TUBB8 and UBASH3A

Number of citations of the paper that reports this interaction (PubMedID 31659016)
58

Data Source:
BioGRID (pull down)

		TUBB8	UBASH3A
Description		tubulin beta 8 class VIII	ubiquitin associated and SH3 domain containing A
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Spindle Cytoskeleton Microtubule Microtubule Cytoskeleton Intercellular Bridge Extracellular Exosome Mitotic Spindle Meiotic Spindle	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck Extracellular Exosome
	Molecular Function	Nucleotide Binding GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Metal Ion Binding	Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Oocyte Maturation Microtubule-based Process Spindle Assembly Involved In Female Meiosis	Regulation Of Cytokine Production Negative Regulation Of T Cell Receptor Signaling Pathway
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Recruitment of NuMA to mitotic centrosomes Recycling pathway of L1 Recycling pathway of L1 Cargo trafficking to the periciliary membrane RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling
Drugs
Diseases
GWAS			Addison's disease ( 33574239) Asthma ( 32296059) Autoimmune traits (pleiotropy) ( 30572963) Celiac disease ( 22057235 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Diverticular disease ( 30177863) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Lymphocyte count ( 32888494) Medication use (thyroid preparations) ( 31015401) Primary sclerosing cholangitis ( 27992413) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Type 1 diabetes ( 18840781 30572963 25751624 21829393 19430480) Vitiligo ( 27723757 20410501)
Interacting Genes		1 interacting genes: UBASH3A	105 interacting genes: ARRDC1 ARRDC3 ATF6 BCAR3 CBLB CBS CCDC33 CD3E COPS9 CUEDC1 CXXC5 DAZAP2 DDIT4L DISC1 DLG1 DLGAP4 DNM2 DTX3 EHMT2 FADS6 FAM83A FGFR1OP2 GFAP GOLGA6L9 HSP90AA1 HSP90B1 HSPD1 IKBKG ISY1-RAB43 KCNE1 KCTD1 KIAA0408 KPRP KRT14 KRT31 KRT32 KRT35 KRT39 KRT40 LCN2 LNX1 LZTS1 LZTS2 MAP3K7 MKRN1 MTIF2 N4BP3 NEUROD2 NSMF PDE7A PFDN2 PLEKHB2 PMEPA1 PNMA5 PRDM6 PRKN PSMC1 PSMC4 REL RNF216 RNF41 SF3B4 SH3RF1 SHISA6 SLA2 SLC4A3 SNRNP48 SOS1 SOS2 SPMIP6 SPRY1 SPRY2 SPRYD7 STX11 TAOK1 TAX1BP1 TEKT1 TEKT4 TIMM44 TMCO2 TMEM239 TP53BP2 TP63 TRIM27 TRIM37 TRIM5 TRIM50 TRIM8 TUBB8 UBB UBC UBE2L3 VCP VPS37B VPS72 WAS WASL WBP11 YPEL3 ZBTB42 ZC2HC1C ZIC3 ZNF219 ZNF474 ZRANB1
Entrez ID		347688	53347
HPRD ID		18244	06904
Ensembl ID		ENSG00000261456	ENSG00000160185
Uniprot IDs		Q3ZCM7	P57075
PDB IDs			2CRN 5WDI
Enriched GO Terms of Interacting Partners?		Positive Regulation Of 3'-UTR-mediated MRNA Stabilization	Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Binding Inclusion Body Assembly Post-translational Protein Modification Ubiquitin Protein Ligase Activity Intermediate Filament Organization Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Structural Constituent Of Skin Epidermis Supramolecular Fiber Organization Identical Protein Binding Aggresome Assembly Proteolysis Involved In Protein Catabolic Process Morphogenesis Of An Epithelium Positive Regulation Of Catabolic Process Sperm Plasma Membrane WW Domain Binding Protein Binding Regulation Of Post-translational Protein Modification Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Keratin Filament Canonical NF-kappaB Signal Transduction Negative Regulation Of Membrane Tubulation Cytosol Cytoskeleton Organization Tissue Morphogenesis Positive Regulation Of Protein Catabolic Process Organelle Organization Modification-dependent Protein Catabolic Process Intermediate Filament Protein Polyubiquitination Macromolecule Catabolic Process Regulation Of Cell Communication Cytoplasm Regulation Of Signaling Regulation Of Intracellular Signal Transduction SH3 Domain Binding P53 Binding Protein Localization To Mitochondrion Linear Polyubiquitin Binding Regulation Of Protein Catabolic Process Protein Polymerization Regulation Of Autophagy Regulation Of Signal Transduction Suppression Of Viral Release By Host Positive Regulation Of Protein Metabolic Process Regulation Of Type I Interferon Production Positive Regulation Of Post-translational Protein Modification Ubiquitin-protein Transferase Activity
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