LCE2A and ECM1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LCE2A	ECM1
Description		late cornified envelope 2A	extracellular matrix protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Extracellular Region Extracellular Space Extracellular Matrix Platelet Dense Granule Lumen Extracellular Exosome
	Molecular Function	Protein Binding	Protease Binding Interleukin-2 Receptor Binding Extracellular Matrix Structural Constituent Protein Binding
	Biological Process	Epidermis Development Keratinization	Ossification Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Negative Regulation Of Cytokine-mediated Signaling Pathway Chondrocyte Development Regulation Of Type 2 Immune Response Endochondral Bone Growth Regulation Of Transcription By RNA Polymerase II Inflammatory Response Signal Transduction Negative Regulation Of Peptidase Activity Regulation Of Bone Mineralization Negative Regulation Of Bone Mineralization Biomineral Tissue Development Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Angiogenesis Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of T Cell Migration
Pathways		Formation of the cornified envelope	Platelet degranulation
Drugs
Diseases			Lipoid proteinosis; Urbach-Wiethe disease
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Migraine ( 27322543) Refractive error ( 32231278) Schizophrenia ( 28991256 30285260) Spontaneous coronary artery dissection ( 32374345 32887874) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		67 interacting genes: ADAMTSL4 CRCT1 CREB5 CYSRT1 ECM1 GUCD1 HOXA1 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP2-3 KRTAP2-4 KRTAP21-2 KRTAP3-2 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1F LCE2B LCE2C LCE2D LCE3A LCE3B LCE3D LCE3E LCE4A LCE5A MEOX2 NBPF19 NOTCH2NLA OTX1 PLA2G10 RGS17 RGS20 SPRY1 SUMO1P1 TRIM42 VASN	39 interacting genes: A1CF ACTN3 AIRIM ATN1 BCAS2 BNIP3L CPTP CYSRT1 DDIAS DTX2 ENKD1 FASLG FBLN1 FKBP6 FRS3 FXR1 GCM2 GNE GPANK1 GRN HOXC8 HSPG2 IRAK3 ITGB4 KLHL38 KRTAP5-3 KRTAP9-3 LCE2A LIN7A LMO4 MKRN3 PRKAR2B RERE SAMD11 SGTB SNRPC SRPK1 UBQLN1 UBQLN2
Entrez ID		353139	1893
HPRD ID		13971	03727
Ensembl ID		ENSG00000187173	ENSG00000143369
Uniprot IDs		Q5TA79	A0A140VJI7 Q16610
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Keratinization Epidermis Development Tissue Development Hair Cycle Identical Protein Binding Cytosol Protein Binding	Embryo Implantation
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