TMED8 and CYB561D1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMED8	CYB561D1
Description		transmembrane p24 trafficking protein family member 8	cytochrome b561 family member D1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Membrane
	Molecular Function	Protein Binding	Protein Binding Metal Ion Binding Transmembrane Ascorbate Ferrireductase Activity Transmembrane Monodehydroascorbate Reductase Activity
	Biological Process		Transmembrane Transport
Pathways
Drugs
Diseases
GWAS			Chronic kidney disease ( 20383146) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cognitive function ( 28093568) General cognitive ability ( 29844566) Major depressive disorder ( 20125088) Obesity-related traits ( 23251661) Smoking behaviour (cigarette pack-years) ( 30679032)
Interacting Genes		32 interacting genes: ADTRP AMIGO2 APOL2 ARL6IP1 C10orf67 CIAO2A CMTM5 CMTM6 CYB561D1 DEFB129 DERL1 DGAT2L6 EI24 H4C7 LAPTM4A MDK MMGT1 MRPL41 MRPS18B MTIF3 NDUFA12 REEP6 SERP2 STX8 SUSD3 TMEM115 TMEM121 TMEM218 TMEM254 TRAM1L1 UNC50 ZDHHC16	4 interacting genes: AQP6 CFTR GAD2 TMED8
Entrez ID		283578	284613
HPRD ID		18201	09902
Ensembl ID		ENSG00000100580	ENSG00000174151
Uniprot IDs		Q6PL24	Q6ZQS1 Q8N8Q1
PDB IDs
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane	Fluid Transport Water Transport PH-gated Chloride Channel Activity Nitrate Transmembrane Transporter Activity Nitrate Transmembrane Transport Chloride Transmembrane Transport Monoatomic Anion Transmembrane Transport Inorganic Anion Transmembrane Transport Inorganic Anion Transport Odontogenesis Monoatomic Anion Transport Chloride Transport Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Gamma-aminobutyrate Shunt Glutamate Decarboxylase Activity Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Enamel Mineralization Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Transepithelial Water Transport Monoatomic Anion Channel Activity Renal Water Transport Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Gamma-aminobutyric Acid Biosynthetic Process L-glutamate Catabolic Process Gamma-aminobutyric Acid Metabolic Process Succinate Metabolic Process Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Ammonium Channel Activity Amelogenesis Carbon-carbon Lyase Activity Ammonium Transmembrane Transport ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Water Channel Activity Golgi-associated Vesicle Membrane Carbon Dioxide Transport Cellular Response To Forskolin Small Molecule Biosynthetic Process Response To Forskolin
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