CBX2 and KRTAP4-4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CBX2	KRTAP4-4
Description		chromobox 2	keratin associated protein 4-4
Image			No pdb structure
GO Annotations	Cellular Component	Euchromatin Heterochromatin Nucleus Nucleoplasm Chromosome PcG Protein Complex PRC1 Complex	Cytosol Intermediate Filament Keratin Filament
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Histone H3K9me2/3 Reader Activity	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Sex Differentiation Cell Differentiation Development Of Primary Sexual Characteristics	Hair Cycle
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription	Keratinization
Drugs
Diseases		46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS		Brain morphology (MOSTest) ( 32665545)
Interacting Genes		25 interacting genes: BOLL CYSRT1 DHX57 H3-3A H3-4 H3C1 H3C14 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP2-4 KRTAP4-12 KRTAP4-4 MDFI MEOX2 RBMY1A1 RBMY1F RBMY1J RBPMS2 RYBP TRIM55 TRIM63	80 interacting genes: ADAMTSL4 ALX1 AQP1 BAG4 CATSPER1 CBX2 CRCT1 CREB5 CYSRT1 GLRX3 GNE HEY2 HOXA1 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-3 KRTAP13-2 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP26-1 KRTAP3-2 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A MEOX2 NBPF19 NOTCH2NLA NPDC1 NR4A3 NUFIP2 OTX1 POU4F2 SHFL SMCP TNS2 TRIM42 VASN ZNF440 ZNF497 ZNF764
Entrez ID		84733	84616
HPRD ID		14397	13945
Ensembl ID		ENSG00000173894	ENSG00000171396
Uniprot IDs		Q14781	Q9BYR3
PDB IDs		2D9U 3H91 5EPK
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Structural Constituent Of Chromatin Positive Regulation Of MRNA Splicing, Via Spliceosome Nucleic Acid Binding Nucleosome Assembly Regulation Of MRNA Splicing, Via Spliceosome Nucleosome Positive Regulation Of RNA Splicing Nucleosome Organization Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process Regulation Of RNA Splicing Protein-DNA Complex Assembly Hair Cycle Identical Protein Binding Positive Regulation Of MRNA Metabolic Process Protein Heterodimerization Activity Chromatin Remodeling Spliceosomal Complex	Intermediate Filament Keratin Filament Keratinization Epidermis Development Tissue Development Identical Protein Binding Hair Cycle Protein Binding Cytosol Mesenchymal Cell Development
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