibitor Activity Positive Regulation Of Protein Ubiquitination Protein Modification Process Regulation Of BMP Signaling Pathway Inhibin Binding Melatonin Receptor Activity Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Nucleotide Binding Negative Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Post-translational Protein Modification Proteasomal Protein Catabolic Process Regulation Of Neuronal Action Potential
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